DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fign and Fignl1

DIOPT Version :9

Sequence 1:	NP_001259995.1	Gene:	Fign / 33544	FlyBaseID:	FBgn0031519	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	XP_011242039.1	Gene:	Fignl1 / 60530	MGIID:	1890648	Length:	692	Species:	Mus musculus

Alignment Length:	549	Identity:	211/549 - (38%)
Similarity:	310/549 - (56%)	Gaps:	49/549 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EQSSWRSKLLLICQQTRSSSESIHFAALKDHHA-RLQA-------CESMEKAM--KERCQKKITM 58
            |.:::....|.:|    ..||.....:...|.. :.||       |...:.|.  ||....|..:
Mouse   158 EPTAFEVPQLSVC----GGSEDADILSSSGHDTDKTQAIPGSSLRCSPFQSARLPKETNTTKTCL 218

  Fly    59 SRRTKRGITHAGYLFEMPHNSVFEPECRGFYESCQQTEMASSDLQAPALEVSSTYPVQQAVKSRP 123
            :..|..|.:........|.....|.:.:.|.::.....|..|:|..    |.|.....|..|:..
Mouse   219 TSSTSLGESATAAFHMTPLFGNTEKDTQSFPKTSTGLNMFLSNLSC----VPSGCENPQERKAFN 279

  Fly   124 EGQFPESRNNST-----KKIDAQQYSSESSSQSGFGFRTAREQLIMDELKKKNR-QATSEVDAVP 182
            :....:..:|.|     .|.:.:....::|..:   |:||:|||.:|:.||.:: |.||:..
Mouse   280 DSDIIDILSNPTLNKAPSKTEDRGRREDNSLPT---FKTAKEQLWVDQKKKGHQSQHTSKSS--- 338

  Fly   183 TGMMNFRKKTLGGKRT--VSSNFVSPVAQNDNST--------SSRSSSIPPA------LAHLDSK 231
            .|:|   ||:||..|:  :...||.||:...:.:        |||:.|..||      |.:::.:
Mouse   339 NGVM---KKSLGAGRSRGIFGKFVPPVSNKQDGSEQHAKKHKSSRAGSAEPAHLTDDCLKNVEPR 400

  Fly   232 MVDHILGESMHDFKPVAWEDIAGLESAKSTFLEAIIMPLRRPDLFTGVRCPPRGVLLFGPPGTGK 296
            ||:.|:.|.|....||.|:||||:|.||:|..|.::.|:.|||:|||:|.||:|:||||||||||
Mouse   401 MVELIMNEIMDHGPPVHWDDIAGVEFAKATIKEIVVWPMMRPDIFTGLRGPPKGILLFGPPGTGK 465

  Fly   297 TLIAKSIASQAKAKFFSINPSSLTSKWVGDAEKLVKTLFAVAAAHQPAIIFIDEVDSLLSKRSAN 361
            |||.|.||||:.|.||||:.|||||||||:.||:|:.|||||...|||:|||||:|||||:|...
Mouse   466 TLIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEIDSLLSQRGDG 530

  Fly   362 ENESTLRLKNEFLIHLDGAASNEEIRVLVIGATNRPQELDEAVRRRFVRRLYVPLPTREARQKII 426
            |:||:.|:|.|||:.||||.::.|.|:||:||||||||:|||.|||.|:|||:|||...||::|:
Mouse   531 EHESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEAARRRLVKRLYIPLPEASARKQIV 595

  Fly   427 EKLIHQVKHNLDVRQVIELAELTDGYSGADVDTLCRYASMAPLRSLTPDQMEVIETHQLPAVTMD 491
            ..|:.:.:..|...:...:.:.:||:||||:..|||.||:.|:|||....:..|...|:..:...
Mouse   596 GNLMSKEQCCLSDEETDLVVQQSDGFSGADMTQLCREASLGPIRSLHAADIATISPDQVRPIAYI 660

  Fly   492 DFKQALRVISKSVSSEDCKQFEAWNEIYG 520
            ||:.|.:.:..:||.:|.:.:|.|||.:|
Mouse   661 DFENAFKTVRPTVSPKDLELYENWNETFG 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fign	NP_001259995.1	AAA	282..418	CDD:214640	93/135 (69%)
		AAA	286..416	CDD:278434	88/129 (68%)
		Vps4_C	<480..520	CDD:286426	12/39 (31%)
Fignl1	XP_011242039.1	RecA-like_Figl-1	398..583	CDD:410933	115/184 (63%)
		AAA_lid_3	608..>639	CDD:407720	12/30 (40%)
		Vps4_C	<649..689	CDD:401324	12/39 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848173
Domainoid	1	1.000	186	1.000	Domainoid score	I3354
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11063
Inparanoid	1	1.050	336	1.000	Inparanoid score	I2379
Isobase	1	0.950	-	0	Normalized mean entropy	S1759
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1176820at2759
OrthoFinder	1	1.000	-	-		FOG0001088
OrthoInspector	1	1.000	-	-		otm43216
orthoMCL	1	0.900	-	-		OOG6_100722
Panther	1	1.100	-	-	LDO	PTHR23074
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2527
SonicParanoid	1	1.000	-	-		X1766
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740