Protein Alignment Fign and spas

DIOPT Version :10

• Sequence 1: NP_608763.2
• Gene: Fign / 33544
• FlyBaseID: FBgn0031519
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_651206.3
• Gene: spas / 42846
• FlyBaseID: FBgn0039141
• Length: 758
• Species: Drosophila melanogaster
• Alignment Length: 519
• Identity: 180/519 - (34%)
• Similarity: 286/519 - (55%)
• Gaps: 54/519 - (10%)

  Fly     8 W-RSKLLLICQQTRSS--SESIHFAALKDHHARLQACESMEKAMKERCQKKITMSRRTK-RGITH 68
            | |::.|....||..|  .:.:||.||::...::|.. |:::..||..|.|...:|... .|:|:
  Fly   284 WDRAQRLHDKMQTNLSMARDRLHFLALREQDLQMQRL-SLKEKQKEEAQSKPQKTREPMLAGMTN 347

  Fly    69 AGYLFEMPHNSVFEPECRGFYESCQQTEMASSDLQAPALEVSSTYPVQQAVKSRPEGQFPESRNN 133
            ......: .:|.:.|:.         |..|........|.:.|..||..||.::.: ..|.:..:
  Fly   348 EPMKLRV-RSSGYGPKA---------TTSAQPTASGRKLTIGSKRPVNLAVANKSQ-TLPRNLGS 401

  Fly   134 STKKIDAQQYSSESSSQSGFGFRTAREQLIMDELKKKNRQATSEVDAVPTGMMNFRKKTLGGKRT 198
            .|.....|:..::::                               |.|..:   |::...|:.|
  Fly   402 KTSVGAVQRQPAKTA-------------------------------ATPPAV---RRQFSSGRNT 432

  Fly   199 VSSNFVSPVAQNDNSTSSRSSSIP-PALAHLDSKMVDHILGESMHDFKPVAWEDIAGLESAKSTF 262
            ......:|:  |:|..|...:|.| .::..::.|:|..||.|.:.....|.|.||||.:.||...
  Fly   433 PPQRSRTPI--NNNGPSGSGASTPVVSVKGVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQAL 495

  Fly   263 LEAIIMPLRRPDLFTGVRCPPRGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWVGDA 327
            .|.:|:|..||:||||:|.|.:|:|||||||.||||:|:::|::..|.|.:|:.:|||||:|||.
  Fly   496 QEMVILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDG 560

  Fly   328 EKLVKTLFAVAAAHQPAIIFIDEVDSLLSKRSANENESTLRLKNEFLIHLDGAASNEE-IRVLVI 391
            ||||:.|||||...||:||||||||||||:||::|:|::.|||.|||:..||...|.: .|::|:
  Fly   561 EKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHEASRRLKTEFLVEFDGLPGNPDGDRIVVL 625

  Fly   392 GATNRPQELDEAVRRRFVRRLYVPLPTREARQKIIEKLIHQVKHNLDVRQVIELAELTDGYSGAD 456
            .|||||||||||..|||.:|:||.||..:.|:.::.:|:.:....||...:..||::||||||:|
  Fly   626 AATNRPQELDEAALRRFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEALRRLAKITDGYSGSD 690

  Fly   457 VDTLCRYASMAPLRSLTPDQMEVIETHQLPAVTMDDFKQALRVISKSVSSEDCKQFEAWNEIYG 520
            :..|.:.|::.|:|.|..:|::.::...:.|:|..||..:|:.|.:||:.:....:|.|::.||
  Fly   691 LTALAKDAALEPIRELNVEQVKCLDISAMRAITEQDFHSSLKRIRRSVAPQSLNSYEKWSQDYG 754

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fign	NP_608763.2	PH-like	<4..50	CDD:473070	12/44 (27%)
		P-loop containing Nucleoside Triphosphate Hydrolases	229..414	CDD:476819	102/185 (55%)
		AAA_lid_3	444..495	CDD:465537	19/50 (38%)
		Vps4_C	<480..520	CDD:462762	10/39 (26%)
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	7/23 (30%)
		RecA-like_spastin	484..648	CDD:410932	95/163 (58%)
		AAA_lid_3	676..727	CDD:465537	17/50 (34%)
		Vps4_C	<722..754	CDD:462762	9/31 (29%)