DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3277 and fgfr3

DIOPT Version :9

Sequence 1:	NP_608762.3	Gene:	CG3277 / 33543	FlyBaseID:	FBgn0031518	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	XP_021336328.1	Gene:	fgfr3 / 58129	ZFINID:	ZDB-GENE-000816-1	Length:	821	Species:	Danio rerio

Alignment Length:	682	Identity:	178/682 - (26%)
Similarity:	301/682 - (44%)	Gaps:	179/682 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 YQVIVETSNAMVRRSARVYIPQCLEGKCSCQLAPTPPKVLAVAKMLSNETISINLSILASELLRK 234
            |..:|:.....::.:.::.:           |..:|.:.:..|.:.:|:|:.:.
Zfish   238 YTCVVQNKYGTIKHTYQLDV-----------LERSPHRPILQAGLPANQTVVVG----------- 280

  Fly   235 EQDSHLHETLRTYKMQLKINEETNPSLPWGGVLKHLMTRVYKLSELN-FRATPKG--FEGVMK-L 295
             .|...|         .|:..:..|.:.|   |||:        |:| .:..|.|  :..|:| .
Zfish   281 -SDVEFH---------CKVYSDAQPHIQW---LKHI--------EVNGSQYGPNGAPYVNVLKTA 324

  Fly   296 GLGTQLKEKASLSLQAVIIDPTG---CEGPRSV---------TKVPVPANPVLLTEGDSVSNSII 348
            |:.|..||...|.|..|..:..|   |....|:         |.:|.    |.:...|..::.:|
Zfish   325 GINTTDKELEILYLTNVSFEDAGQYTCLAGNSIGYNHHSAWLTVLPA----VEMEREDDYADILI 385

  Fly   349 VMSAMLIAIILAGLIMLL---LRRRRARTTAKLRKQEQIYIQTFATSAIEMEDNVNYVDKYVEKS 410
            .:::.::.|:...:|:|.   :..::......::|..:..::...|.::|...::|.....|..:
Zfish   386 YVTSCVLFILTMVIIILCRMWINTQKTLPAPPVQKLSKFPLKRQVTVSLESNSSMNSNTPLVRIA 450

  Fly   411 QVLG-----LADI----------FEVPHSAIQIGRMLGEGAFGQV--HEATAINLRRMRGTTIVA 458
            ::..     |.::          :|...:.:.:|:.||||.||||  .||..|:..:......||
Zfish   451 RLSSSDGPMLPNVSELELPSDPKWEFTRTKLTLGKPLGEGCFGQVVMAEAIGIDKEKPNKPLTVA 515

  Fly   459 VKQLKPNPKADEVAEYLAEIEMLKGVGTHHNVVSFLGCCTIKPPYLMIMEYVNKGNLLSYLRTVR 523
            ||.||.:....::::.::|:||:|.:|.|.|:::.||.||...|..:::||.:||||..|||..|
Zfish   516 VKMLKDDGTDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVLVEYASKGNLREYLRARR 580

  Fly   524 KEASKLRNRNANYTSCRPIMTRTNSTSSPKSQSVNYIELKASSQTIEMPQEDSTAHMNGIRQPHP 588
                                          ...::|     |..|.::|.|..|.
Zfish   581 ------------------------------PPGMDY-----SFDTCKIPNETLTF---------- 600

  Fly   589 SFAETTYTIVEDEDAFEYILDNKELHNFALQIANGMRFLEEQEITHRDLAARNVLIDSNKTLKIS 653
                                  |:|.:.|.|:|.||.:|..::..||||||||||:..:..:||:
Zfish   601 ----------------------KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIA 643

  Fly   654 DFGLSR--HGI--YTNTRTRKLPLRWLSIEAIRENVYSSKSDIWAYGVVLWEIGTLGASPYPTIS 714
            ||||:|  |.|  |..|...:||::|::.||:.:.||:.:||:|:|||:||||.|||.||||.|.
Zfish   644 DFGLARDVHNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSYGVLLWEIFTLGGSPYPGIP 708

  Fly   715 NDELIPFLMAGNRLERPEICTPQVYTIMLQCWLEEPEERPTFDALY----KVLSPKTT--YVDIN 773
            .:||...|..|:|:::|..||.::|.||.:||...|.:||||..|.    :|||..:|  |:|::
Zfish   709 VEELFKLLKEGHRMDKPANCTHELYMIMRECWHAVPSQRPTFRQLVEDHDRVLSMTSTDEYLDLS 773

  Fly   774 -----------------SLSDDYVF--PPISE 786
                             |..||.||  .|:.|
Zfish   774 VPFEQYSPTCPDSNSTCSSGDDSVFAHDPLPE 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3277	NP_608762.3	STYKc	426..763	CDD:214568	119/346 (34%)
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	118/342 (35%)
fgfr3	XP_021336328.1	IGc2	67..121	CDD:197706
		Ig2_FGFR	173..257	CDD:143265	2/18 (11%)
		Ig3_FGFR-2	280..369	CDD:143266	25/120 (21%)
		PTKc_FGFR3	468..801	CDD:173652	131/399 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810