DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fign and SPATA5

DIOPT Version :9

Sequence 1:	NP_001259995.1	Gene:	Fign / 33544	FlyBaseID:	FBgn0031519	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	XP_016863314.1	Gene:	SPATA5 / 166378	HGNCID:	18119	Length:	917	Species:	Homo sapiens

Alignment Length:	488	Identity:	145/488 - (29%)
Similarity:	218/488 - (44%)	Gaps:	104/488 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 FYESCQQTEMASSDLQAPALEVSSTYPVQQAVKSRPEGQFPESRNNSTKKIDAQQYSSES----- 147
            |.:|..:|......||...|::..|             |.|.||:...|.||.:..:..|
Human   219 FEQSSMETSSLELSLQLSQLDLEDT-------------QIPTSRSTPYKPIDDRITNKASDVLLD 270

  Fly   148 ---SSQSGFG------------FRTAREQLIMDELKKKNRQATSEVDAVPTGMMNFRKKTLGGK- 196
               |...|.|            |.:|||         .|.|.|.|        ....|.::|.|
Human   271 VTQSPGDGSGLMLEEVTGLKCNFESARE---------GNEQLTEE--------ERLLKFSIGAKC 318

  Fly   197 RTVSSNFVSPVAQNDNSTSSRSSSIPPALAHLDSKMVDHILGESMHDFKPVAWEDIAGLESAKST 261
            .|.:..|:|...:.:.:...::|.                  |..:.|| |.::.|.||.|....
Human   319 NTDTFYFISSTTRVNFTEIDKNSK------------------EQDNQFK-VTYDMIGGLSSQLKA 364

  Fly   262 FLEAIIMPLRRPDLFTGVRCP-PRGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWVG 325
            ..|.|.:||::|:||.....| ||||||:||||||||:||:::|::..|....||...:.||:.|
Human   365 IREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYG 429

  Fly   326 DAEKLVKTLFAVAAAHQPAIIFIDEVDSLLSKRSANENESTLRLKNEFLIHLDGAASN-EEIRVL 389
            :.|..::.:||.|....|:||||||:|:|..||...:||...|:....|..:||..|. .|.:||
Human   430 ETEAKLRQIFAEATLRHPSIIFIDELDALCPKREGAQNEVEKRVVASLLTLMDGIGSEVSEGQVL 494

  Fly   390 VIGATNRPQELDEAVRR--RFVRRLYVPLPTREARQKIIEKLIHQVKHNLDVRQVIELAELTDGY 452
            |:||||||..||.|:||  ||.:.:.:.:|..:.|..|::||:.:|.|.|...::::||....||
Human   495 VLGATNRPHALDAALRRPGRFDKEIEIGVPNAQDRLDILQKLLRRVPHLLTEAELLQLANSAHGY 559

  Fly   453 SGADVDTLCRYAS------------------------MAPLRSLTPDQMEV--IETHQLPAVTMD 491
            .|||:..||..|:                        :..||.:...|..:  ::...|..:|:.
Human   560 VGADLKVLCNEAAGTRILKAHMYVSAFATGLTQTPQGLCALRRILKKQPNLPDVKVAGLVKITLK 624

  Fly   492 DFKQALRVISKSVSSE---DCKQFEAWNEIYGV 521
            ||.||:..|..|...|   |.... :|::|.|:
Human   625 DFLQAMNDIRPSAMREIAIDVPNV-SWSDIGGL 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fign	NP_001259995.1	AAA	282..418	CDD:214640	63/139 (45%)
		AAA	286..416	CDD:278434	59/132 (45%)
		Vps4_C	<480..520	CDD:286426	12/42 (29%)
SPATA5	XP_016863314.1	CDC48_N	65..133	CDD:389870
SPATA5	XP_016863314.1	CDC48	<323..913	CDD:273521	115/354 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810