DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3277 and Tie1

DIOPT Version :9

Sequence 1:	NP_608762.3	Gene:	CG3277 / 33543	FlyBaseID:	FBgn0031518	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_445997.1	Gene:	Tie1 / 89806	RGDID:	621642	Length:	1137	Species:	Rattus norvegicus

Alignment Length:	874	Identity:	211/874 - (24%)
Similarity:	339/874 - (38%)	Gaps:	271/874 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 VRNAVGQAPRENATN----PTLISLVRSSEKEPEQMESHRYVTGLSEPIAM----EPLTRMRLNP 76
            |..:.||..|....|    |..::..|...|:..|:        :..|:..    .|::.:||:.
  Rat   429 VSTSGGQDSRRFKVNVKVPPVPLTAPRLLAKQSRQL--------VVSPLVSFGGDGPISSVRLHY 485

  Fly    77 NP-DGEIT------ELTTNVTLYMEKIPRLQVRWQDNLPQGTSYNVLV---------------SA 119
            .| |..||      :.:.||||.             ||...|.|||.|               |.
  Rat   486 RPQDSMITWSAIVVDPSENVTLM-------------NLKPRTGYNVRVQLSRPGEGGEGAWGPST 537

  Fly   120 VNNSRCPDAPCSEYGIKEKNASAETH---SVNLPVNP-------------------NLNVESVDC 162
            :..:.||: |..:..::..|......   |.:||..|                   ..|:.|...
  Rat   538 LMTTDCPE-PLLQPWVESWNVEGPDRLRVSWSLPSVPLSGDGFLLRLWDGARGQERRENISSPQA 601

  Fly   163 NYMF------GCQYQVIVE----TSNAMVRRSARVYIPQCLEGKCSCQLAPTPPKVLAVAKMLSN 217
            ....      |..||:.|.    |.......||.|::|  |.|       |..|:.|. |:.||:
  Rat   602 RTALLTGLTPGTHYQLDVRLYHCTLLGPASPSAHVHLP--LSG-------PPAPRHLR-AQALSD 656

  Fly   218 ETISINLSILASELLRKEQDSHLHETLRTYKMQLKINEETNPSLPWGGVLKHLM----------- 271
            ..|.:...                                :|..|.|.:.|:::
  Rat   657 SEIRLMWQ--------------------------------HPEAPPGPISKYIVEIQVAGGSGDP 689

  Fly   272 --TRVYKLSELNFRATPKGFEGVMKLGLGTQLKEKASLSLQAV------IIDPTGCEGPRSVTKV 328
              ..|.|..|.:  .|.:|      |...|:...:...|:|.:      :.:.|...|.:|.:
  Rat   690 QWMDVDKPEETS--TTVRG------LNASTRYLFRVRASVQGLGDWSNTVEETTLGNGLQSAS-- 744

  Fly   329 PVPANPVLLTEGDSVSNSIIV-----MSAMLIAIILAGLIMLLLRR----RRARTTAKLRKQEQI 384
            ||..:.|   ..|.:...:::     :||..:.|:.|.|.::.:||    ||...|.:....|:.
  Rat   745 PVQESRV---AEDGLDQQLVLAVVGSVSATCLTILAALLALVCIRRSCLHRRHTFTYQSGSGEET 806

  Fly   385 YIQTFATSAIEM-------EDNVNYVDKYVEKSQVLGLADI-FEVPHSAIQIGRMLGEGAFGQVH 441
            .:| |::..:.:       .:.::|        .||...|| ||         .::|||.||||.
  Rat   807 ILQ-FSSGTLTLTRRPKPQPEPLSY--------PVLEWEDITFE---------DLIGEGNFGQVI 853

  Fly   442 EATAINLRRMRGTTI-VAVKQLKPNPKADEVAEYLAEIEMLKGVGTHHNVVSFLGCCTIKPPYLM 505
            .|    :.:..|..: .|:|.||.....::..::..|:|:|..:|.|.|:::.||.|..:....:
  Rat   854 RA----MIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACENRGYLYI 914

  Fly   506 IMEYVNKGNLLSYLRTVRKEASKLRNRNANYTSCRPIMTRTNSTSSPKSQSVNYIELKASSQTIE 570
            .:||...||||.:||..|
  Rat   915 AIEYAPYGNLLDFLRKSR----------------------------------------------- 932

  Fly   571 MPQEDSTAHMNGIRQPHPSFAETTYTIVEDEDAFEYILDNKELHNFALQIANGMRFLEEQEITHR 635
                        :.:..|:||.        |......|.:::|..||...||||::|.|::..||
  Rat   933 ------------VLETDPAFAR--------EHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHR 977

  Fly   636 DLAARNVLIDSNKTLKISDFGLSR-HGIYTNTRTRKLPLRWLSIEAIRENVYSSKSDIWAYGVVL 699
            ||||||||:..|...||:|||||| ..:|......:||:||::||::..:||::|||:|::||:|
  Rat   978 DLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLL 1042

  Fly   700 WEIGTLGASPYPTISNDELIPFLMAGNRLERPEICTPQVYTIMLQCWLEEPEERPTFD----ALY 760
            |||.:||.:||..::..||...|..|.|:|:|..|..:||.:|.|||.:.|.|||.|.    .|.
  Rat  1043 WEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLG 1107

  Fly   761 KVLSPKTTYVDINSLSDDYVFPPISENRE 789
            ::|..:..||:: ||.:::.:..|....|
  Rat  1108 RMLEARKAYVNM-SLFENFTYAGIDATAE 1135

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3277	NP_608762.3	STYKc	426..763	CDD:214568	107/342 (31%)
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	107/338 (32%)
Tie1	NP_445997.1	ig	130..211	CDD:278476
		EGF_Lam	228..266	CDD:238012
		EGF_CA	315..346	CDD:238011
		ig	357..442	CDD:278476	4/12 (33%)
		IG_like	370..444	CDD:214653	4/14 (29%)
		fn3	450..530	CDD:278470	22/100 (22%)
		fn3	549..631	CDD:278470	12/81 (15%)
		FN3	643..735	CDD:238020	20/132 (15%)
		PTKc_Tie1	835..1131	CDD:270671	116/376 (31%)
		TyrKc	838..1106	CDD:197581	109/347 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910