DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3277 and TIE1

DIOPT Version :9

Sequence 1:	NP_608762.3	Gene:	CG3277 / 33543	FlyBaseID:	FBgn0031518	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_005415.1	Gene:	TIE1 / 7075	HGNCID:	11809	Length:	1138	Species:	Homo sapiens

Alignment Length:	847	Identity:	200/847 - (23%)
Similarity:	326/847 - (38%)	Gaps:	262/847 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 PEQMESHRYVTGLSEPIAMEPL---------TRMRLNPNPDGEITELTT-------NVTLYMEKI 96
            |..:.:.|.:|..|..:.:.||         :.:||:..|.....:.:|       ||||.
Human   447 PVPLAAPRLLTKQSRQLVVSPLVSFSGDGPISTVRLHYRPQDSTMDWSTIVVDPSENVTLM---- 507

  Fly    97 PRLQVRWQDNLPQGTSYNVLVS---------------AVNNSRCPD---APCSEYGIKEKNASAE 143
                     ||...|.|:|.|.               .:..:.||:   .|..| |...:.....
Human   508 ---------NLRPKTGYSVRVQLSRPGEGGEGAWGPPTLMTTDCPEPLLQPWLE-GWHVEGTDRL 562

  Fly   144 THSVNLPVNP---------------------NLNVESVDCNYMF------GCQYQVIVE----TS 177
            ..|.:||:.|                     ..||.|.......      |..||:.|:    |.
Human   563 RVSWSLPLVPGPLVGDGFLLRLWDGTRGQERRENVSSPQARTALLTGLTPGTHYQLDVQLYHCTL 627

  Fly   178 NAMVRRSARVYIPQCLEGKCSCQLAPTPPKVLAVAKMLSNETISINLSILASELLRKEQDSHLHE 242
            .......|.|.:|..         .|..|:.|. |:.||:..|         :|..|..:: |..
Human   628 LGPASPPAHVLLPPS---------GPPAPRHLH-AQALSDSEI---------QLTWKHPEA-LPG 672

  Fly   243 TLRTYKMQLKI--------------NEETNPSLPWGGVLKHLMTRVYKLSELNFRATPKGFEGVM 293
            .:..|.:::::              .|||:.      :::.|......|  ...||:.:|
Human   673 PISKYVVEVQVAGGAGDPLWIDVDRPEETST------IIRGLNASTRYL--FRMRASIQG----- 724

  Fly   294 KLGLGTQLKEKASL--SLQAVIIDPTGCEGPRSVTKVPVPA--NPVLLTEGDSVSNSIIVMSAML 354
             ||..:...|:::|  .|||        |||...::.....  ..::|....|||.:.:.:.|.|
Human   725 -LGDWSNTVEESTLGNGLQA--------EGPVQESRAAEEGLDQQLILAVVGSVSATCLTILAAL 780

  Fly   355 IAIILAGLIMLLLRRRRART----------------TAKLRKQEQIYIQTFATSAIEMEDNVNYV 403
            :.::.  :....|.|||..|                |..|.::.::..:..:...:|.|| :.:.
Human   781 LTLVC--IRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRPKLQPEPLSYPVLEWED-ITFE 842

  Fly   404 DKYVEKSQVLGLADIFEVPHSAIQIGRMLGEGAFGQVHEATAINLRRMRGTTI-VAVKQLKPNPK 467
            |                          ::|||.||||..|    :.:..|..: .|:|.||....
Human   843 D--------------------------LIGEGNFGQVIRA----MIKKDGLKMNAAIKMLKEYAS 877

  Fly   468 ADEVAEYLAEIEMLKGVGTHHNVVSFLGCCTIKPPYLMIMEYVNKGNLLSYLRTVRKEASKLRNR 532
            .::..::..|:|:|..:|.|.|:::.||.|..:....:.:||...||||.:||..|
Human   878 ENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSR--------- 933

  Fly   533 NANYTSCRPIMTRTNSTSSPKSQSVNYIELKASSQTIEMPQEDSTAHMNGIRQPHPSFAETTYTI 597
                                                              :.:..|:||.
Human   934 --------------------------------------------------VLETDPAFAR----- 943

  Fly   598 VEDEDAFEYILDNKELHNFALQIANGMRFLEEQEITHRDLAARNVLIDSNKTLKISDFGLSR-HG 661
               |......|.:::|..||...||||::|.|::..||||||||||:..|...||:|||||| ..
Human   944 ---EHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEE 1005

  Fly   662 IYTNTRTRKLPLRWLSIEAIRENVYSSKSDIWAYGVVLWEIGTLGASPYPTISNDELIPFLMAGN 726
            :|......:||:||::||::..:||::|||:|::||:||||.:||.:||..::..||...|..|.
Human  1006 VYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGY 1070

  Fly   727 RLERPEICTPQVYTIMLQCWLEEPEERPTFD----ALYKVLSPKTTYVDINSLSDDYVFPPISEN 787
            |:|:|..|..:||.:|.|||.:.|.|||.|.    .|.::|..:..||:: ||.:::.:..|...
Human  1071 RMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNM-SLFENFTYAGIDAT 1134

  Fly   788 RE 789
            .|
Human  1135 AE 1136

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3277	NP_608762.3	STYKc	426..763	CDD:214568	107/342 (31%)
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	107/338 (32%)
TIE1	NP_005415.1	ig	129..210	CDD:278476
		EGF_CA	227..256	CDD:238011
		EGF_2	315..344	CDD:285248
		ig	356..441	CDD:278476
		fn3	452..536	CDD:278470	19/96 (20%)
		fn3	548..632	CDD:278470	15/84 (18%)
		FN3	644..736	CDD:238020	22/116 (19%)
		PTKc_Tie1	836..1132	CDD:270671	115/394 (29%)
		TyrKc	839..1107	CDD:197581	107/364 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910