DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fign and cdc-48.1

DIOPT Version :9

Sequence 1:	NP_001259995.1	Gene:	Fign / 33544	FlyBaseID:	FBgn0031519	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_496273.1	Gene:	cdc-48.1 / 174624	WormBaseID:	WBGene00007352	Length:	809	Species:	Caenorhabditis elegans

Alignment Length:	512	Identity:	126/512 - (24%)
Similarity:	220/512 - (42%)	Gaps:	113/512 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 EPECRGFYESCQQTEMA-----SSDLQAPALE----------VSSTYPVQQAVKSRPE------- 124
            |...|..:|.|::.:.|     ..|..||..|          ||....:...||.|..
Worm   289 ESNLRKAFEECEKNQPAILFIDEIDAIAPKREKTNGEVERRIVSQLLTLMDGVKGRSNLVVIAAT 353

  Fly   125 -------------GQF--------PESRNN------STKK------IDAQQYSSESSSQSGFGFR 156
                         |:|        |::...      .||.      :|.:|.::|.....|....
Worm   354 NRPNSIDGALRRFGRFDREIDIGIPDAVGRLEILRIHTKNMKLADDVDLEQIANECHGFVGADLA 418

  Fly   157 TAREQLIMDELKKKNRQATSEVDAVPTGMMNFRKKTLGGKRTVSSNFVSPVAQNDNSTSSRSSSI 221
            :...:..:.::::|......|.|.:...::|....|:                 :|...::..|.
Worm   419 SLCSEAALQQIREKMELIDLEDDQIDAEVLNSLAVTM-----------------ENFRFAQGKSS 466

  Fly   222 PPALAHLDSKMVDHILGESMHDFKPVAWEDIAGLESAKSTFLEAIIMPLRRPDLFT--GVRCPPR 284
            |.||.            |::.:.....|.||.||::.|....|.:..|:..|:.:.  |:: |.|
Worm   467 PSALR------------EAVVETPNTTWSDIGGLQNVKRELQELVQYPVEHPEKYLKFGMQ-PSR 518

  Fly   285 GVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWVGDAEKLVKTLFAVAAAHQPAIIFID 349
            |||.:||||.||||:||:||::.:|.|.||....|.:.|.|::|..|:.:|..|.|..|.::|.|
Worm   519 GVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVRDVFDKARAAAPCVLFFD 583

  Fly   350 EVDSLLSKR----SANENESTLRLKNEFLIHLDGAASNEEIRVLVIGATNRPQELDEAVRR--RF 408
            |:||:...|    ..:...::.|:.|:.|..:||  .|.:..|.:|||||||..:|.||.|  |.
Worm   584 ELDSIAKARGGGAGGDGGGASDRVINQVLTEMDG--MNAKKNVFIIGATNRPDIIDPAVLRPGRL 646

  Fly   409 VRRLYVPLPTREARQKIIEKLIHQVKHNLDVRQVIELAELTDGYSGADVDTLCRYASMAPLRSLT 473
            .:.:|:|||...:|.:|::..:.:...:.|: .:..||:.|.|:||||:..:|:.|....:|...
Worm   647 DQLIYIPLPDEASRHQILKASLRKTPLSKDL-DLTFLAKNTVGFSGADLTEICQRACKLAIRESI 710

  Fly   474 PDQMEVIETHQ-----------------LPAVTMDDFKQALRVISKSVSSEDCKQFE 513
            ..::.:.:..|                 :|.:|...|::|::...:||:..|.:::|
Worm   711 EKEIRIEKERQDRQARGEELMEDDAVDPVPEITRAHFEEAMKFARRSVTDNDIRKYE 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fign	NP_001259995.1	AAA	282..418	CDD:214640	58/141 (41%)
		AAA	286..416	CDD:278434	53/135 (39%)
		Vps4_C	<480..520	CDD:286426	9/51 (18%)
cdc-48.1	NP_496273.1	CDC48_N	31..112	CDD:280513
		CDC48	52..775	CDD:273521	126/512 (25%)
		CDC48_2	137..197	CDD:215011
		AAA	247..376	CDD:278434	16/86 (19%)
		AAA	520..654	CDD:278434	53/135 (39%)
		Vps4_C	<727..771	CDD:286426	8/41 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810