DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fign and PEX6

DIOPT Version :9

Sequence 1:	NP_001259995.1	Gene:	Fign / 33544	FlyBaseID:	FBgn0031519	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_000278.3	Gene:	PEX6 / 5190	HGNCID:	8859	Length:	980	Species:	Homo sapiens

Alignment Length:	278	Identity:	99/278 - (35%)
Similarity:	150/278 - (53%)	Gaps:	19/278 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   247 VAWEDIAGLESAKSTFLEAIIMPLRRPDLFT-GVRCPPRGVLLFGPPGTGKTLIAKSIASQAKAK 310
            |:|.|:.||:..|...||.|.:||..|:|.: |:|  ..|:||.|||||||||:||::|::....
Human   702 VSWHDVGGLQEVKKEILETIQLPLEHPELLSLGLR--RSGLLLHGPPGTGKTLLAKAVATECSLT 764

  Fly   311 FFSINPSSLTSKWVGDAEKLVKTLFAVAAAHQPAIIFIDEVDSLLSKRSANENESTL--RLKNEF 373
            |.|:....|.:.:||.:|:.|:.:||.|.|..|.|||.||:|||...|..:.:...:  |:.::.
Human   765 FLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSGGVMDRVVSQL 829

  Fly   374 LIHLDGAASNEEIRVLVIGATNRPQELDEAVRR--RFVRRLYVPLPTREARQ-KIIEKLIHQVKH 435
            |..|||..|.::  |.||||||||..||.|:.|  ||.:.::|......|.| :::..:..:.|.
Human   830 LAELDGLHSTQD--VFVIGATNRPDLLDPALLRPGRFDKLVFVGANEDRASQLRVLSAITRKFKL 892

  Fly   436 NLDVRQVIELAELTDGYSGADVDTLCRYASMAPLRSLTPDQMEVIETHQLPA-----VTMDDFKQ 495
            ...|..|..|.......:|||:.:||..|..|.|:....|..|.:|    |.     :||:|..|
Human   893 EPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKRRVHDLEEGLE----PGSSALMLTMEDLLQ 953

  Fly   496 ALRVISKSVSSEDCKQFE 513
            |...:..|||.::..:::
Human   954 AAARLQPSVSEQELLRYK 971

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fign	NP_001259995.1	AAA	282..418	CDD:214640	58/139 (42%)
		AAA	286..416	CDD:278434	57/133 (43%)
		Vps4_C	<480..520	CDD:286426	10/39 (26%)
PEX6	NP_000278.3	SpoVK	463..967	CDD:223540	99/272 (36%)
		AAA	466..594	CDD:278434
		AAA	743..871	CDD:278434	54/129 (42%)
		Vps4_C	918..977	CDD:286426	16/58 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810