DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3277 and pdgfrb

DIOPT Version :9

Sequence 1:	NP_608762.3	Gene:	CG3277 / 33543	FlyBaseID:	FBgn0031518	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	XP_021336701.1	Gene:	pdgfrb / 559529	ZFINID:	ZDB-GENE-030805-2	Length:	1072	Species:	Danio rerio

Alignment Length:	878	Identity:	222/878 - (25%)
Similarity:	361/878 - (41%)	Gaps:	221/878 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 ENATNPTL--------ISLVRSSEKEPEQMESHR-YVTGLSEPIAMEPLTRMRLNPNPDGEITEL 85
            |.:.||::        .:.:...|...|:.||.. ||..:..|.|::|...........||
Zfish   167 EGSYNPSVGYSAALDDRTYICKGELNGEEKESDLFYVFSILAPEALDPYINASKTVLKQGE---- 227

  Fly    86 TTNVTLYMEKIPRLQVRWQDNLPQGTSYNVLVSAVNNSRCPDAPCSEYGIKEKNASAETHSVNLP 150
            |.||...:..:..:...|                       |.|..:.|..|..... ..|:::.
Zfish   228 TLNVNCTVHGVELVFFSW-----------------------DFPNKDMGGIEPLTDV-LSSMSMR 268

  Fly   151 VNPNLNVESVDCNYMFGCQYQVIVETSNAMVRRSARVYIPQCLEGKCSCQLAPTPPKVLAVAKML 215
            ...|:...|:|.:..:.|.....|:..    |.||.:.|....:|..|.    |||....::..|
Zfish   269 SCLNITDVSLDRSGQYVCHVHEGVQDQ----RASASINITVLEKGFVSL----TPPLDRNISAQL 325

  Fly   216 -SNETISINL--------------SILASELLRKEQDSHLHETL---RT-------YKMQLKINE 255
             .|..:.:.:              :::....:|:|.::....||   ||       ||:.:: ||
Zfish   326 GENVELKVEIEAYPKPTVQWRKDGAVIRGHSMREEHETRFVSTLTLVRTRLQQMGLYKVTVQ-NE 389

  Fly   256 ETNPSLPWGGVLKHLMTRVY-----KLSELNFRATPKGFEGVMKLGLGTQLKEKASL-------- 307
            :         .||.::..:.     :::||:....|:....|..:..|.   .|.|:
Zfish   390 D---------ALKEMIFDLEVKVPPQITELSDHHLPEKKHAVTCVAEGV---PKPSIQWFSCDSM 442

  Fly   308 ---SLQAVIIDPTGCEGPRSVT-KVPVPAN----------------PVLLTEGDSVSN------- 345
               |.::.:..|. .|.|.||| :..|..|                |.|||.....||
Zfish   443 TRCSNRSAVWSPL-VEDPESVTIQTNVTYNSTRKIHQVLSQVTLVRPQLLTIRCEASNERGARAR 506

  Fly   346 -----------SIIVMSAML---IAIILAGLIMLLLRRRRARTTAKLRKQEQIYIQTFATSAIEM 396
                       .:.|::|:|   :.:|::.:|::.:.|::.|...:.:..|.:.:
Zfish   507 DIRLVNSTLFSQVAVLAAVLALVVIVIISIIILIAVWRKKPRYEIRWKVIESVSL---------- 561

  Fly   397 EDNVNYVDKYVEKSQV-LGLADIFEVPHSAIQIGRMLGEGAFGQVHEATAINLRRMRGTTIVAVK 460
             |...|:  ||:...: ..||  :|:|..::.:||.||.||||:|.||||..|...:..|.||||
Zfish   562 -DGHEYI--YVDPIHLPYDLA--WEMPRDSLVLGRTLGSGAFGRVVEATAYGLGISQSATKVAVK 621

  Fly   461 QLKPNPKADEVAEYLAEIEMLKGVGTHHNVVSFLGCCTIKPPYLMIMEYVNKGNLLSYLRTVRKE 525
            .||...:..|....::|::::..:|.|.|:|:.||.||.:.|..::.||...|:|:.||.  |.:
Zfish   622 MLKSTARRSETQALMSELKIMSHLGPHINIVNLLGACTKQGPLYLVTEYCRYGDLVDYLH--RNK 684

  Fly   526 ASKLRN---RN--ANYTS-CRPIMTRTNSTSS------------------PKSQSVNYIELKASS 566
            .|.|:|   :|  ||.|. |       |.:.|                  .|.:...|:.::..:
Zfish   685 HSFLQNFADKNHIANGTQIC-------NDSDSGKEYVSFGSECDGGYMDMTKDEQTEYVPMQELA 742

  Fly   567 QTI----------EMPQEDSTAHMNGIRQPHPSFAETTYTIVEDEDAFEYILDNKELHNFALQIA 621
            .||          |.|.:.......|.|..|.       .::.|.....|    .:|..|:.|:|
Zfish   743 DTIKYADIQPSPYESPYQQDIYQEQGHRVDHS-------LVISDSPVLSY----TDLVGFSYQVA 796

  Fly   622 NGMRFLEEQEITHRDLAARNVLIDSNKTLKISDFGLSRHGIYTNTRTRK----LPLRWLSIEAIR 682
            .||.||..:...|||||||||||...|..||.||||:|..::.|....|    |||:|::.|:|.
Zfish   797 QGMEFLASKNCVHRDLAARNVLICEGKLAKICDFGLARDIMHDNNYISKGSTFLPLKWMAPESIF 861

  Fly   683 ENVYSSKSDIWAYGVVLWEIGTLGASPYPTISNDELI-PFLMAGNRLERPEICTPQVYTIMLQCW 746
            .|:|::.||:|:||::||||.|||.:|||.:..:||. ..|..|.|:.:|...:.::|.:|.:||
Zfish   862 HNLYTTLSDVWSYGILLWEIFTLGGTPYPDLPMNELFYSALKRGYRMAKPSYASDEIYEVMRKCW 926

  Fly   747 LEEPEERPTFDALYKVLSPKTTYVDINSLSDDY 779
            .|:.|:||.|..|...:.        |.|||.|
Zfish   927 DEKYEKRPEFSFLVHTMG--------NMLSDAY 951

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3277	NP_608762.3	STYKc	426..763	CDD:214568	128/375 (34%)
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	127/371 (34%)
pdgfrb	XP_021336701.1	Ig	226..307	CDD:325142	20/112 (18%)
		Ig	309..403	CDD:325142	19/107 (18%)
		Ig_3	404..>437	CDD:316449	7/35 (20%)
		PKc_like	549..947	CDD:328722	138/440 (31%)
		Trypan_PARP	<980..1053	CDD:330686
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010