DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3277 and Fgfr1

DIOPT Version :9

Sequence 1:	NP_608762.3	Gene:	CG3277 / 33543	FlyBaseID:	FBgn0031518	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_077060.1	Gene:	Fgfr1 / 79114	RGDID:	620713	Length:	822	Species:	Rattus norvegicus

Alignment Length:	801	Identity:	197/801 - (24%)
Similarity:	325/801 - (40%)	Gaps:	207/801 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 SSEKEPEQMESHR-----YVTGLSEPIAMEPLTRMRLNPNPDGEITELTTNVTLYMEKIPRLQVR 102
            |.|||.:..:.:|     |.|   .|..||    .:|:..|..:    |..........|...:|
  Rat   136 SEEKETDNTKPNRRPVAPYWT---SPEKME----KKLHAVPAAK----TVKFKCPSSGTPSPTLR 189

  Fly   103 WQDNLPQGTSYNVLVSAVNNSRCPDAPCSEYGIKEKNASAETHSVNLPVNPNLNVESVDCNYMFG 167
            |   |..|..:.           ||.....|.::....|....||         |.|...||.
  Rat   190 W---LKNGKEFK-----------PDHRIGGYKVRYATWSIIMDSV---------VPSDKGNYT-- 229

  Fly   168 CQYQVIVETSNAMVRRSARVYIPQCLEGKCSCQLAPTPPKVLAVAKMLSNETISINLSILASELL 232
            |    |||.....:..:.::.:           :..:|.:.:..|.:.:|:|:::..::
  Rat   230 C----IVENEYGSINHTYQLDV-----------VERSPHRPILQAGLPANKTVALGSNV------ 273

  Fly   233 RKEQDSHLHETLRTYKMQLKINEETNPSLPWGGVLKHLMTRVYKLSELNFRATPKGFEGVMK-LG 296
                           :...|:..:..|.:.|   |||:.....|:...|.     .::.::| .|
  Rat   274 ---------------EFMCKVYSDPQPHIQW---LKHIEVNGSKIGPDNL-----PYDQILKTAG 315

  Fly   297 LGTQLKEKASLSLQAVIIDPTG---CEGPRSV----------TKVPVPANPVLLTEGDSVSNSII 348
            :.|..||...|.|:.|..:..|   |....|:          ....:...|.::|....:...|.
  Rat   316 VNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIY 380

  Fly   349 VMSAMLIAIILAGLIMLLLRR-------------RRARTTAKLRKQEQIYIQTFATSAIEMEDNV 400
            ...|.||:.::..:|:..::.             .:...:..||:|    :...|.|:..|...|
  Rat   381 CTGAFLISCMVGSVIIYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQ----VTVSADSSASMNSGV 441

  Fly   401 NYV-DKYVEKSQVLGLADI----------FEVPHSAIQIGRMLGEGAFGQVHEATAINLRRMR-- 452
            ..| ...:..|....||.:          :|:|...:.:|:.||||.||||..|.||.|.:.:
  Rat   442 LLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPN 506

  Fly   453 GTTIVAVKQLKPNPKADEVAEYLAEIEMLKGVGTHHNVVSFLGCCTIKPPYLMIMEYVNKGNLLS 517
            ..|.||||.||.:....::::.::|:||:|.:|.|.|:::.||.||...|..:|:||.:||||..
  Rat   507 RVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLRE 571

  Fly   518 YLRTVRKEASKLRNRNANYTSCRPIMTRTNSTSSPKSQSVNYIELKASSQTIEMPQEDSTAHMNG 582
            ||:.         .|......|      .|.:.:|:.|
  Rat   572 YLQA---------RRPPGLEYC------YNPSHNPEEQ--------------------------- 594

  Fly   583 IRQPHPSFAETTYTIVEDEDAFEYILDNKELHNFALQIANGMRFLEEQEITHRDLAARNVLIDSN 647
                                     |.:|:|.:.|.|:|.||.:|..::..||||||||||:..:
  Rat   595 -------------------------LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTED 634

  Fly   648 KTLKISDFGLSR--HGI--YTNTRTRKLPLRWLSIEAIRENVYSSKSDIWAYGVVLWEIGTLGAS 708
            ..:||:||||:|  |.|  |..|...:||::|::.||:.:.:|:.:||:|::||:||||.|||.|
  Rat   635 NVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGS 699

  Fly   709 PYPTISNDELIPFLMAGNRLERPEICTPQVYTIMLQCWLEEPEERPTFDALYK------VLSPKT 767
            |.|.:..:||...|..|:|:::|..||.::|.:|..||...|.:||||..|.:      .|:...
  Rat   700 PNPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWNAVPSQRPTFKQLVEDLDRIVALTSNQ 764

  Fly   768 TYVDINSLSDDYVFPPISENR 788
            .|:|: |:..|...|...:.|
  Rat   765 EYLDL-SMPLDQDSPSFPDTR 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3277	NP_608762.3	STYKc	426..763	CDD:214568	115/348 (33%)
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	114/344 (33%)
Fgfr1	NP_077060.1	Ig1_FGFR	40..118	CDD:143174
		IG_like	41..118	CDD:214653
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..162		8/28 (29%)
		I-set	160..247	CDD:254352	24/123 (20%)
		Heparin-binding	160..177		5/24 (21%)
		Ig2_FGFR	163..247	CDD:143265	22/116 (19%)
		IG_like	262..358	CDD:214653	21/124 (17%)
		Ig3_FGFR	270..359	CDD:143175	19/117 (16%)
		PTKc_FGFR1	464..765	CDD:270678	118/367 (32%)
		Pkinase_Tyr	478..754	CDD:285015	115/342 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	770..822		4/15 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810