DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fign and Spast

DIOPT Version :9

Sequence 1:	NP_001259995.1	Gene:	Fign / 33544	FlyBaseID:	FBgn0031519	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	XP_008762708.1	Gene:	Spast / 362700	RGDID:	1308494	Length:	614	Species:	Rattus norvegicus

Alignment Length:	473	Identity:	171/473 - (36%)
Similarity:	263/473 - (55%)	Gaps:	72/473 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 YESCQQTE--------MASSDLQAPALEVSSTYPVQQAVKSRPEGQFPESRNNSTKKIDAQQYSS 145
            ||..::.:        ||...||.    :....||.|..||:.: .:.||.|.:.:       :.
  Rat   169 YERARRLQAKMMTNLVMAKDRLQL----LEKLQPVLQFSKSQTD-VYNESTNLTCR-------NG 221

  Fly   146 ESSSQSGFGFRTAREQLIMDELKKKNRQATSEVDAVPTGMMNFRKKTL---------GGKRTVSS 201
            ...|:||             .:.||....|...:::|      |.||:         |..|..|.
  Rat   222 HLQSESG-------------AVPKKKDPLTHASNSLP------RSKTVMKSGSTGLSGHHRAPSC 267

  Fly   202 NFVS----------PVAQNDNSTSSRSSSIPPA--------------LAHLDSKMVDHILGESMH 242
            :.:|          |.|.....||..:.:..|:              ..::||.:.:.|:.|.:.
  Rat   268 SGLSMVSGARPGSGPAATTHKGTSKPNRTNKPSTPTTAVRKKKDLKNFRNVDSNLANLIMNEIVD 332

  Fly   243 DFKPVAWEDIAGLESAKSTFLEAIIMPLRRPDLFTGVRCPPRGVLLFGPPGTGKTLIAKSIASQA 307
            :...|.::||||.|.||....|.:|:|..||:||||:|.|.||:|||||||.|||::||::|:::
  Rat   333 NGTAVKFDDIAGQELAKQALQEIVILPSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAES 397

  Fly   308 KAKFFSINPSSLTSKWVGDAEKLVKTLFAVAAAHQPAIIFIDEVDSLLSKRSANENESTLRLKNE 372
            .|.||:|:.:|||||:||:.||||:.|||||...||:|||||||||||.:|...|::::.|||.|
  Rat   398 NATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTE 462

  Fly   373 FLIHLDGAASNEEIRVLVIGATNRPQELDEAVRRRFVRRLYVPLPTREARQKIIEKLIHQVKHNL 437
            |||..||..|..:.||||:|||||||||||||.|||::|:||.||..|.|..:::.|:.:....|
  Rat   463 FLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPL 527

  Fly   438 DVRQVIELAELTDGYSGADVDTLCRYASMAPLRSLTPDQMEVIETHQLPAVTMDDFKQALRVISK 502
            ..:::.:||.:||||||:|:..|.:.|::.|:|.|.|:|::.:...::..:.:.||.::|:.|.:
  Rat   528 TQKELAQLARMTDGYSGSDLTALAKDAALGPIRELKPEQVKNMSASEMRNIRLSDFTESLKKIKR 592

  Fly   503 SVSSEDCKQFEAWNEIYG 520
            |||.:..:.:..||:.:|
  Rat   593 SVSPQTLEAYIRWNKDFG 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fign	NP_001259995.1	AAA	282..418	CDD:214640	85/135 (63%)
		AAA	286..416	CDD:278434	81/129 (63%)
		Vps4_C	<480..520	CDD:286426	9/39 (23%)
Spast	XP_008762708.1	MIT_spastin	114..193	CDD:239142	6/27 (22%)
		P-loop_NTPase	339..>395	CDD:304359	32/55 (58%)
		AAA	372..508	CDD:214640	85/135 (63%)
		AAA	376..506	CDD:278434	81/129 (63%)
		Vps4_C	<578..610	CDD:286426	9/31 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1176820at2759
OrthoFinder	1	1.000	-	-		FOG0001088
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100722
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720