Protein Alignment Fign and Pex1

DIOPT Version :10

• Sequence 1: NP_608763.2
• Gene: Fign / 33544
• FlyBaseID: FBgn0031519
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_001102690.1
• Gene: Pex1 / 500006
• RGDID: 1559939
• Length: 1283
• Species: Rattus norvegicus
• Alignment Length: 547
• Identity: 128/547 - (23%)
• Similarity: 225/547 - (41%)
• Gaps: 141/547 - (25%)

  Fly     9 RSKLLLICQQTRSSSESIHFAALKDHHARLQA------CESMEKAMKERCQKKITMSRRTKRGIT 67
            |:..|||.....|...::..|..|:.|..|.|      |:::.....|..||.:.::
  Rat   591 RNGALLITGGKGSGKSTLAKAICKEAHDALDAHVEMVDCKALRGKRLESIQKALEVA-------- 647

  Fly    68 HAGYLFEMPHNSVFEPECRGFYESC--QQTEMASSDL-------QAPALEVSSTYPVQQAVKSRP 123
                                |.|:.  |.:.:...||       ..|..|.|     .:||:|:
  Rat   648 --------------------FSEAAWRQPSVILLDDLDLIAGLPSTPEHEHS-----PEAVQSQ- 686

  Fly   124 EGQFPESRNNSTKKIDAQ------------QYSSESSSQSGFGFRTAREQLIMDELKKKNRQATS 176
              :...:.||..|:..:.            |:|...|..|..|..|.:   .:..::..:::...
  Rat   687 --RLAHALNNMIKEFVSMGSLVALIATSQLQHSLHPSLVSAQGVHTFQ---CIQHIQPPDQEQRC 746

  Fly   177 EVDAVPTGMMNFRKKTLG--------------GKRT---VSSNFVSPVAQNDNSTSSRSSS---- 220
            |:      :.:..|..||              .|.|   |:.:|...|.:..:|:.||..:
  Rat   747 EI------LHSVVKNKLGCDISKSPDLDLKCIAKETEAFVARDFTVLVDRAIHSSLSRQQNPTRE 805

  Fly   221 ----------------IPPALAHLDSKMVDHILGESMHDFKPVAWEDIAGLESAKSTFLEAIIMP 269
                            :|.:|.::           ::|..:.:.|:.|.||...:...::.|.:|
  Rat   806 GLTLTTADFQKALRGFLPASLRNV-----------NLHKPRDLGWDKIGGLHEVRQILMDTIQLP 859

  Fly   270 LRRPDLFTGVRCPPR-GVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWVGDAEKLVKT 333
            .:.|:||..:....| |:||:|||||||||:|..:|.::...|.||....|.||::|.:|:.|:.
  Rat   860 AKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVVARESGMNFISIQGPELLSKYIGASEQAVRD 924

  Fly   334 LFAVAAAHQPAIIFIDEVDSLLSKRSANENESTLRLKNEFLIHLDGAASNEEIRVLVIGATNRPQ 398
            :|..|.|.:|.|:|.||.:|:..:|..:....|.|:.|:.|..|||....:  .|.|:.||:||.
  Rat   925 VFIRAQAAKPCILFFDEFESIAPRRGHDNTGVTDRVVNQLLTQLDGVEGLQ--GVYVLAATSRPD 987

  Fly   399 ELDEAVRR--RFVRRLYVPLPTREARQKIIEKLIHQ--VKHNLDVRQVIELAELTDGYSGADVDT 459
            .:|.|:.|  |..:.:|.|.|.:.:|.:|:..|...  :..::|::.|   |.:|:.::|||:..
  Rat   988 LIDPALLRPGRLDKCVYCPPPDQVSRLEILTVLSKSLPLADDVDLQHV---ASVTESFTGADLKA 1049

  Fly   460 LCRYASMAPLRSLTPDQMEVIETHQLP 486
            |...|           |:|.::...||
  Rat  1050 LLYNA-----------QLEALQGRLLP 1065

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fign	NP_608763.2	PH-like	<4..50	CDD:473070	11/46 (24%)
		P-loop containing Nucleoside Triphosphate Hydrolases	229..414	CDD:476819	61/187 (33%)
		AAA_lid_3	444..495	CDD:465537	11/43 (26%)
		Vps4_C	<480..520	CDD:462762	2/7 (29%)
Pex1	NP_001102690.1	PEX-2N	17..98	CDD:462730
		PEX-1N	104..179	CDD:462729
		NACHT	418..>750	CDD:444362	35/203 (17%)
		CDC48	<595..1060	CDD:273521	125/536 (23%)