DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3277 and flt1

DIOPT Version :9

Sequence 1:	NP_608762.3	Gene:	CG3277 / 33543	FlyBaseID:	FBgn0031518	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001014829.3	Gene:	flt1 / 544667	ZFINID:	ZDB-GENE-050407-1	Length:	1272	Species:	Danio rerio

Alignment Length:	757	Identity:	191/757 - (25%)
Similarity:	321/757 - (42%)	Gaps:	164/757 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 PRLQVRWQDNLPQGTSYNVLVSAVNNSRCPDAPCSEY-GIKEKNASAETHSVNLPV--------- 151
            |::|..|....|:|.             |...|.|.: .:::|.....||:..|.:
Zfish   453 PQIQWLWHPCPPKGL-------------CEKPPPSSWTAVRKKTGVTSTHNPILTISHRQEVLEG 504

  Fly   152 -NPNLNVESVDCNYMFGCQYQVIVETSNAMVRRSARV--YIPQCLEGKCSCQLAPTPP-----KV 208
             |..:.|.:|....:.|. |:.:  |||.:.|....:  |:....||..: .|...|.     ::
Zfish   505 KNKTVGVLTVGEALVSGI-YRCV--TSNILGRDELDIPFYVTDVKEGLVA-SLVEEPREGGDLRL 565

  Fly   209 LAVA-----------KMLSNETISINLSILASELLRKEQDSHLHETLR--------TYKMQ---- 250
            |.:|           ::.|..|:....|.|..||...:....||..|:        ||:..
Zfish   566 LCIANRHLYSDLSWSRITSQITVWDEASGLDGELTEGQFSHTLHFGLKNLTARDSGTYRCSATHL 630

  Fly   251 ------------------------------LKINEETNPSLPWGGVLKHLMT---RVYKLSELNF 282
                                          :.::.......|..||.:..:|   ...||.:::
Zfish   631 LTGEHIHLDTAVEVTVLQAPVLLGNLSDHTVNVSNSITLHCPARGVPQPHITWYKNQRKLQQVS- 694

  Fly   283 RATPKGFEGVMKLGLGTQLKEKASLSLQAVIIDPTG---CEGPRSVTKVPVPANPVLLTEGDSVS 344
                    |:|      ...|:.:|.:..:.::..|   |:.......|...|...:....:|:|
Zfish   695 --------GIM------LFPEEGTLHIDRITVEDQGFYTCQATNQRGSVESSAYIWVQNSSESLS 745

  Fly   345 NSIIVMSAMLIAIILAGLIMLLLRRRRARTTAKLRKQE--QIYIQTFATSAIEMEDNVNYVDKYV 407
            ..|..::...:...|..|::.||.|:.....:...|.|  .|.:.......:|..|.:.|
Zfish   746 LEIPTLACTCVVATLFWLLLTLLIRKLKHPNSDNGKAEYLPIILHPGEEPLVEHCDRLQY----- 805

  Fly   408 EKSQVLGLADIFEVPHSAIQIGRMLGEGAFGQVHEATAINLRRMRGTTIVAVKQLKPNPKADEVA 472
            :.::       :|.|...:::.:.||.||||:|.:|:|:.:......|.||||.||......|..
Zfish   806 DPAK-------WEFPRDRLKLEKPLGRGAFGRVMQASAVGIGNSASCTTVAVKMLKDGATPSEHK 863

  Fly   473 EYLAEIEMLKGVGTHHNVVSFLGCCTIK-PPYLMIMEYVNKGNLLSYLRTVRKEASKLRNRNAN- 535
            ..:.|:::|..:|.|.|||:.||.||.. .|.::|:||...|||.:||:: ::|...|...|..
Zfish   864 ALMTELKILNHIGHHINVVNLLGACTKSGGPLMVIVEYCQFGNLSAYLKS-KREVFLLNRVNKEE 927

  Fly   536 ----YTSCRPIMTRTNSTSSPKSQSVNYIELKASSQTIEMPQEDSTAHMNGIRQPHPSFAETTYT 596
                ...|:..:|..:|..|..|...       |.:..|:.:|||.. ::.:..|         .
Zfish   928 EGVMKEGCKGRLTSVSSRQSNASSGF-------SEERGEISEEDSDC-LSELSDP---------L 975

  Fly   597 IVEDEDAFEYILDNKELHNFALQIANGMRFLEEQEITHRDLAARNVLIDSNKTLKISDFGLSR-- 659
            ::||            |.:::.|:|.||.||..::..||||||||:|:.:|..:||.||||:|
Zfish   976 LLED------------LISYSFQVARGMEFLASRKCIHRDLAARNILLSNNNVVKICDFGLARDL 1028

  Fly   660 --HGIYTNTRTRKLPLRWLSIEAIRENVYSSKSDIWAYGVVLWEIGTLGASPYPTISND-ELIPF 721
              ...|......:|||:|::.|:|.:.|::::||:|:|||:||||.:|||||||.::.| |....
Zfish  1029 YKDPDYVRNGDARLPLKWMAPESIFDKVFTTQSDVWSYGVLLWEIFSLGASPYPGLNMDEEFCRR 1093

  Fly   722 LMAGNRLERPEICTPQVYTIMLQCWLEEPEERPTFDALYKVL 763
            |..|.|:..|:..||::|:||..||...||:||:|..|.::|
Zfish  1094 LKHGTRMCSPQYSTPEIYSIMCACWENNPEDRPSFTTLVEIL 1135

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3277	NP_608762.3	STYKc	426..763	CDD:214568	121/347 (35%)
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	121/343 (35%)
flt1	NP_001014829.3	Ig	238..321	CDD:386229
		Ig_VEGFR-1	345..416	CDD:143326
		Ig_3	426..529	CDD:372822	18/91 (20%)
		IG	558..646	CDD:214652	13/87 (15%)
		I-set	650..733	CDD:369462	13/97 (13%)
		PTKc_VEGFR	809..1138	CDD:270647	124/364 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810