DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fign and Fign

DIOPT Version :9

Sequence 1:	NP_001259995.1	Gene:	Fign / 33544	FlyBaseID:	FBgn0031519	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_068362.1	Gene:	Fign / 60344	MGIID:	1890647	Length:	759	Species:	Mus musculus

Alignment Length:	483	Identity:	151/483 - (31%)
Similarity:	260/483 - (53%)	Gaps:	44/483 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 THAGYLFE-----------MPHNSVFEPECRGFYESCQQTEMASSDLQAPALEVSSTYPVQQAVK 120
            |..||.::           :.:||....:.:.|| ...|.:|.||       ..:.:|..|::.:
Mouse   289 TVPGYTYQGHGLTPIAPSALTNNSASSLKRKAFY-MAGQGDMDSS-------YGNYSYGQQRSTQ 345

  Fly   121 SRPEGQFPESRNNSTKKIDAQQYSSESSSQSGFGFRTAREQLIMDELKKKNRQATSEVDAVPTGM 185
            | |..:.|::..:::.:.:....::|:||   ..|:..: ||:..|.::|....:|.....|:
Mouse   346 S-PMYRMPDNSISNSNRGNGFDRNAETSS---LAFKPTK-QLMPSEQQRKFSSQSSRALTPPS-- 403

  Fly   186 MNFRKKTLGGKRTVS-SNFVSPVAQND-----------------NSTSSRSSSIPPALAHLDSKM 232
            .:..|.:||.:.:.| ..:.|||....                 .:.:|.:.|:...|.:.|:.:
Mouse   404 YSTAKNSLGSRSSESFGKYTSPVMSEHGDDHRQLLAHPIQGPGLRAATSSNHSVDEQLKNTDTHL 468

  Fly   233 VDHILGESMHDFKPVAWEDIAGLESAKSTFLEAIIMPLRRPDLFTGVRCPPRGVLLFGPPGTGKT 297
            :|.:..|.:....||.|.|||||:..|:...|.::.|:.|.|.|:|:...||.:|||||.|||||
Mouse   469 IDLVTNEIITQGPPVDWSDIAGLDLVKAVIKEEVLWPVLRSDAFSGLTALPRSILLFGPRGTGKT 533

  Fly   298 LIAKSIASQAKAKFFSINPSSLTSKWVGDAEKLVKTLFAVAAAHQPAIIFIDEVDSLLSKRSANE 362
            |:.:.||||..|.||.|..|.|.:||:|:|||::...|.||...||::||:.::|.|||.:.:.|
Mouse   534 LLGRCIASQLGATFFKIAGSGLVAKWIGEAEKIIHASFLVARCRQPSVIFVSDIDMLLSSQVSEE 598

  Fly   363 NESTLRLKNEFLIHLDGAASNEEIRVLVIGATNRPQELDEAVRRRFVRRLYVPLPTREARQKIIE 427
            :....|::.|||:.||...::.|.:::||.||::|:|:||::||.|::||.:|||...||.:||.
Mouse   599 HSPVSRMRTEFLMQLDTVLTSAEDQIVVICATSKPEEIDESLRRYFMKRLLIPLPDSTARHQIIV 663

  Fly   428 KLIHQVKHNLDVRQVIELAELTDGYSGADVDTLCRYASMAPLRSLTPDQMEVIETHQLPAVTMDD 492
            :|:.|..:.|:.::...|.:.|:|:||.||..||:.|::.||.::....:..|...||..||..|
Mouse   664 QLLTQHNYCLNDKEFALLVQRTEGFSGLDVAHLCQEAAVGPLHAMPATDLSAIMPSQLRPVTYQD 728

  Fly   493 FKQALRVISKSVSSEDCKQFEAWNEIYG 520
            |:.|...|..|:|.::...:..||:::|
Mouse   729 FENAFCKIQPSISQKELDMYVEWNKMFG 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fign	NP_001259995.1	AAA	282..418	CDD:214640	63/135 (47%)
		AAA	286..416	CDD:278434	59/129 (46%)
		Vps4_C	<480..520	CDD:286426	13/39 (33%)
Fign	NP_068362.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..111
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	200..237
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	258..293		1/3 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	337..429		19/92 (21%)
		26Sp45	389..736	CDD:130309	125/364 (34%)
		AAA	522..652	CDD:278434	55/129 (43%)
		Vps4_C	<723..756	CDD:286426	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848178
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	336	1.000	Inparanoid score	I2379
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43216
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23074
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1766
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.890