DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fign and spast

DIOPT Version :9

Sequence 1:	NP_001259995.1	Gene:	Fign / 33544	FlyBaseID:	FBgn0031519	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	XP_012818464.1	Gene:	spast / 549207	XenbaseID:	XB-GENE-947839	Length:	603	Species:	Xenopus tropicalis

Alignment Length:	532	Identity:	179/532 - (33%)
Similarity:	278/532 - (52%)	Gaps:	71/532 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 ERCQKKITMSRRTKRGITHAGYLFEMPHNSVFEPE-CRGFYESCQQTEMASSDLQAPALEVSSTY 113
            ||..:::...:.:....|.|....:.|.    ||| .|.:::  |..:..|..|:....|....
Frog    78 ERLSRRVMADKGSTAARTAAAPAQDRPQ----EPEVVRSYHQ--QAFQYISMALRIDEEEKDQK- 135

  Fly   114 PVQQAVKSRPEG-----------------QFPESRNNSTK------------------KIDAQQY 143
              :||::...:|                 |:..:|....|                  |.|.|..
Frog   136 --EQAIQWYKKGIEELEKGIAVTITGKGEQYDRARRLQAKMSTNLLMAKDRLQLLAKLKADIQGQ 198

  Fly   144 SSESSSQSGFGFRTAREQLIMDEL----KKK-----NRQATSEVDAVP-TGMMNFRKKTLGGKRT 198
            .|:....|.......|..|:..|.    |||     :..:.|.|.|.| :|.:..|.....|..:
Frog   199 HSQMEVCSDNTNLPCRNGLLKPEKGAVPKKKDPPSISSNSYSRVKAAPKSGSLGNRIPNCTGVSS 263

  Fly   199 VSSNFVSPVAQND------NSTSSRSSSIPPA---------LAHLDSKMVDHILGESMHDFKPVA 248
             |:....|.|.::      |:|.:...:.|..         |.::||.:.:.||.|.:.....|.
Frog   264 -SARQAGPNAPSNRGAAGKNNTRTNKPTTPTTAVRKKDMKNLRNVDSNLANLILNEIVDSGPTVK 327

  Fly   249 WEDIAGLESAKSTFLEAIIMPLRRPDLFTGVRCPPRGVLLFGPPGTGKTLIAKSIASQAKAKFFS 313
            :.||||.:.||....|.:|:|..||:||||:|.|.||:|||||||.|||::||::|:::.|.||:
Frog   328 FADIAGQDLAKQALQEIVILPSIRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFN 392

  Fly   314 INPSSLTSKWVGDAEKLVKTLFAVAAAHQPAIIFIDEVDSLLSKRSANENESTLRLKNEFLIHLD 378
            |:.:|||||:||:.||||:.||:||...||:|||||||||||.:|...|::::.|||.||||..|
Frog   393 ISAASLTSKYVGEGEKLVRALFSVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFD 457

  Fly   379 GAASNEEIRVLVIGATNRPQELDEAVRRRFVRRLYVPLPTREARQKIIEKLIHQVKHNLDVRQVI 443
            |..|..:.||||:||||||||||:||.|||.:|:||.||..|.|..:::.|:.:..:.|:.:::.
Frog   458 GVQSGGDDRVLVMGATNRPQELDDAVLRRFTKRVYVSLPNEETRLLLLKNLLSKQGNPLNEKELT 522

  Fly   444 ELAELTDGYSGADVDTLCRYASMAPLRSLTPDQMEVIETHQLPAVTMDDFKQALRVISKSVSSED 508
            :|:.||:||||:|:..|.:.|::.|:|.|.|:|::.:...::..:...||..:|:.|..|||...
Frog   523 QLSRLTEGYSGSDITALAKDAALGPIRELKPEQVKNMAASEMRNIKYSDFLSSLKKIKCSVSPST 587

  Fly   509 CKQFEAWNEIYG 520
            .:.:..||:.:|
Frog   588 LESYIRWNKEFG 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fign	NP_001259995.1	AAA	282..418	CDD:214640	83/135 (61%)
		AAA	286..416	CDD:278434	79/129 (61%)
		Vps4_C	<480..520	CDD:286426	9/39 (23%)
spast	XP_012818464.1	MIT_spastin	110..188	CDD:239142	11/82 (13%)
spast	XP_012818464.1	SpoVK	<278..584	CDD:223540	134/305 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1176820at2759
OrthoFinder	1	1.000	-	-		FOG0001088
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920