DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3277 and Kit

DIOPT Version :9

Sequence 1:	NP_608762.3	Gene:	CG3277 / 33543	FlyBaseID:	FBgn0031518	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_071600.1	Gene:	Kit / 64030	RGDID:	620568	Length:	978	Species:	Rattus norvegicus

Alignment Length:	901	Identity:	220/901 - (24%)
Similarity:	363/901 - (40%)	Gaps:	235/901 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 SLVRSSEKEPEQMESHRYV--TGLSEPIAMEPLTRMRLNPNPDGEIT------------------ 83
            :|||....:| |:.::..:  .|.|.|      |.::..|||...||
  Rat   132 ALVRCPLTDP-QVSNYSLIECDGKSLP------TDLKFVPNPKAGITIKNVKRAYHRLCIRCAAQ 189

  Fly    84 ---------ELTTNVTLYMEKIPRLQVRWQDN-LPQGTSYNVLVSAVNNSRCPDAPCSEYGIKEK 138
                     :.|..|...::.||.:.|....: |.:|.::.|:             |:   ||:.
  Rat   190 REGKWMRSDKFTLKVRAAIKAIPVVSVPETSHLLKEGDTFTVI-------------CT---IKDV 238

  Fly   139 NASAETHSVNLPVNPNLNVE-------SVDCNYMFGCQYQVIVETSNAMVRRSARVYIPQCLEGK 196
            :.|.::..:.|...|....:       ..|.||    :.|..:..|:|.|..|.   :..|....
  Rat   239 STSVDSMWIKLNPQPQSKAQVKRNSWHQGDFNY----ERQETLTISSARVNDSG---VFMCYANN 296

  Fly   197 C--SCQLAPT------------PPKVLAVAKMLSNETISINLSILASELLRKEQDSHLHETLRTY 247
            .  |..:..|            |.|...|. :...|.:.:.:...|......:|..:::.| .|.
  Rat   297 TFGSANVTTTLKVVEKGFINIFPVKNTTVF-VTDGENVDLVVEFEAYPKPEHQQWIYMNRT-PTN 359

  Fly   248 KMQLKINEETNPSLPWGGVLKHLMTRVYKLSELNFRATPKGFEGVMKLGLGTQLKEKASLS---- 308
            :.:..:..:...::.:...|:  :||:            ||.||    |..|.|...:.:|
  Rat   360 RGEDYVKSDNQSNIRYVNELR--LTRL------------KGTEG----GTYTFLVSNSDVSASVT 406

  Fly   309 ---------------------LQAV-------IIDPTGCEGPRSVTKVPVPANPVLLTEGDSVS- 344
                                 ||.|       .||...|.|......||||...|.: :..|||
  Rat   407 FDVYVNTKPEILTYDRLMNGRLQCVAAGFPEPTIDWYFCTGAEQRCTVPVPPVDVQI-QNASVSP 470

  Fly   345 -NSIIVMSA-----------------------------------------------MLIAII--- 358
             ..::|.|:                                               :||..:
  Rat   471 FGKLVVQSSIDSSVFRHNGTVECKASNAVGKSSAFFNFAFKGNSKEQIQPHTLFTPLLIGFVVTA 535

  Fly   359 -LAGLIMLLLRRRRARTTAKLRKQEQIY-IQTFATSAIEMEDNVNYVDKYVEKSQVLGLADIFEV 421
             |.|:|:::|        |....|:.:| :|   ...:|..:..|||  |::.:| |.....:|.
  Rat   536 GLMGIIVMVL--------AYKYLQKPMYEVQ---WKVVEEINGNNYV--YIDPTQ-LPYDHKWEF 586

  Fly   422 PHSAIQIGRMLGEGAFGQVHEATAINLRRMRGTTIVAVKQLKPNPKADEVAEYLAEIEMLKGVGT 486
            |.:.:..|:.||.||||:|.||||..|.:......||||.|||:....|....::|:::|..:|.
  Rat   587 PRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGN 651

  Fly   487 HHNVVSFLGCCTIKPPYLMIMEYVNKGNLLSYLRTVRKEASKLRNRNANYTSCRPIMTRTNSTSS 551
            |.|:|:.||.||:..|.|:|.||...|:||::||  ||..|.:.::..............:|..|
  Rat   652 HMNIVNLLGACTVGGPTLVITEYCCYGDLLNFLR--RKRDSFIFSKQEEQADAALYKNLLHSKES 714

  Fly   552 PKSQSVNYIELKASSQTIEMPQEDS--TAHMNGIRQPHPSFAE--TTYTIVEDEDAFEYILDNKE 612
            ....|..|:::|.....:...:.|.  :|.::       |:.|  .|..|:||:   |..||.::
  Rat   715 SCDSSNEYMDMKPGVSYVVPTKTDKRRSARID-------SYIERDVTPAIMEDD---ELALDLED 769

  Fly   613 LHNFALQIANGMRFLEEQEITHRDLAARNVLIDSNKTLKISDFGLSR----HGIYTNTRTRKLPL 673
            |.:|:.|:|.||.||..:...||||||||:|:...:..||.||||:|    ...|......:||:
  Rat   770 LLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIRNDSNYVVKGNARLPV 834

  Fly   674 RWLSIEAIRENVYSSKSDIWAYGVVLWEIGTLGASPYPTISND-ELIPFLMAGNRLERPEICTPQ 737
            :|::.|:|...||:.:||:|:||:.|||:.:||:||||.:..| :....:..|.|:..||.....
  Rat   835 KWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAA 899

  Fly   738 VYTIMLQCWLEEPEERPTFDALYKVL------SPKTTYVDINSLSDDYVFPPISEN 787
            :|.:|..||..:|.:||||..:.:::      |.|..|.::.:.:      |..||
  Rat   900 MYEVMKTCWDADPLKRPTFKQVVQLIEKQISDSSKHIYSNLANCN------PNPEN 949

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3277	NP_608762.3	STYKc	426..763	CDD:214568	120/345 (35%)
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	119/341 (35%)
Kit	NP_071600.1	ig	216..307	CDD:278476	20/113 (18%)
		IG_like	220..309	CDD:214653	20/111 (18%)
		Ig4_SCFR	313..413	CDD:143268	19/119 (16%)
		Ig	428..503	CDD:299845	17/75 (23%)
		PKc_like	555..929	CDD:304357	131/391 (34%)
		Pkinase_Tyr	591..925	CDD:285015	120/345 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810