Protein Alignment Fign and comt

DIOPT Version :10

• Sequence 1: NP_608763.2
• Gene: Fign / 33544
• FlyBaseID: FBgn0031519
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_524877.1
• Gene: comt / 47091
• FlyBaseID: FBgn0000346
• Length: 745
• Species: Drosophila melanogaster
• Alignment Length: 509
• Identity: 125/509 - (24%)
• Similarity: 214/509 - (42%)
• Gaps: 115/509 - (22%)

  Fly    62 TKRGITHAG-YLFEMPHNSVFEPECRGFYESCQQTEMASSDLQAPALEVSSTY------------ 113
            |.|.|.:.| :..|:.:..:.....:.|..:.::|           :||.|.|
  Fly    18 TNRAIVNVGDFPEEIKYADISPAPGQHFIFALEKT-----------VEVPSGYVGFSLVQRKWAM 71

  Fly   114 -PVQQAVKSRP---------------EGQFPESRNNSTKKIDAQQYSSESSSQ-SGFGFRTAREQ 161
             .:.|.::.||               |..|.:.:..|.:..|:.|.:.|...| :|......:..
  Fly    72 VSINQELEVRPYRFDASSDVITCVSFETDFLQKKTVSQEPYDSDQMAKEFIMQFAGMALTVGQSL 136

  Fly   162 LIMDELKKKNRQATSEVDAVPTGMMNFRKKTLG-GKRTVSSN------FVSPVAQNDNSTSSRSS 219
            :...:.||....|...::|:.       .|:|| ||.|...|      ..:.|.|.:.:.:|.
  Fly   137 VFNFKDKKLLGLAVKSLEAID-------PKSLGEGKDTAMRNVRFGRILGNTVVQFEKAENSS-- 192

  Fly   220 SIPPALAHLDSKMVDHILGESM----HDFKPVAWEDIAGLESA-KSTFLEAIIMPLRRPDLFTGV 279
                  .:|..|....::.:|:    .||..:.   |.||:.. .|.|..|....:..|:|...:
  Fly   193 ------LNLQGKSKGKVVRQSIINPDWDFGKMG---IGGLDKEFNSIFRRAFASRVFPPELVEQL 248

  Fly   280 RCP-PRGVLLFGPPGTGKTLIAKSIASQAKAKFFSI-NPSSLTSKWVGDAEKLVKTLFAVAAAHQ 342
            .|. .:|:||:|||||||||:|:.|.:...|:...| |...:..|:||::|..|:.|||.|...:
  Fly   249 GCKHVKGILLYGPPGTGKTLMARQIGTMLNAREPKIVNGPQILDKYVGESEANVRRLFAEAEEEE 313

  Fly   343 PA--------IIFIDEVDSLLSKRSANENESTLR--LKNEFLIHLDGAASNEEIRVLVIGATNRP 397
            ..        ||..||:|::..:|.:....|.:.  :.|:.|..:||.  ::...:||||.|||.
  Fly   314 KRLGPNSGLHIIIFDEIDAICKQRGSVAGNSGVHDTVVNQLLTKIDGV--DQLNNILVIGMTNRR 376

  Fly   398 QELDEAVRR--RFVRRLYVPLPTREARQKIIEKLIH--------QVKHNLDVRQVIELAELTDGY 452
            ..:|||:.|  |...::.:.||..:.|.:|:.  ||        ::..::|.:   |:|.||..:
  Fly   377 DMIDEALLRPGRLEVQMEISLPNEQGRVQILN--IHTKRMREFNKINDDVDNK---EIAALTKNF 436

  Fly   453 SGADVDTLCRYASMAPLRSL---------TPDQMEVIETHQLPAVTMDDFKQAL 497
            |||:::.|.|.|..:.:..|         .|:.||.::      |..|||..:|
  Fly   437 SGAELEGLVRAAQSSAMNRLIKADAKVTVDPEAMEKLK------VNRDDFLHSL 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fign	NP_608763.2	PH-like	<4..50	CDD:473070
		P-loop containing Nucleoside Triphosphate Hydrolases	229..414	CDD:476819	62/203 (31%)
		AAA_lid_3	444..495	CDD:465537	18/59 (31%)
		Vps4_C	<480..520	CDD:462762	5/18 (28%)
comt	NP_524877.1	CDC48_N	5..83	CDD:215012	13/75 (17%)
		CDC48_2	111..>158	CDD:215011	9/53 (17%)
		RecA-like_NSF-SEC18_r1-like	219..395	CDD:410912	58/180 (32%)
		CDC48	<220..>606	CDD:273521	84/278 (30%)
		SpoVK	<526..702	CDD:440232