Protein Alignment Fign and Vcp

DIOPT Version :10

• Sequence 1: NP_608763.2
• Gene: Fign / 33544
• FlyBaseID: FBgn0031519
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_446316.1
• Gene: Vcp / 116643
• RGDID: 621595
• Length: 806
• Species: Rattus norvegicus
• Alignment Length: 398
• Identity: 118/398 - (29%)
• Similarity: 195/398 - (48%)
• Gaps: 57/398 - (14%)

  Fly   138 IDAQQYSSESSSQSGFGFRTAREQLIMDELKKKNRQATSEVDAVPTGMMNFRKKTLGGKRTVSSN 202
            :|.:|.::|:....|........:..:..::||......|.:.:...:||....|:
  Rat   394 VDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTM--------- 449

  Fly   203 FVSPVAQNDNSTSSRSSSIPPALAHLDSKMVDHILGESMHDFKPVAWEDIAGLESAKSTFLEAII 267
                    |:...:.|.|.|.||.            |::.:...|.||||.|||..|....|.:.
  Rat   450 --------DDFRWALSQSNPSALR------------ETVVEVPQVTWEDIGGLEDVKRELQELVQ 494

  Fly   268 MPLRRPDLFT--GVRCPPRGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWVGDAEKL 330
            .|:..||.|.  |: .|.:|||.:||||.||||:||:||::.:|.|.||....|.:.|.|::|..
  Rat   495 YPVEHPDKFLKFGM-TPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEAN 558

  Fly   331 VKTLFAVAAAHQPAIIFIDEVDSLLSKRSANENE---STLRLKNEFLIHLDGAASNEEIRVLVIG 392
            |:.:|..|....|.::|.||:||:...|..|..:   :..|:.|:.|..:||.::.:  .|.:||
  Rat   559 VREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKK--NVFIIG 621

  Fly   393 ATNRPQELDEAVRR--RFVRRLYVPLPTREARQKIIEKLIHQ--VKHNLDVRQVIELAELTDGYS 453
            |||||..:|.|:.|  |..:.:|:|||..::|..|::..:.:  |..::|:.   .||::|:|:|
  Rat   622 ATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLE---FLAKMTNGFS 683

  Fly   454 GADVDTLCRYASMAPL-------------RSLTPDQMEVIETHQLPAVTMDDFKQALRVISKSVS 505
            |||:..:|:.|....:             |...|..|||.|...:|.:..|.|::|:|...:|||
  Rat   684 GADLTEICQRACKLAIRESIESEIRRERERQTNPSAMEVEEDDPVPEIRRDHFEEAMRFARRSVS 748

  Fly   506 SEDCKQFE 513
            ..|.:::|
  Rat   749 DNDIRKYE 756

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fign	NP_608763.2	PH-like	<4..50	CDD:473070
		P-loop containing Nucleoside Triphosphate Hydrolases	229..414	CDD:476819	68/191 (36%)
		AAA_lid_3	444..495	CDD:465537	19/63 (30%)
		Vps4_C	<480..520	CDD:462762	11/34 (32%)
Vcp	NP_446316.1	CDC48	25..764	CDD:273521	118/398 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	708..727		6/18 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	768..806
		Interaction with UBXN6. /evidence=ECO:0000250	797..806
		PIM motif. /evidence=ECO:0000250|UniProtKB:P55072	802..806