DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3277 and Fgfr3

DIOPT Version :9

Sequence 1:	NP_608762.3	Gene:	CG3277 / 33543	FlyBaseID:	FBgn0031518	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	XP_006251452.1	Gene:	Fgfr3 / 84489	RGDID:	620714	Length:	804	Species:	Rattus norvegicus

Alignment Length:	691	Identity:	176/691 - (25%)
Similarity:	305/691 - (44%)	Gaps:	193/691 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 YQVIVETSNAMVRRSARVYIPQCLEGKCSCQLAPTPPKVLAVAKMLSNETISINLSILASELLRK 234
            |..:||.....:|::   |....||        .:|.:.:..|.:.:|:|     ::|.|::
  Rat   220 YTCVVENKFGSIRQT---YTLDVLE--------RSPHRPILQAGLPANQT-----AVLGSDV--- 265

  Fly   235 EQDSHLHETLRTYKMQLKINEETNPSLPWGGVLKHLMTRVYKLSELN-FRATPKG--FEGVMKLG 296
                         :...|:..:..|.:.|   |||:        |:| .:..|.|  :..|:|..
  Rat   266 -------------EFHCKVYSDAQPHIQW---LKHV--------EVNGSKVGPDGTPYVTVLKSW 306

  Fly   297 LGTQLKEKASLSLQAVIIDPTGCE---------------------GPRSVTKVPVPANPVLLTEG 340
            :...::..|.|.| |.:.:..|.|                     ||::..:..:..:     |.
  Rat   307 ISENVEADARLRL-ANVSERDGGEYLCRATNFIGVAEKAFWLRVHGPQAAEEELMEVD-----EA 365

  Fly   341 DSVSNSIIV--MSAMLIAIILAGLIMLLLRR--RRARTTAKLRKQEQIYIQTFATSAIEMEDNVN 401
            .||...::.  :...|..:::|.:.:..||.  ::...:..:.|..:..::...|.::|...::|
  Rat   366 GSVYAGVLSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKVSRFPLKRQVTVSLESNSSMN 430

  Fly   402 YVDKYVEKSQVLG-----LADI----------FEVPHSAIQIGRMLGEGAFGQVHEATAINLRRM 451
            .....|..:::..     ||::          :|:..:.:.:|:.||||.||||..|.||.:.:.
  Rat   431 SNTPLVRIARLSSGEGPVLANVSELELPADPKWELSRTRLTLGKPLGEGCFGQVVMAEAIGIDKD 495

  Fly   452 RGT--TIVAVKQLKPNPKADEVAEYLAEIEMLKGVGTHHNVVSFLGCCTIKPPYLMIMEYVNKGN 514
            |..  ..||||.||.:....::::.::|:||:|.:|.|.|:::.||.||...|..:::||..|||
  Rat   496 RTAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGN 560

  Fly   515 LLSYLRTVRKEASKLRNRNANYTSCRPIMTRTNSTSSPKSQSVNYIELKASSQTIEMPQEDSTAH 579
            |..:||     |.:....:.::.:||                              :|:|..|.
  Rat   561 LREFLR-----ARRPPGMDYSFDACR------------------------------LPEEQLTC- 589

  Fly   580 MNGIRQPHPSFAETTYTIVEDEDAFEYILDNKELHNFALQIANGMRFLEEQEITHRDLAARNVLI 644
                                           |:|.:.|.|:|.||.:|..|:..||||||||||:
  Rat   590 -------------------------------KDLVSCAYQVARGMEYLASQKCIHRDLAARNVLV 623

  Fly   645 DSNKTLKISDFGLSR--HGI--YTNTRTRKLPLRWLSIEAIRENVYSSKSDIWAYGVVLWEIGTL 705
            ..:..:||:||||:|  |.:  |..|...:||::|::.||:.:.||:.:||:|::||:||||.||
  Rat   624 TEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTL 688

  Fly   706 GASPYPTISNDELIPFLMAGNRLERPEICTPQVYTIMLQCWLEEPEERPTF----DALYKVLSPK 766
            |.||||.|..:||...|..|:|:::|..||..:|.||.:||...|.:||||    :.|.::|:..
  Rat   689 GGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAVPSQRPTFKQLVEDLDRILTVT 753

  Fly   767 TT--YVDI-----------------NSLSDDYVF-----PP 783
            :|  |:|:                 :|..||.||     ||
  Rat   754 STDEYLDLSVPFEQYSPGGQDTPSSSSSGDDSVFTHDLLPP 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3277	NP_608762.3	STYKc	426..763	CDD:214568	117/346 (34%)
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	116/342 (34%)
Fgfr3	XP_006251452.1	IGc2	51..108	CDD:197706
		IG	52..123	CDD:214652
		Ig2_FGFR	155..239	CDD:143265	5/21 (24%)
		IG_like	254..349	CDD:214653	22/127 (17%)
		Ig3_FGFR	262..350	CDD:143175	19/115 (17%)
		PTKc_FGFR3	457..790	CDD:173652	127/399 (32%)
		Pkinase_Tyr	470..746	CDD:285015	116/342 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810