DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Fign and Spast

DIOPT Version :9

Sequence 1:NP_001259995.1 Gene:Fign / 33544 FlyBaseID:FBgn0031519 Length:523 Species:Drosophila melanogaster
Sequence 2:NP_001156342.1 Gene:Spast / 50850 MGIID:1858896 Length:614 Species:Mus musculus


Alignment Length:473 Identity:169/473 - (35%)
Similarity:262/473 - (55%) Gaps:72/473 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    89 YESCQQTE--------MASSDLQAPALEVSSTYPVQQAVKSRPEGQFPESRNNSTKKIDAQQYSS 145
            ||..::.:        ||...||.    :....||.|..||:.: .:.||.|.:.:       :.
Mouse   169 YERARRLQAKMMTNLVMAKDRLQL----LEKLQPVLQFSKSQTD-VYNESTNLTCR-------NG 221

  Fly   146 ESSSQSGFGFRTAREQLIMDELKKKNRQATSEVDAVPTGMMNFRKKTL---------GGKRTVSS 201
            ...|:||             .:.|:....|...:::|      |.||:         |..|..|.
Mouse   222 HLQSESG-------------AVPKRKDPLTHASNSLP------RSKTVLKSGSAGLSGHHRAPSC 267

  Fly   202 NFVS----------PVAQNDNSTSSRSSSIPPA--------------LAHLDSKMVDHILGESMH 242
            :.:|          |.|.....|...:.:..|:              ..::||.:.:.|:.|.:.
Mouse   268 SGLSMVSGARPGPGPAATTHKGTPKPNRTNKPSTPTTAVRKKKDLKNFRNVDSNLANLIMNEIVD 332

  Fly   243 DFKPVAWEDIAGLESAKSTFLEAIIMPLRRPDLFTGVRCPPRGVLLFGPPGTGKTLIAKSIASQA 307
            :...|.::||||.|.||....|.:|:|..||:||||:|.|.||:|||||||.|||::||::|:::
Mouse   333 NGTAVKFDDIAGQELAKQALQEIVILPSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAES 397

  Fly   308 KAKFFSINPSSLTSKWVGDAEKLVKTLFAVAAAHQPAIIFIDEVDSLLSKRSANENESTLRLKNE 372
            .|.||:|:.:|||||:||:.||||:.|||||...||:|||||||||||.:|...|::::.|||.|
Mouse   398 NATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTE 462

  Fly   373 FLIHLDGAASNEEIRVLVIGATNRPQELDEAVRRRFVRRLYVPLPTREARQKIIEKLIHQVKHNL 437
            |||..||..|..:.||||:|||||||||||||.|||::|:||.||..|.|..:::.|:.:....|
Mouse   463 FLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPL 527

  Fly   438 DVRQVIELAELTDGYSGADVDTLCRYASMAPLRSLTPDQMEVIETHQLPAVTMDDFKQALRVISK 502
            ..:::.:||.:||||||:|:..|.:.|::.|:|.|.|:|::.:...::..:.:.||.::|:.|.:
Mouse   528 TQKELAQLARMTDGYSGSDLTALAKDAALGPIRELKPEQVKNMSASEMRNIRLSDFTESLKKIKR 592

  Fly   503 SVSSEDCKQFEAWNEIYG 520
            |||.:..:.:..||:.:|
Mouse   593 SVSPQTLEAYIRWNKDFG 610

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FignNP_001259995.1 AAA 282..418 CDD:214640 85/135 (63%)
AAA 286..416 CDD:278434 81/129 (63%)
Vps4_C <480..520 CDD:286426 9/39 (23%)
SpastNP_001156342.1 Required for interaction with RTN1. /evidence=ECO:0000250|UniProtKB:Q9UBP0 1..298 30/159 (19%)
Required for midbody localization. /evidence=ECO:0000250|UniProtKB:Q9UBP0 1..192 5/22 (23%)
Required for interaction with ATL1. /evidence=ECO:0000250|UniProtKB:Q9UBP0 1..78
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..48
Required for nuclear localization. /evidence=ECO:0000250|UniProtKB:Q9UBP0 1..48
Nuclear localization signal. /evidence=ECO:0000255|HAMAP-Rule:MF_03021 4..11
Required for interaction with SSNA1 and microtubules. /evidence=ECO:0000250|UniProtKB:Q9UBP0 48..85
Nuclear export signal. /evidence=ECO:0000255|HAMAP-Rule:MF_03021 57..65
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 91..112
Sufficient for interaction with CHMP1B. /evidence=ECO:0000250|UniProtKB:Q9UBP0 110..194 6/28 (21%)
Required for interaction with microtubules. /evidence=ECO:0000250|UniProtKB:Q9UBP0 112..198 6/32 (19%)
MIT_spastin 114..193 CDD:239142 6/27 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 220..306 17/104 (16%)
Sufficient for microtubule severing. /evidence=ECO:0000250|UniProtKB:Q9UBP0 226..614 154/404 (38%)
Required for interaction with microtubules and microtubule severing. /evidence=ECO:0000250|UniProtKB:Q9UBP0 268..326 7/57 (12%)
Nuclear localization signal. /evidence=ECO:0000255|HAMAP-Rule:MF_03021 307..310 0/2 (0%)
Required for interaction with microtubules. /evidence=ECO:0000250|UniProtKB:Q9UBP0 308..310 0/1 (0%)
P-loop_NTPase 339..>395 CDD:304359 32/55 (58%)
AAA 372..508 CDD:214640 85/135 (63%)
AAA 376..506 CDD:278434 81/129 (63%)
Vps4_C <578..610 CDD:286426 9/31 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0464
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1176820at2759
OrthoFinder 1 1.000 - - FOG0001088
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100722
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.720

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