DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fign and nsf-1

DIOPT Version :9

Sequence 1:	NP_001259995.1	Gene:	Fign / 33544	FlyBaseID:	FBgn0031519	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_001076603.1	Gene:	nsf-1 / 266842	WormBaseID:	WBGene00003818	Length:	824	Species:	Caenorhabditis elegans

Alignment Length:	496	Identity:	125/496 - (25%)
Similarity:	214/496 - (43%)	Gaps:	93/496 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 RTKRGITHAGYLFEMPHNSVFEPECRGFYESCQQTEMASSDLQAPALEVSSTYPVQQAVKSR-PE 124
            |...|..| .|:|.:.::...:|....|  .....:.|:..|.........|:...:.|.|. ..
Worm   100 RVNPGPAH-HYIFSIRNDGSIKPGEIAF--GVPHRKWAALSLDQEVRVTPFTFQQSEYVGSMILT 161

  Fly   125 GQFPESRNNSTKKIDAQQYSSESSSQ-SGFGFRTAREQLIMDELKKKNRQATSEVDAVPTGMMNF 188
            ..|...:|.:::.::|...:.|.|.| .|..|....:.....|.|:||:  |..:..|...:..|
Worm   162 ADFNAKKNVTSEPLNADLMAREFSIQFGGQAFSKGMQMAFRFEDKEKNK--THTLSLVVKSIEGF 224

  Fly   189 RKKTLGGKRTVSSNFVSPVAQNDNSTSSRSSSI------PPALAHLDSK------MVDHILGESM 241
               .:|.....:|.     |.|.:|::::...|      |.::...|.:      ::....|:|.
Worm   225 ---DIGKAAAAASG-----ASNTDSSATKPKQIEAGELLPNSVIVFDKEEGSMLNLIGKSKGKSA 281

  Fly   242 H--------DFKPVAWEDIAGLESAKS-TFLEAIIMPLRRPDLF--TGVRCPPRGVLLFGPPGTG 295
            :        ||:.:.   |.||::..| .|..|....:..|:..  .|:: ..||:|||||||||
Worm   282 YRSIINPDWDFQQMG---IGGLDTEFSHIFRRAFASRVFPPEFIEQLGMK-HVRGILLFGPPGTG 342

  Fly   296 KTLIAKSIASQAKAKFFSI-NPSSLTSKWVGDAEKLVKTLFAVA-----------AAHQPAIIFI 348
            |||:|:.|.....|:...| |...:..|:||::|..|:.|||.|           ..|   ||..
Worm   343 KTLMARQIGKMLNAREPKIVNGPQILDKYVGESESNVRKLFADAEEEWRRCGANSGLH---IIIF 404

  Fly   349 DEVDSLLSKRSANENESTLR--LKNEFLIHLDGAASNEEI-RVLVIGATNRPQELDEAVRR--RF 408
            ||:|::..:|.:....|::.  :.|:.|..:||.   |:: .:||||.|||...:|||:.|  |.
Worm   405 DEIDAICKQRGSMAGSSSVHDTVVNQLLSKMDGV---EQLNNILVIGMTNRRDMIDEALLRPGRL 466

  Fly   409 VRRLYVPLPTREARQKIIEKLIH--------QVKHNLDVRQVIELAELTDGYSGADVDTLCRYAS 465
            ..::.|.||....|.:|::  ||        ::..|:|:.   ::::.|..:|||:::.|.|.|.
Worm   467 EVQMEVSLPDETGRLQILK--IHTARMREYNKMDPNVDLE---DISKRTKNFSGAELEGLVRAAQ 526

  Fly   466 MAPLRSLT---------PDQMEVIETHQLPAVTMDDFKQAL 497
            .:.:..|.         ||.:|.:      |:...||..||
Worm   527 SSAMNRLVKAGGKAQADPDAIEKL------AINSGDFDYAL 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fign	NP_001259995.1	AAA	282..418	CDD:214640	55/152 (36%)
		AAA	286..416	CDD:278434	52/146 (36%)
		Vps4_C	<480..520	CDD:286426	5/18 (28%)
nsf-1	NP_001076603.1	CDC48_N	68..147	CDD:215012	9/49 (18%)
		CDC48_2	174..>222	CDD:215011	12/49 (24%)
		AAA	331..476	CDD:214640	55/150 (37%)
		AAA	333..474	CDD:278434	52/146 (36%)
		AAA	609..746	CDD:99707
		AAA	614..748	CDD:214640
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000