DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fign and Spata5

DIOPT Version :9

Sequence 1:	NP_001259995.1	Gene:	Fign / 33544	FlyBaseID:	FBgn0031519	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_001156983.1	Gene:	Spata5 / 57815	MGIID:	1927170	Length:	893	Species:	Mus musculus

Alignment Length:	467	Identity:	142/467 - (30%)
Similarity:	222/467 - (47%)	Gaps:	65/467 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 GFYESCQQTE---MASSDLQAPALEVSSTYPVQQAVKSRPEGQFPESRNNSTKK----------- 137
            |..:|...|:   |||......:.:|..::.:.|.....|  |.|.|::...|.
Mouse   203 GKLQSASGTDAQGMASEHSSMESSDVDLSFQLSQLDLKEP--QSPSSQSTPCKPTNDRTVNKAGE 265

  Fly   138 --IDAQQYSSESSSQSGFGFRTARE-QLIMDELKKKNRQATSEVDAVPTGMMNFRKKTLGGK-RT 198
              :|..|...:.   ||.|...:.. :...|..|:.|.|..||...:       :..:.|.| .|
Mouse   266 VLLDVTQSPRDG---SGLGLEESTGLKCSFDSSKEGNTQPVSEEKLL-------KPASAGTKSNT 320

  Fly   199 VSSNFVSPVAQ---NDNSTSSRSSSIPPALAHLDSKMVDHILGESMHDFKPVAWEDIAGLESAKS 260
            .:..|:|...:   ....|:|:..         ||:            || |.::.|.||.|...
Mouse   321 DTFYFISSTTRINLRKICTNSKEQ---------DSQ------------FK-VTYDMIGGLNSQLK 363

  Fly   261 TFLEAIIMPLRRPDLFTGVRCP-PRGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWV 324
            ...|.|.:||::|:||.....| |||:||:||||||||:||:::|::..|....||...:.||:.
Mouse   364 AIREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFY 428

  Fly   325 GDAEKLVKTLFAVAAAHQPAIIFIDEVDSLLSKRSANENESTLRLKNEFLIHLDGAAS-NEEIRV 388
            |:.|..::.:||.|....|:||||||:|:|..||...::|...|:....|..:||..| ..|.||
Mouse   429 GETEARLRQIFAEATLRHPSIIFIDELDALCPKREGAQSEVEKRVVASLLTLMDGIGSEGSEGRV 493

  Fly   389 LVIGATNRPQELDEAVRR--RFVRRLYVPLPTREARQKIIEKLIHQVKHNLDVRQVIELAELTDG 451
            ||:|||||||.||.|:||  ||.:.:.:.:|..:.|..|::||:.:|.|.|...:::.||....|
Mouse   494 LVLGATNRPQALDAALRRPGRFDKEIEIGIPNAQDRLDILQKLLRRVPHLLTKAELLRLANNAHG 558

  Fly   452 YSGADVDTLCRYASMAPLRSLTPDQMEVIETH--QLPAVTMDDFKQALRVISKSVSSE---DCKQ 511
            |.|||:..||..|.:..||.:...|..:.::.  .:..:|::||.|.:..|..|...|   |...
Mouse   559 YVGADLKALCNEAGLHALRRVLRKQPNLPDSKVAGMVKITLNDFLQGMNDIRPSAMREVAIDVPN 623

  Fly   512 FEAWNEIYGVRH 523
            . :|::|.|:.:
Mouse   624 V-SWSDIGGLEN 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fign	NP_001259995.1	AAA	282..418	CDD:214640	63/139 (45%)
		AAA	286..416	CDD:278434	59/132 (45%)
		Vps4_C	<480..520	CDD:286426	10/44 (23%)
Spata5	NP_001156983.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38
		CDC48_N	64..132	CDD:304500
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	202..227		6/23 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	239..315		16/87 (18%)
		SpoVK	370..882	CDD:223540	100/266 (38%)
		AAA	390..522	CDD:278434	59/131 (45%)
		AAA	664..796	CDD:278434
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810