DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fign and PEX1

DIOPT Version :9

Sequence 1:	NP_001259995.1	Gene:	Fign / 33544	FlyBaseID:	FBgn0031519	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_000457.1	Gene:	PEX1 / 5189	HGNCID:	8850	Length:	1283	Species:	Homo sapiens

Alignment Length:	345	Identity:	93/345 - (26%)
Similarity:	163/345 - (47%)	Gaps:	49/345 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 NSTKKIDAQQYSSESSSQSGFGFRTAREQLIMDELKKKNRQATSEVDAVPTGMMNFRKKTLGGKR 197
            |....:|.|..:.|:.......|....::.|...|   :||:.|..:.:....::|:|...|
Human   762 NKFTDLDLQHVAKETGGFVARDFTVLVDRAIHSRL---SRQSISTREKLVLTTLDFQKALRG--- 820

  Fly   198 TVSSNFVSPVAQNDNSTSSRSSSIPPALAHLDSKMVDHILGESMHDFKPVAWEDIAGLESAKSTF 262
                                  .:|.:|..:           ::|..:.:.|:.|.||...:...
Human   821 ----------------------FLPASLRSV-----------NLHKPRDLGWDKIGGLHEVRQIL 852

  Fly   263 LEAIIMPLRRPDLFTGVRCPPR-GVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWVGD 326
            ::.|.:|.:.|:||..:....| |:||:|||||||||:|..||.:::..|.|:....|.||::|.
Human   853 MDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVIARESRMNFISVKGPELLSKYIGA 917

  Fly   327 AEKLVKTLFAVAAAHQPAIIFIDEVDSLLSKRSANENESTLRLKNEFLIHLDGAASNEEIRVLVI 391
            :|:.|:.:|..|.|.:|.|:|.||.:|:..:|..:....|.|:.|:.|..|||....:  .|.|:
Human   918 SEQAVRDIFIRAQAAKPCILFFDEFESIAPRRGHDNTGVTDRVVNQLLTQLDGVEGLQ--GVYVL 980

  Fly   392 GATNRPQELDEAVRR--RFVRRLYVPLPTREARQKIIEKLIHQ--VKHNLDVRQVIELAELTDGY 452
            .||:||..:|.|:.|  |..:.:|.|.|.:.:|.:|:..|...  :..::|::.|   |.:||.:
Human   981 AATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLEILNVLSDSLPLADDVDLQHV---ASVTDSF 1042

  Fly   453 SGADVDTLCRYASMAPLRSL 472
            :|||:..|...|.:..|..:
Human  1043 TGADLKALLYNAQLEALHGM 1062

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fign	NP_001259995.1	AAA	282..418	CDD:214640	53/138 (38%)
		AAA	286..416	CDD:278434	50/131 (38%)
		Vps4_C	<480..520	CDD:286426
PEX1	NP_000457.1	PEX-2N	19..98	CDD:286362
		PEX-1N	104..179	CDD:286361
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	346..367
		SpoVK	595..1063	CDD:223540	93/345 (27%)
		AAA	595..731	CDD:278434
		AAA	877..1006	CDD:278434	50/130 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1260..1283
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900