Protein Alignment Fign and vps4b

DIOPT Version :10

• Sequence 1: NP_608763.2
• Gene: Fign / 33544
• FlyBaseID: FBgn0031519
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: XP_073770081.1
• Gene: vps4b / 393880
• ZFINID: ZDB-GENE-040426-1235
• Length: 562
• Species: Danio rerio
• Alignment Length: 561
• Identity: 171/561 - (30%)
• Similarity: 264/561 - (47%)
• Gaps: 107/561 - (19%)

  Fly    11 KLLLICQQTRSSSESIHF-AALKDHHARL-----------QACESMEKAMKERCQKKITMSRRTK 63
            |.:.|.|:.....::.|| .|:|.:|..:           |..|..:| ::|:|::.:......:
Zfish    55 KAIAIAQKASEEDQAGHFEEAIKSYHHAVKYFLHIIKREPQGKEGNQK-IREKCKQYLDRVEELQ 118

  Fly    64 RGITHAGYLFEMPHNS-VFEPECRGFYESCQQTEMASSDLQAPALEVSSTYPVQQAVKSRPEGQF 127
                  .||.:....| .:|.:.........|.:.|.:..:|..|       .|.||:     .|
Zfish   119 ------DYLDKKEATSCCYESKAIDLANKASQEDKAENYEEALRL-------YQHAVQ-----YF 165

  Fly   128 PESRNNSTKKIDAQQYSSESSSQSGFGFRTAREQLIMDELKKKNRQATSEVDAVPTGMMNFRKKT 192
            ..     ..|.:||...::.|.::.......|.:.:.:.||||.:.....|
Zfish   166 LH-----VVKYEAQGDKAKQSIRAKCAEYLDRAEKLKEYLKKKEKAPAKPV-------------- 211

  Fly   193 LGGKRTVSSNFVSPVAQNDNSTSSRSSSIPPALAHLDSKMVDHILGESMHDFKPVAWEDIAGLES 257
               |.:.|         ||....|.....|.     ..|..:.:.|..:.:...:.|.|:||||.
Zfish   212 ---KESQS---------NDKGNESDGEEDPE-----KKKFQNQLSGAIVMEKPNIKWNDVAGLEG 259

  Fly   258 AKSTFLEAIIMPLRRPDLFTGVRCPPRGVLLFGPPGTGKTLIAKSIASQA-KAKFFSINPSSLTS 321
            ||....||:|:|::.|.||||.|.|.||:||||||||||:.:||::|::| .:.||||:.|.|.|
Zfish   260 AKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVATEANNSTFFSISSSDLVS 324

  Fly   322 KWVGDAEKLVKTLFAVAAAHQPAIIFIDEVDSLLSKRSANENESTLRLKNEFLIHLDGAASNEEI 386
            ||:|::|||||:||.:|..|:|:||||||:|||...||.||:|:..|:|.|||:.:.|..::.|
Zfish   325 KWLGESEKLVKSLFTLAREHKPSIIFIDEIDSLCGSRSENESEAARRIKTEFLVQMQGVGNDNE- 388

  Fly   387 RVLVIGATNRPQELDEAVRRRFVRRLYVPLPTREARQKIIEKLIHQVKHNLDVRQVIELAELTDG 451
            .:||:||||.|..||.|:||||.:|:|:|||...||..:.:..:....::|.....:.|.:.|||
Zfish   389 GILVLGATNIPWTLDSAIRRRFEKRIYIPLPEEHARSFMFKLNLGTTPNSLTESDFMTLGKKTDG 453

  Fly   452 YSGADVDTLCRYASMAPLRS-------------------------LTP-----------DQMEVI 480
            |||||:..:.|.|.|.|:|.                         |||           ..|||.
Zfish   454 YSGADISIIVRDALMQPVRKVQSATHFKQVRGPSRSDPNVIVDDLLTPCSPGDPQAKEMTWMEVP 518

  Fly   481 ETHQL-PAVTMDDFKQALRVISKSVSSEDCKQFEAWNEIYG 520
            ....| |.|:|.|..::|.....:|:.:|.::.:.:.|.:|
Zfish   519 GEKLLEPIVSMSDMLRSLSNTKPTVNEQDLEKLKKFTEDFG 559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fign	NP_608763.2	PH-like	<4..50	CDD:473070	11/50 (22%)
		P-loop containing Nucleoside Triphosphate Hydrolases	229..414	CDD:476819	93/185 (50%)
		AAA_lid_3	444..495	CDD:465537	25/87 (29%)
		Vps4_C	<480..520	CDD:462762	9/40 (23%)
vps4b	XP_073770081.1	None