DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fign and Iqca1l

DIOPT Version :9

Sequence 1:	NP_001259995.1	Gene:	Fign / 33544	FlyBaseID:	FBgn0031519	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_808344.3	Gene:	Iqca1l / 231045	MGIID:	3045319	Length:	825	Species:	Mus musculus

Alignment Length:	489	Identity:	112/489 - (22%)
Similarity:	195/489 - (39%)	Gaps:	126/489 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 QQTRSSSESIHFAALKDHHARLQACESMEKAMKERCQKKITMSRRTKRGITHAGYLFE-MPHNSV 80
            :|.|...|:....:.|....:.:..:..||..||:.:||:...:..|    ....:|. :|..|:
Mouse   335 EQVRLDLEAQAQESRKKDQEKKEKNKEKEKEKKEKKKKKVKEEKVKK----EPEVMFRVLPSKSI 395

  Fly    81 FEPECRGFYESCQQTEMASSDLQAPALEVSSTYPVQQAVKSRPEGQFPESRNNSTKKIDAQQYSS 145
              |.....:|                 |.:|.:      |||.:.:.|      ::..|::....
Mouse   396 --PVINAGHE-----------------EYTSVW------KSRYDNKHP------SQNFDSETLRE 429

  Fly   146 ESSSQSGFGFRTAREQLIMDELKKKNRQATSEVDAVPTGMMNFRKKTLGGK-------------- 196
            |...|.....|...::|:..|||.. |.|   ||...|..:...||. |||
Mouse   430 EKRKQVEMEIRVQVDELMRQELKNL-RLA---VDREETRPLKSPKKK-GGKKSGKKKKEKDLTPD 489

  Fly   197 RTVSSNF-----------VSPVAQND--------NSTSSRSSSIP-PALAHLDSKMVDH-ILGES 240
            |:|.|.|           .:.|..:|        .||.:.::.:| |:|..:...|..: :|...
Mouse   490 RSVDSLFEELVIIGLIKKSALVTLSDYIGDCLYLGSTLTLANKMPMPSLFDIRQNMALYGVLRLG 554

  Fly   241 MHDFKPVAWEDIAGLESAKSTFLEAIIMPLRRPDLFTGVRCPPRGVLLFGPPGTGKTLIAKSIAS 305
            .||...:|                    ||            .|.:||.||.|.||.::.:::.:
Mouse   555 SHDIHTMA--------------------PL------------VRSILLVGPSGMGKKMLVQAVCT 587

  Fly   306 QAKAKFFSINPSSLTSKWVG--DAEKLVKTLFAVAAAHQPAIIFIDEVDSLLSKRSANENESTL- 367
            :..|..|.::|.:|..|:.|  .|:.||..:|.||...||::|:|...:....|:...| |.|:
Mouse   588 ETGANLFDLSPDNLMGKYPGKNGAQLLVHIVFKVARLLQPSVIWIGNTEKTFYKKVPKE-ERTMD 651

  Fly   368 --RLKNEFLIHLDGAASNEEIRVLVIGATNRPQELD-EAVRRRFVRRLYVPLPTREARQKIIEKL 429
              |:|.:.:......:..:  ||::||.|.|||..: :.:.|.:.|.|::|.|...:|..:.:::
Mouse   652 PKRIKKDLMRATKQLSPGD--RVMLIGTTERPQLAEMKGLCRFYERILFIPRPDYASRYVLWKRM 714

  Fly   430 IH------QVKHNLDVRQVIELAELTDGYSGADV 457
            |.      |:..:|||.   .||.::|||:.:.:
Mouse   715 IESQGRGVQLTSSLDVS---ALARVSDGYTPSHI 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fign	NP_001259995.1	AAA	282..418	CDD:214640	42/141 (30%)
		AAA	286..416	CDD:278434	40/135 (30%)
		Vps4_C	<480..520	CDD:286426
Iqca1l	NP_808344.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	344..378		7/33 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	459..487		7/28 (25%)
		SpoVK	<566..745	CDD:223540	54/184 (29%)
		AAA	568..701	CDD:278434	40/135 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900