DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3277 and RET

DIOPT Version :9

Sequence 1:	NP_608762.3	Gene:	CG3277 / 33543	FlyBaseID:	FBgn0031518	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_066124.1	Gene:	RET / 5979	HGNCID:	9967	Length:	1114	Species:	Homo sapiens

Alignment Length:	799	Identity:	199/799 - (24%)
Similarity:	331/799 - (41%)	Gaps:	229/799 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 LTTNVTLYMEKIPRLQVRWQDNLPQGTSYNVLVSAVNNSRCPDAPCSEYGIKEKNASAETHSVNL 149
            |..|:::...:..:|.|...|:..||....||:...|.|..|                  .|::|
Human   358 LNRNLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLP------------------VSLHL 404

  Fly   150 PVNPNLNVES-------------VDCNYMFGCQYQVIVETSNAMVRRSARVYIPQCLEGKCSCQL 201
            |...:|:|..             .:|....|...|..:.:|.|                .||
Human   405 PSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGA----------------NCS--- 450

  Fly   202 APTPPKVLAVAKMLSNETISINLSILASELLRKEQDSHLH--------ETLRTYKMQLKIN---- 254
                    .:..:.|.|..|..|.:..::.||:.:.:.||        :|.|..:.||.:.
Human   451 --------TLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGS 507

  Fly   255 ---EETNPSLPWGGVLKHL------------------------MTRVYKLSELNFRATPKGFEGV 292
               ||....|......:.|                        :||.:.....:.:..|.|...|
Human   508 YVAEEAGCPLSCAVSKRRLECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTKTCPDGHCDV 572

  Fly   293 MKLGLGTQLKEKASLSLQAVIIDPTGC-EG----------PRSV-----TKVPVPANPVLLTEGD 341
            ::              .|.:.|.|..| .|          ||.:     |....|.......|.:
Human   573 VE--------------TQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPE 623

  Fly   342 SVSNSI-------IVMSAMLIAIILAGLIMLL-------LRRRRARTTAKL--RKQEQIYIQTFA 390
            .:.:.:       ::.:|:|.:.|::.|:...       ...:...::|::  |:..|.:..:::
Human   624 DIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYS 688

  Fly   391 TSAI------EMEDNVNYVD--KYVEKSQVLGLADIFEVPHSAIQIGRMLGEGAFGQVHEATAIN 447
            :|..      .||:.|: ||  |.:|..:       :|.|...:.:|:.||||.||:|.:|||.:
Human   689 SSGARRPSLDSMENQVS-VDAFKILEDPK-------WEFPRKNLVLGKTLGEGEFGKVVKATAFH 745

  Fly   448 LRRMRGTTIVAVKQLKPNPKADEVAEYLAEIEMLKGVGTHHNVVSFLGCCTIKPPYLMIMEYVNK 512
            |:...|.|.||||.||.|....|:.:.|:|..:||.| .|.:|:...|.|:...|.|:|:||...
Human   746 LKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQV-NHPHVIKLYGACSQDGPLLLIVEYAKY 809

  Fly   513 GNLLSYLRTVRKEASKLRNRNANYTSCRPIMTRTNSTSSPKSQSVNYIELKASSQTIEMPQEDST 577
            |:|..:||..||.       ...|         ..|..|..|.|::
Human   810 GSLRGFLRESRKV-------GPGY---------LGSGGSRNSSSLD------------------- 839

  Fly   578 AHMNGIRQPHPSFAETTYTIVEDEDAFEYILDNKELHNFALQIANGMRFLEEQEITHRDLAARNV 642
                     ||           ||.|    |...:|.:||.||:.||::|.|.::.||||||||:
Human   840 ---------HP-----------DERA----LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNI 880

  Fly   643 LIDSNKTLKISDFGLSR----HGIYTNTRTRKLPLRWLSIEAIRENVYSSKSDIWAYGVVLWEIG 703
            |:...:.:|||||||||    ...|......::|::|::||::.:::|:::||:|::||:||||.
Human   881 LVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIV 945

  Fly   704 TLGASPYPTISNDELIPFLMAGNRLERPEICTPQVYTIMLQCWLEEPEERPTF----DALYKVLS 764
            |||.:|||.|..:.|...|..|:|:|||:.|:.::|.:|||||.:||::||.|    ..|.|::.
Human   946 TLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMV 1010

  Fly   765 PKTTYVDI--NSLSDDYVF 781
            .:..|:|:  ::.||..::
Human  1011 KRRDYLDLAASTPSDSLIY 1029

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3277	NP_608762.3	STYKc	426..763	CDD:214568	123/344 (36%)
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	122/340 (36%)
RET	NP_066124.1	Cadherin	172..261	CDD:278457
		PTKc_RET	723..1012	CDD:173631	123/348 (35%)
		Pkinase_Tyr	724..1005	CDD:285015	121/340 (36%)
		Inhibitors binding	805..807		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810