DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fign and Fignl1

DIOPT Version :9

Sequence 1:	NP_001259995.1	Gene:	Fign / 33544	FlyBaseID:	FBgn0031519	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_001011913.1	Gene:	Fignl1 / 289777	RGDID:	1307112	Length:	677	Species:	Rattus norvegicus

Alignment Length:	577	Identity:	213/577 - (36%)
Similarity:	307/577 - (53%)	Gaps:	116/577 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 LQACESMEKAMKERCQKKITMSRRTKRGITHAGYLFEMPHNSVFEPECRGFYE------SCQQTE 96
            :||.:..::::.|.....:.|.:...        :||:|...|    |.|..|      |...||
  Rat   120 MQAGQKFKESLLEPADASVVMCKEPT--------IFEVPQLGV----CGGSEEADLLSSSVHGTE 172

  Fly    97 ----MASSDLQAPALEVSSTYPVQQAVK-----SRPEGQ---------------------FPESR 131
                :..:.|:....: |:.:|:....|     |.|.|:                     ||::.
  Rat   173 KTQAIPGNSLRCSPFQ-STLFPMATNTKTCLTSSAPSGESTTATFHRTPLFGNTKKEPQSFPKTS 236

  Fly   132 NN---------------------------------STKKIDAQQYSSESSSQ----SGFGFRTAR 159
            ..                                 |...::.....:|.|.|    |...|:||:
  Rat   237 TGLNMFLSNPSCVPSGCENPRERKAFNDSDTINMLSNPTLNKAPSKTEDSGQREDNSLPTFKTAK 301

  Fly   160 EQLIMDELKKKNR-QATSEVDAVPTGMMNFR---KKTLGGKRT--VSSNFVSPVA-------QND 211
            |||..|:.|:.:: |.||:         :|.   ||:||..|:  :...||.||:       ||.
  Rat   302 EQLWADQKKRSHQSQHTSK---------SFNGAIKKSLGAGRSRGIFGKFVPPVSNKQDGSEQNG 357

  Fly   212 N--STSSRSSSIPPA------LAHLDSKMVDHILGESMHDFKPVAWEDIAGLESAKSTFLEAIIM 268
            |  ..|||:.|..||      |.:::.:||:.|:.|.|....||.||||||:|.||:|..|.::.
  Rat   358 NVKPKSSRAGSAEPAHLTDDRLKNVEPRMVELIMNEIMDHGPPVHWEDIAGVEFAKATIKEIVVW 422

  Fly   269 PLRRPDLFTGVRCPPRGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWVGDAEKLVKT 333
            |:.|||:|||:|.||:|:|||||||||||||.|.||||:.|.||||:.|||||||||:.||:|:.
  Rat   423 PMMRPDIFTGLRGPPKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRA 487

  Fly   334 LFAVAAAHQPAIIFIDEVDSLLSKRSANENESTLRLKNEFLIHLDGAASNEEIRVLVIGATNRPQ 398
            |||||...|||:|||||:|||||:|...|:||:.|:|.|||:.||||.::.|.|:||:|||||||
  Rat   488 LFAVARCQQPAVIFIDEIDSLLSQRGDGEHESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQ 552

  Fly   399 ELDEAVRRRFVRRLYVPLPTREARQKIIEKLIHQVKHNLDVRQVIELAELTDGYSGADVDTLCRY 463
            |:|||.|||.|:|||:|||...||::|:..|:.:.:..|...:...:.:.:||:||||:..|||.
  Rat   553 EIDEAARRRLVKRLYIPLPEASARKQIVVNLMSKEQCCLTDEETELVVQQSDGFSGADMTQLCRE 617

  Fly   464 ASMAPLRSLTPDQMEVIETHQLPAVTMDDFKQALRVISKSVSSEDCKQFEAWNEIYG 520
            ||:.|:|||....:..|...|:..:...||:.|.|.:..|||.:|.:.:|.||:.:|
  Rat   618 ASLGPIRSLHTADIATISPDQVRPIAYIDFENAFRTVRPSVSPKDLELYENWNKTFG 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fign	NP_001259995.1	AAA	282..418	CDD:214640	93/135 (69%)
		AAA	286..416	CDD:278434	88/129 (68%)
		Vps4_C	<480..520	CDD:286426	13/39 (33%)
Fignl1	NP_001011913.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	203..232		3/28 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..324		17/83 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	337..378		13/40 (33%)
		RecA-like_Figl-1	383..568	CDD:410933	116/184 (63%)
		AAA_lid_3	593..>624	CDD:407720	12/30 (40%)
		Vps4_C	<634..674	CDD:401324	13/39 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351754
Domainoid	1	1.000	186	1.000	Domainoid score	I3279
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11063
Inparanoid	1	1.050	334	1.000	Inparanoid score	I2327
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1176820at2759
OrthoFinder	1	1.000	-	-		FOG0001088
OrthoInspector	1	1.000	-	-		otm45286
orthoMCL	1	0.900	-	-		OOG6_100722
Panther	1	1.100	-	-	LDO	PTHR23074
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1766
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.760