Protein Alignment Fign and Kat60

DIOPT Version :10

• Sequence 1: NP_608763.2
• Gene: Fign / 33544
• FlyBaseID: FBgn0031519
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: XP_003435935.1
• Gene: Kat60 / 1281382
• VectorBaseID: AGAMI1_001618
• Length: 573
• Species: Anopheles gambiae
• Alignment Length: 579
• Identity: 168/579 - (29%)
• Similarity: 282/579 - (48%)
• Gaps: 116/579 - (20%)

  Fly    39 QACESMEKAMKERCQKKITMSRRTKRGITHAGYLFEMPHN---SVFEPECRGFYESCQQ------ 94
            :.||:.:.|     ::...|......||.:.|.| :|...   .:.||..:|.:...||
Mosquito    12 EICENTKLA-----REMAVMGNYDSAGIYYEGVL-QMLRKLLVGLSEPLQKGKWLMIQQEINKEY 70

  Fly    95 ----------TEMASSDLQAPALEVSSTYPVQQAVKSRPEGQFPESRNNSTKKIDAQQYSSESSS 149
                      ||: :.|||...|:.....|:.:.....|...|         :.|...:...:|.
Mosquito    71 NQMKLIQKTLTEI-TMDLQNAPLQARIRTPLHETASKDPAAWF---------RADPDIWMPPASG 125

  Fly   150 QSGFG---------FRTAREQLIMDEL-----KKKNRQAT-----SEVDAVPTGMMNFRKKTLGG 195
            ..|.|         :..|.:....|..     :.::|.:|     |||:.......:....|:||
Mosquito   126 GRGGGGGGPIDPDVWAPAPDMPPPDHRRAVAPRNQSRSSTALNRKSEVNRRNAATKSASTSTVGG 190

  Fly   196 KRTVSSNFVSPVAQNDNSTS------------SRSSSIPPA------------------------ 224
            ::|:|....:......|..|            .|.|:.|.|
Mosquito   191 RKTISQTARAGGTSGMNGASRTGTLPRTKAAGQRGSTAPGASDATNGNGEKGDKEKLGDDEEGNN 255

  Fly   225 --------------LAHLDSKMVDHILGESMHDFKPVAWEDIAGLESAKSTFLEAIIMPLRRPDL 275
                          .:|.|..:||.:..:.:.....:.|:|||.|..||....||:::|:..||.
Mosquito   256 GGDTPEEVERKFEPASHADVDLVDMLERDILQKNPNIHWDDIADLHEAKRLLEEAVVLPMWMPDY 320

  Fly   276 FTGVRCPPRGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWVGDAEKLVKTLFAVAAA 340
            |.|:|.|.:|||:.||||||||::||::|::....||:::.|:||||:.|::||||:.||.:|..
Mosquito   321 FKGIRRPWKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARF 385

  Fly   341 HQPAIIFIDEVDSLLSKR-SANENESTLRLKNEFLIHLDGAASNEEIR-VLVIGATNRPQELDEA 403
            :.|:.|||||:|||.|:| |.:|:|::.|:|:|.|:.:||.:::|..: |:|:.|||.|.::|||
Mosquito   386 YAPSTIFIDEIDSLCSRRGSESEHEASRRVKSELLVQMDGVSNDEATKIVMVLAATNFPWDIDEA 450

  Fly   404 VRRRFVRRLYVPLPTREARQKIIEKLIHQVK--HNLDVRQVIELAELTDGYSGADVDTLCRYASM 466
            :|||..:|:|:|||..|.|:.:::..:.:||  .::|:|   ::|:..|||||||:..:||.|||
Mosquito   451 LRRRLEKRIYIPLPNSEGREALLKINLREVKVDESVDMR---DIADRLDGYSGADITNVCRDASM 512

  Fly   467 APLR----SLTPDQMEVIETHQLP-AVTMDDFKQALRVISKSVSSEDCKQFEAWNEIYG 520
            ..:|    .|.|:|:..:...:|. .|:..|||:|:...:||||.:|..:::.|.:.:|
Mosquito   513 MSMRRKIAGLRPEQIRQLAKEELDLPVSKQDFKEAISKCNKSVSKDDLAKYQQWMKEFG 571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fign	NP_608763.2	PH-like	<4..50	CDD:473070	3/10 (30%)
		P-loop containing Nucleoside Triphosphate Hydrolases	229..414	CDD:476819	82/186 (44%)
		AAA_lid_3	444..495	CDD:465537	21/55 (38%)
		Vps4_C	<480..520	CDD:462762	12/40 (30%)
Kat60	XP_003435935.1	Kp60-NTD	11..79	CDD:439297	14/72 (19%)
		RecA-like_KTNA1	296..461	CDD:410930	78/164 (48%)
		AAA_lid_3	485..529	CDD:465537	19/46 (41%)
		Vps4_C	<529..571	CDD:462762	12/41 (29%)