Protein Alignment Fign and Katnal2

DIOPT Version :10

• Sequence 1: NP_608763.2
• Gene: Fign / 33544
• FlyBaseID: FBgn0031519
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_001419361.1
• Gene: Katnal2 / 307253
• RGDID: 1564708
• Length: 537
• Species: Rattus norvegicus
• Alignment Length: 558
• Identity: 170/558 - (30%)
• Similarity: 281/558 - (50%)
• Gaps: 94/558 - (16%)

  Fly    26 IHFAALKDHHARLQACESMEKAMKERCQKK----ITMSRRTKRGITHAGYLFEMPHNSVFEPECR 86
            :.:..||..|   ||.|:.|  |:...::|    :.:...|:.|...|.       |::.|....
  Rat     3 LSYQTLKLTH---QAREAYE--MRTEARRKNLLILILHYLTQEGYMDAA-------NALEEETKL 55

  Fly    87 GF--YESCQQTEMASSDLQAPALEVSSTY----------------PVQQAVKSRPEGQFPESRNN 133
            |.  :|.|...     ||:...:|..|.|                .|:..:.||..|:.....|:
  Rat    56 GLRRFEVCDNV-----DLETILMEYESYYFVKFQKYPKVVKKASDQVENNISSRSGGKNKRLTND 115

  Fly   134 STK---KIDAQQYSSESSSQSGFGFRTAREQLIMDELKKK---NRQATS---------------E 177
            :.:   ||..|:...::|:     .:|...:.:.:..|::   |.||.|               |
  Rat   116 NCQNLPKIYHQKSRPKTST-----VKTGDTKSVKEHPKQESVTNAQAESSDFGLNISKIHKDSPE 175

  Fly   178 VDAVPT--GMMNFRKKTLGGKRTVSSNFVSPVAQNDNSTSSRSSSIPPALAHLDSKM--VDHILG 238
            ..|.|.  .:::||.......:..:|.:.....:.:...|.|......|...::|:|  :..::.
  Rat   176 EKAHPRRGQIIDFRGLLTDAIKGATSEYALNTFECNPDPSERLLKPLSAFIGMNSEMRELAAVVS 240

  Fly   239 ESMHDFKP-VAWEDIAGLESAKSTFLEAIIMPLRRPDLFTGVRCPPRGVLLFGPPGTGKTLIAKS 302
            ..::...| :.|.||.||::||....||::.|:|.|.||||:..|.:|:||:|||||||||:||:
  Rat   241 RDIYLHNPNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTGILSPWKGLLLYGPPGTGKTLLAKA 305

  Fly   303 IASQAKAKFFSINPSSLTSKWVGDAEKLVKTLFAVAAAHQPAIIFIDEVDSLLSKRS---ANENE 364
            :|::.|..||:|:.|::.|||.||:||||:.||.:|..|.|:.||:||::|::|:|.   ..|:|
  Rat   306 VATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSQRGMVPGGEHE 370

  Fly   365 STLRLKNEFLIHLDGAASNEEIRVLVIGATNRPQELDEAVRRRFVRRLYVPLPTREARQKIIEKL 429
            .:||:|.|.|:.:||.|.:|:: |.|:.|:|.|.|||.|:.||..:|:.|.||::||||.:|...
  Rat   371 GSLRMKTELLVQMDGLARSEDL-VFVLAASNLPWELDCAMLRRLEKRILVDLPSQEARQAMIYHW 434

  Fly   430 IHQV--KHNLDVRQVIE---LAELTDGYSGADVDTLCRYASMAPLRSLTPDQMEVIETH------ 483
            :..|  .|.|::|..:|   |::.|:||||:|:..:||.|:|.|:|.:    ..|:|.|
  Rat   435 LPPVSKNHALELRTQLEYSVLSQETEGYSGSDIKLVCREAAMRPVRKI----FNVLENHQSESSN 495

  Fly   484 ----QLPAVTMDDFKQALRVISKSVSSEDCKQFEAWNE 517
                ||..||.:||...| ..:|..:....:::.||.|
  Rat   496 LLGIQLDTVTTEDFLDVL-AHTKPSAKNLTERYLAWQE 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fign	NP_608763.2	PH-like	<4..50	CDD:473070	8/23 (35%)
		P-loop containing Nucleoside Triphosphate Hydrolases	229..414	CDD:476819	84/190 (44%)
		AAA_lid_3	444..495	CDD:465537	23/63 (37%)
		Vps4_C	<480..520	CDD:462762	13/48 (27%)
Katnal2	NP_001419361.1	LisH	25..55	CDD:128913	6/36 (17%)
		RPT1	184..525	CDD:440835	127/346 (37%)
		RecA-like_VPS4-like	255..419	CDD:410917	79/164 (48%)