DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fign and fignl1

DIOPT Version :9

Sequence 1:	NP_001259995.1	Gene:	Fign / 33544	FlyBaseID:	FBgn0031519	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_001122223.1	Gene:	fignl1 / 569539	ZFINID:	ZDB-GENE-030131-1862	Length:	661	Species:	Danio rerio

Alignment Length:	586	Identity:	213/586 - (36%)
Similarity:	318/586 - (54%)	Gaps:	99/586 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 SIHFAA-LKDHHARLQACESMEKAMKERCQKKITMSRRT-----------------------KRG 65
            ::|.|. .|:|..:.::..::|......|.:|:..:|..                       ::|
Zfish    82 ALHLARNQKNHSDKWESSLTLENVFNLSCVQKMIQARSDGCALPVDPADVNISVGGEVSGGGEKG 146

  Fly    66 ITHAGYLFEMPHNSVFEPECRGFYESCQQTEMASSDLQ----APALEVSSTYPVQQAVKSRPEG- 125
            .:.:|    .|.....||...|........|||..|:.    :..|||:.  |.....::.|:|
Zfish   147 SSLSG----PPSGLKQEPLAHGHSVPLPTAEMARGDINPISGSGGLEVAP--PRFSLAQNTPKGL 205

  Fly   126 -----------------QFPE------SRNN---------STKKIDAQQY--SSESSSQSGF--- 153
                             ..|:      ||:|         ||.....:.:  |...||:|.|
Zfish   206 TGSTIFGHNNFGSTGNAVVPQSNVACTSRSNVHNQPVFFSSTNPSKRKNFYGSGTESSRSSFPSQ 270

  Fly   154 ------------------GFRTAREQLIMDELKKKNRQATSEVDAVPTGMMNFRKKTLGGKRT-- 198
                              .||:||||.|:|:.||.:.|...   ..|..:....||.||..|:
Zfish   271 GEQELRGRGLRGEEGISTNFRSAREQFIVDQQKKHSHQGQR---GSPGNVFTITKKCLGANRSRG 332

  Fly   199 VSSNFVSPVAQND----NSTSSRSSSIPPALAHLDSKMVDHILGESMHDFKPVAWEDIAGLESAK 259
            .||.|:||:.:.:    ::|......:...|.:.:.|:::.|:.|.|....||||:||||||.||
Zfish   333 ASSKFISPMPRQEEDLKDNTPKDMQPVDERLKNFEPKIIELIMSEIMDHGPPVAWDDIAGLEFAK 397

  Fly   260 STFLEAIIMPLRRPDLFTGVRCPPRGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWV 324
            :|..|.::.|:.|||:|||:|.||:|:|||||||||||||.|.||.|:.|.||||:.||||||||
Zfish   398 ATIKEIVVWPMLRPDIFTGLRGPPKGILLFGPPGTGKTLIGKCIACQSGATFFSISASSLTSKWV 462

  Fly   325 GDAEKLVKTLFAVAAAHQPAIIFIDEVDSLLSKRSANENESTLRLKNEFLIHLDGAASNEEIRVL 389
            |:.||:|:.|||:|..||||:|||||:|||||:|:..|::|:.|:|.|||:.|||||::.|.|:|
Zfish   463 GEGEKMVRALFAIARCHQPAVIFIDEIDSLLSQRTDGEHDSSRRIKTEFLVQLDGAATSAEDRIL 527

  Fly   390 VIGATNRPQELDEAVRRRFVRRLYVPLPTREARQKIIEKLIHQVKHNLDVRQVIELAELTDGYSG 454
            |:||||||||:|||.|||..:|||:|||..|||::|:..|:...|..|.|.::.::.:.|:|:||
Zfish   528 VVGATNRPQEIDEAARRRLAKRLYIPLPEAEARRQIVTNLMSHEKSQLGVDEMEKVVQGTEGFSG 592

  Fly   455 ADVDTLCRYASMAPLRSLTPDQMEVIETHQLPAVTMDDFKQALRVISKSVSSEDCKQFEAWNEIY 519
            ||:..|||.|::.|:||::...:..|...|:..:...||::||:.:..||||:|.:.:|.||:.:
Zfish   593 ADMTQLCREAALGPIRSISLSDIATIMAEQVRPILYSDFQEALKTVRPSVSSKDLELYEEWNKTF 657

  Fly   520 G 520
            |
Zfish   658 G 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fign	NP_001259995.1	AAA	282..418	CDD:214640	91/135 (67%)
		AAA	286..416	CDD:278434	86/129 (67%)
		Vps4_C	<480..520	CDD:286426	14/39 (36%)
fignl1	NP_001122223.1	AAA	420..556	CDD:214640	91/135 (67%)
		AAA	424..554	CDD:278434	86/129 (67%)
		Vps4_C	<610..658	CDD:286426	14/47 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593575
Domainoid	1	1.000	185	1.000	Domainoid score	I3323
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11063
Inparanoid	1	1.050	357	1.000	Inparanoid score	I2192
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1176820at2759
OrthoFinder	1	1.000	-	-		FOG0001088
OrthoInspector	1	1.000	-	-		oto39526
orthoMCL	1	0.900	-	-		OOG6_100722
Panther	1	1.100	-	-	LDO	PTHR23074
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2527
SonicParanoid	1	1.000	-	-		X1766
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.790