DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fign and Nsf2

DIOPT Version :9

Sequence 1:	NP_001259995.1	Gene:	Fign / 33544	FlyBaseID:	FBgn0031519	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_001287318.1	Gene:	Nsf2 / 41694	FlyBaseID:	FBgn0266464	Length:	752	Species:	Drosophila melanogaster

Alignment Length:	445	Identity:	110/445 - (24%)
Similarity:	189/445 - (42%)	Gaps:	89/445 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 STYPVQQAVKSRP---------------EGQFPESRNNSTKKIDAQQYSSESSSQ-SGFGFRTAR 159
            :|..:.|.:..||               |..|.:.:..:.:..|:.:.:.|...| :|......:
  Fly    76 ATLSINQEIDVRPYRFDASADIITLVSFETDFLQKKTTTQEPYDSDEMAKEFLMQFAGMPLTVGQ 140

  Fly   160 EQLIMDELKKKNRQATSEVDAVPTGMMNFRKKTLGGKRTVSSN------FVSPVAQNDNSTSSRS 218
            ..:...:.||....|...::||.       .:|:|.....:.|      ..:.|.|.:.:.:|
  Fly   141 TLVFQFKDKKFLGLAVKTLEAVD-------PRTVGDSLPKTRNVRFGRILGNTVVQFEKAENS-- 196

  Fly   219 SSIPPALAHLDSKMVDHILGESM----HDFKPVAWEDIAGLESA-KSTFLEAIIMPLRRPDLF-- 276
                  :.:|..:....|:.:|:    .||..:.   |.||:.. .:.|..|....:..|:|.
  Fly   197 ------VLNLQGRSKGKIVRQSIINPDWDFGKMG---IGGLDKEFNAIFRRAFASRVFPPELVEQ 252

  Fly   277 TGVRCPPRGVLLFGPPGTGKTLIAKSIASQAKAKFFSI-NPSSLTSKWVGDAEKLVKTLFAVAAA 340
            .|:: ..:|:||:|||||||||:|:.|.:...|:...| |...:..|:||::|..::.|||.|..
  Fly   253 LGIK-HVKGILLYGPPGTGKTLMARQIGTMLNAREPKIVNGPQILDKYVGESEANIRRLFAEAEE 316

  Fly   341 HQPA--------IIFIDEVDSLLSKRSANENESTLR--LKNEFLIHLDGAASNEEI-RVLVIGAT 394
            .:..        ||..||:|::...|.:....|.:.  :.|:.|..:||.   |:: .:||||.|
  Fly   317 EEKRLGPNSGLHIIIFDEIDAICKARGSVAGNSGVHDTVVNQLLAKIDGV---EQLNNILVIGMT 378

  Fly   395 NRPQELDEAVRR--RFVRRLYVPLPTREARQKIIEKLIHQVKHNLDVRQVI------ELAELTDG 451
            ||...:|||:.|  |...::.:.||..:.|.:|:.  || .|...|..::.      |:|..|..
  Fly   379 NRRDMIDEALLRPGRLEVQMEISLPNEQGRVQILN--IH-TKRMRDFNKIASDVDNNEIAAKTKN 440

  Fly   452 YSGADVDTLCRYASMAPLRSL---------TPDQMEVIETHQLPAVTMDDFKQAL 497
            :|||:::.|.|.|....:..|         .|:.||.:.      ||..||..||
  Fly   441 FSGAELEGLVRAAQSTAMNRLIKADSKVHVDPEAMEKLR------VTRADFLHAL 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fign	NP_001259995.1	AAA	282..418	CDD:214640	50/149 (34%)
		AAA	286..416	CDD:278434	48/143 (34%)
		Vps4_C	<480..520	CDD:286426	6/18 (33%)
Nsf2	NP_001287318.1	CDC48_N	9..89	CDD:215012	3/12 (25%)
		CDC48_2	117..>170	CDD:215011	11/59 (19%)
		AAA	259..404	CDD:214640	50/147 (34%)
		AAA	261..402	CDD:278434	48/143 (34%)
		AAA	543..674	CDD:214640
		P-loop_NTPase	544..>613	CDD:304359
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900