DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3277 and flt3

DIOPT Version :9

Sequence 1:	NP_608762.3	Gene:	CG3277 / 33543	FlyBaseID:	FBgn0031518	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	XP_001921760.3	Gene:	flt3 / 566708	ZFINID:	ZDB-GENE-050114-4	Length:	956	Species:	Danio rerio

Alignment Length:	1035	Identity:	226/1035 - (21%)
Similarity:	389/1035 - (37%)	Gaps:	364/1035 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHHSTKVPSRIVLILLLVL----VRNAVGQA-PRENATNPTLISLVRSSEKEPEQMESHRYVTGL 60
            ||...|     :|::||||    :::.:.:| ||.:....|    ||.:.:|.:.|.
Zfish     1 MHLGNK-----LLLVLLVLHWSSLKDGLTEAHPRCDTDGST----VRCTLEETDLMS-------- 48

  Fly    61 SEPIAMEPLTRMRLNPNPDGEITEL------------------TTNVTLYM----EKI------- 96
            |:||.::.         .:|::.|:                  .||.::::    ||:
Zfish    49 SDPIKLDV---------TEGQVVEIYSACEQNSSNERKCLCYQRTNSSIHLLQCIEKLGNEKYSV 104

  Fly    97 -------------------------------------------PRLQVRW---QDNLPQG----- 110
                                                       |:..:||   .|:..:|
Zfish   105 ICGNKTVTAVRATQRRPSVPVLKAILKAGSTNLAQLVCTSEGYPKPTLRWYGNSDDAAEGMTSSA 169

  Fly   111 -------TSYNVLVSAVNNSRCPDA-----PCSE---YGIKEKN------------------ASA 142
                   .||...:|...|.:|..:     .|:|   |.:.|||                  .:|
Zfish   170 CKTESTLISYYSYLSKNPNQKCCASNALGEECTEVYHYDLNEKNKQKSQNIIYLKSGQSLLLRAA 234

  Fly   143 ETHSVNLPVNPNLN---VESVDCNYMFGCQYQVIVETSNAMVRRSARVYIPQCLEGKCSCQLAPT 204
            ..|..|..:..:.|   ::.:.....:.....:.:|:.|   ...:.:|:       |:.. ..|
Zfish   235 RKHFKNPGIKWHFNNTVIKGITSLQFYDWTEHLFIESVN---MAHSGLYL-------CTSD-TET 288

  Fly   205 PPKVLAVAKMLSNETISI-----NLSILASE--------------------LLRKEQDSHLHETL 244
            |.......|:..::.|.|     |.||||..                    :...:......||.
Zfish   289 PRNCSTHVKVFEHDQIDILHLNENNSILAKNKTGFCFQSQVFSYPKARCYWITPNQTQIQCDETS 353

  Fly   245 RT---------------YKMQLKINE----------------------------ETNPSLPWGGV 266
            ::               |:|:|:..|                            ||...||
Zfish   354 QSNFTSTFKLCNTEPGQYQMKLETQEYSVMRNVSLCISDIPKITIRKNSSFTTCETESPLP---- 414

  Fly   267 LKHLMTRVYKLSELNFRATPKGFEGV---------------MKLGLGTQ-LKEKASLSLQAVI-- 313
                :|..:|......:..|:.::.:               .|:|...: ||.:..| ::..|
Zfish   415 ----VTVSWKTCPSLAKCDPEDWKEIAADQPEFTDSDQFCQKKIGFSRRHLKSEDHL-IKCCITN 474

  Fly   314 IDPTGCEGPRSVTKVPVPANPVLLTEGDSVSNSIIVMSAMLIAIILAGLIMLLLRRRRARTTAKL 378
            :..|||            :..:||   .:.|::..|:..:||.|:...:|.|::..|    ..|.
Zfish   475 VAGTGC------------SEKILL---QTKSHTYYVICFLLIVILFMIIIALIIFIR----VKKP 520

  Fly   379 RKQEQIYIQTFATSAIEM----EDNVNYVD----KYVEKSQVLGLADIFEVPHSAIQIGRMLGEG 435
            :.|.||.:       |:|    :::..|:|    ||..|         :|.|...:::|..||.|
Zfish   521 KYQSQIQM-------IQMIGPNDNDYIYIDFREFKYDLK---------WEFPRENLELGNELGSG 569

  Fly   436 AFGQVHEATAINLRRMRGTTIVAVKQLKPNPKADEVAEYLAEIEMLKGVGTHHNVVSFLGCCTIK 500
            |||.|.:|||..:.:...:..||||.||...:|.|....::|::||..:|.|.|:|:.||.||..
Zfish   570 AFGMVVQATAYGISKPGVSVQVAVKMLKEKHQAVEKEALMSELKMLTHIGHHENIVNLLGACTGS 634

  Fly   501 PPYLMIMEYVNKGNLLSYLRTVRKEASKL------------------RNRNANYTSCRPIMTRTN 547
            .|..:|.::...|:||:||::.|:...|.                  :|||::...........|
Zfish   635 GPIYLIFQFCCNGDLLNYLKSNRECFHKYLTDAFNKDRFRGLYHNFQQNRNSSEYVLSDNSQCLN 699

  Fly   548 STSSPKSQSVNYIELKASSQTIEMPQEDSTAHMNGIRQPHPSFAETTYTIVEDEDAFEYILDNKE 612
            .|.:.|.|......|.:||.:...|.|:                     ::|.||..:    .:|
Zfish   700 VTPASKEQENENDALLSSSISSGSPAEE---------------------MLECEDEHQ----EEE 739

  Fly   613 LH--------NFALQIANGMRFLEEQEITHRDLAARNVLIDSNKTLKISDFGLSR-------HGI 662
            ||        :|:.|:|.||:||..:...||||||||||:...:.:||:||||:|       :.:
Zfish   740 LHSLTYDDLLSFSFQVAKGMQFLSAKNCIHRDLAARNVLVTHGRQVKIADFGLARDIEHDSNYVV 804

  Fly   663 YTNTRTRKLPLRWLSIEAIRENVYSSKSDIWAYGVVLWEIGTLGASPYPTIS-NDELIPFLMAGN 726
            ..|.|   ||::|::.|:|.:.:|:.:|||||||::||||.:||.:|||.:: |:.....:.:|.
Zfish   805 RGNVR---LPVKWMAPESIFKGIYTMESDIWAYGILLWEIFSLGVTPYPGVTVNNTFYRMIESGY 866

  Fly   727 RLERPEICTPQVYTIMLQCWLEEPEERPTFDALYKVLSPKTT------YVDINSLSDDYV 780
            .||:|......||.:|.:||...|.:||.|..:...:..:..      |.::...|.|.:
Zfish   867 HLEQPYYAAESVYKVMCRCWALNPVDRPCFSKIVAFMEKELAALEERLYYNVGGYSHDEI 926

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3277	NP_608762.3	STYKc	426..763	CDD:214568	119/370 (32%)
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	118/366 (32%)
flt3	XP_001921760.3	IGc2	225..283	CDD:197706	7/67 (10%)
flt3	XP_001921760.3	PKc_like	522..907	CDD:328722	131/428 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910