DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fign and KATNA1

DIOPT Version :9

Sequence 1:	NP_001259995.1	Gene:	Fign / 33544	FlyBaseID:	FBgn0031519	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_008975.1	Gene:	KATNA1 / 11104	HGNCID:	6216	Length:	491	Species:	Homo sapiens

Alignment Length:	431	Identity:	149/431 - (34%)
Similarity:	240/431 - (55%)	Gaps:	45/431 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 ASSDLQAPALEV-SSTYPVQQAVKSRPEGQFPESRNNSTKKIDAQQYSSESSSQSGFGFRTAREQ 161
            |..||.|...|| |...||::.....|            :|..:.|||...|    .|.|.:...
Human    86 AQHDLPASEGEVWSMPVPVERRPSPGP------------RKRQSSQYSDPKS----HGNRPSTTV 134

  Fly   162 LIMDELKKKNRQATSEVDAVPTGMMNFRKKTLGGKRTVSSNFVSPVAQNDNSTSSRSSSIPPALA 226
            .:       :|.:...|.......:..|:|....|.....| .||.|..:..|:...|:
Human   135 RV-------HRSSAQNVHNDRGKAVRCREKKEQNKGREEKN-KSPAAVTEPETNKFDST------ 185

  Fly   227 HLDSKMVDHILGESMHDFKPVAWEDIAGLESAKSTFLEAIIMPLRRPDLFTGVRCPPRGVLLFGP 291
            ..|..:|:.:..:.:.....|.|:|||.|..||....||:::|:..|:.|.|:|.|.:|||:.||
Human   186 GYDKDLVEALERDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGP 250

  Fly   292 PGTGKTLIAKSIASQAKAKFFSINPSSLTSKWVGDAEKLVKTLFAVAAAHQPAIIFIDEVDSLLS 356
            |||||||:||::|::.|..||:::.|:||||:.|::||||:.||.:|..:.||.|||||:||:.|
Human   251 PGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICS 315

  Fly   357 KR-SANENESTLRLKNEFLIHLDGAASNEE-----IRVLVIGATNRPQELDEAVRRRFVRRLYVP 415
            :| ::.|:|::.|:|.|.|:.:||.....|     ..|:|:.|||.|.::|||:|||..:|:|:|
Human   316 RRGTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIP 380

  Fly   416 LPTREARQKIIEKLIHQVKHNLDVRQVIELAELTDGYSGADVDTLCRYASMAPLR----SLTPDQ 476
            ||:.:.|::::...:.:::...|| .:..:||..:||||||:..:||.||:..:|    .|||::
Human   381 LPSAKGREELLRISLRELELADDV-DLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEE 444

  Fly   477 MEVI--ETHQLPAVTMDDFKQALRVISKSVSSEDCKQFEAW 515
            :..:  |...:| .||:||:.||:.:|||||:.|.:::|.|
Human   445 IRNLSKEEMHMP-TTMEDFEMALKKVSKSVSAADIERYEKW 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fign	NP_001259995.1	AAA	282..418	CDD:214640	68/141 (48%)
		AAA	286..416	CDD:278434	64/135 (47%)
		Vps4_C	<480..520	CDD:286426	16/38 (42%)
KATNA1	NP_008975.1	Interaction with microtubules	1..185		27/122 (22%)
		Interaction with dynein and NDEL1. /evidence=ECO:0000250	1..75
		Interaction with KATNB1. /evidence=ECO:0000269\|PubMed:10751153	1..29
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	87..185		26/121 (21%)
		AAA	241..382	CDD:214640	67/140 (48%)
		AAA	245..381	CDD:278434	64/135 (47%)
		Vps4_C	<456..489	CDD:286426	15/30 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157790
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840