Protein Alignment CG3277 and TIE1

DIOPT Version :10

• Sequence 1: NP_608762.3
• Gene: CG3277 / 33543
• FlyBaseID: FBgn0031518
• Length: 789
• Species: Drosophila melanogaster
• Sequence 2: NP_005415.1
• Gene: TIE1 / 7075
• HGNCID: 11809
• Length: 1138
• Species: Homo sapiens
• Alignment Length: 847
• Identity: 200/847 - (23%)
• Similarity: 326/847 - (38%)
• Gaps: 262/847 - (30%)

  Fly    48 PEQMESHRYVTGLSEPIAMEPL---------TRMRLNPNPDGEITELTT-------NVTLYMEKI 96
            |..:.:.|.:|..|..:.:.||         :.:||:..|.....:.:|       ||||.
Human   447 PVPLAAPRLLTKQSRQLVVSPLVSFSGDGPISTVRLHYRPQDSTMDWSTIVVDPSENVTLM---- 507

  Fly    97 PRLQVRWQDNLPQGTSYNVLVS---------------AVNNSRCPD---APCSEYGIKEKNASAE 143
                     ||...|.|:|.|.               .:..:.||:   .|..| |...:.....
Human   508 ---------NLRPKTGYSVRVQLSRPGEGGEGAWGPPTLMTTDCPEPLLQPWLE-GWHVEGTDRL 562

  Fly   144 THSVNLPVNP---------------------NLNVESVDCNYMF------GCQYQVIVE----TS 177
            ..|.:||:.|                     ..||.|.......      |..||:.|:    |.
Human   563 RVSWSLPLVPGPLVGDGFLLRLWDGTRGQERRENVSSPQARTALLTGLTPGTHYQLDVQLYHCTL 627

  Fly   178 NAMVRRSARVYIPQCLEGKCSCQLAPTPPKVLAVAKMLSNETISINLSILASELLRKEQDSHLHE 242
            .......|.|.:|..         .|..|:.|. |:.||:..|         :|..|..:: |..
Human   628 LGPASPPAHVLLPPS---------GPPAPRHLH-AQALSDSEI---------QLTWKHPEA-LPG 672

  Fly   243 TLRTYKMQLKI--------------NEETNPSLPWGGVLKHLMTRVYKLSELNFRATPKGFEGVM 293
            .:..|.:::::              .|||:.      :::.|......|  ...||:.:|
Human   673 PISKYVVEVQVAGGAGDPLWIDVDRPEETST------IIRGLNASTRYL--FRMRASIQG----- 724

  Fly   294 KLGLGTQLKEKASL--SLQAVIIDPTGCEGPRSVTKVPVPA--NPVLLTEGDSVSNSIIVMSAML 354
             ||..:...|:::|  .|||        |||...::.....  ..::|....|||.:.:.:.|.|
Human   725 -LGDWSNTVEESTLGNGLQA--------EGPVQESRAAEEGLDQQLILAVVGSVSATCLTILAAL 780

  Fly   355 IAIILAGLIMLLLRRRRART----------------TAKLRKQEQIYIQTFATSAIEMEDNVNYV 403
            :.::.  :....|.|||..|                |..|.::.::..:..:...:|.|| :.:.
Human   781 LTLVC--IRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRPKLQPEPLSYPVLEWED-ITFE 842

  Fly   404 DKYVEKSQVLGLADIFEVPHSAIQIGRMLGEGAFGQVHEATAINLRRMRGTTI-VAVKQLKPNPK 467
            |                          ::|||.||||..|    :.:..|..: .|:|.||....
Human   843 D--------------------------LIGEGNFGQVIRA----MIKKDGLKMNAAIKMLKEYAS 877

  Fly   468 ADEVAEYLAEIEMLKGVGTHHNVVSFLGCCTIKPPYLMIMEYVNKGNLLSYLRTVRKEASKLRNR 532
            .::..::..|:|:|..:|.|.|:::.||.|..:....:.:||...||||.:||..|
Human   878 ENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSR--------- 933

  Fly   533 NANYTSCRPIMTRTNSTSSPKSQSVNYIELKASSQTIEMPQEDSTAHMNGIRQPHPSFAETTYTI 597
                                                              :.:..|:||.
Human   934 --------------------------------------------------VLETDPAFAR----- 943

  Fly   598 VEDEDAFEYILDNKELHNFALQIANGMRFLEEQEITHRDLAARNVLIDSNKTLKISDFGLSR-HG 661
               |......|.:::|..||...||||::|.|::..||||||||||:..|...||:|||||| ..
Human   944 ---EHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEE 1005

  Fly   662 IYTNTRTRKLPLRWLSIEAIRENVYSSKSDIWAYGVVLWEIGTLGASPYPTISNDELIPFLMAGN 726
            :|......:||:||::||::..:||::|||:|::||:||||.:||.:||..::..||...|..|.
Human  1006 VYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGY 1070

  Fly   727 RLERPEICTPQVYTIMLQCWLEEPEERPTFD----ALYKVLSPKTTYVDINSLSDDYVFPPISEN 787
            |:|:|..|..:||.:|.|||.:.|.|||.|.    .|.::|..:..||:: ||.:::.:..|...
Human  1071 RMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNM-SLFENFTYAGIDAT 1134

  Fly   788 RE 789
            .|
Human  1135 AE 1136

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	107/338 (32%)
TIE1	NP_005415.1	ig	129..210	CDD:395002
		EGF_CA	227..256	CDD:238011
		EGF_2	321..344	CDD:400365
		Ig	350..441	CDD:472250
		Ig strand B	368..372	CDD:409556
		Ig strand C	384..388	CDD:409556
		Ig strand E	409..413	CDD:409556
		Ig strand F	423..428	CDD:409556
		Ig strand G	436..439	CDD:409556
		fn3	452..536	CDD:394996	19/96 (20%)
		fn3	548..632	CDD:394996	15/84 (18%)
		FN3	644..736	CDD:238020	22/116 (19%)
		PTKc_Tie1	836..1132	CDD:270671	115/394 (29%)