DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3277 and Flt1

DIOPT Version :9

Sequence 1:	NP_608762.3	Gene:	CG3277 / 33543	FlyBaseID:	FBgn0031518	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_062179.2	Gene:	Flt1 / 54251	RGDID:	2621	Length:	1336	Species:	Rattus norvegicus

Alignment Length:	823	Identity:	205/823 - (24%)
Similarity:	358/823 - (43%)	Gaps:	213/823 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 TNPTLISLVRSSEKEP-------------EQMESHRYVTGLSE--PIAMEPLTRMRLNPNPDGEI 82
            ||.|:.:||.:..:.|             .:.:...|||.:..  .:::|.:.       .:||.
  Rat   515 TNKTVSTLVVADSRTPGIYSCKAFNKIGTVERDIRFYVTDVPNGFHVSLEKIP-------TEGED 572

  Fly    83 TELTTNVTLYMEKIPRLQVRWQDNLPQGTSYNVLVSAVNNSRCPDAPCSEYGI-KEKNASAETHS 146
            .:|:..|:.::.:    .:.|           :|:..|||.      ...:.| |:|.|:.:.:|
  Rat   573 LKLSCVVSKFLYR----DITW-----------ILLRTVNNR------TMHHSISKQKMATTQDYS 616

  Fly   147 VNLPVNPNLNVESVDCNYMFGCQYQVIVETSNAMVRRSARVYIPQCLEGKCSCQLAPTPPKVLAV 211
            :.|    ||.:::|.            :|.|.....|:..:|               |..::|..
  Rat   617 ITL----NLVIKNVS------------LEDSGTYACRARNIY---------------TGEEILRK 650

  Fly   212 AKMLSNETISINLSILASELLRKEQDSHLHETLRTYKMQLKINEETN----------PSLPWGGV 266
            .::|..:        |.:.||.:....|          ::.|:..|.          |.:.|
  Rat   651 TEVLVRD--------LEAPLLLQNLSDH----------EVSISGSTTLDCQARGVPAPQITW--- 694

  Fly   267 LKHLMTRVYKLSELNFRATPKGFEGVMKLGLGTQLKEKASLSLQAVIIDPTGCEGPRSVTKVPVP 331
                ....:|:.:          |..:.||.|     .::|.::.|..:..|....|:..:..|.
  Rat   695 ----FKNNHKIQQ----------EPGIILGPG-----NSTLFIERVTEEDEGVYRCRATNQKGVV 740

  Fly   332 ANPVLLT---EGDSVSNSIIVMSAMLIAIILAGLIMLLLRRRRARTTAKLRKQEQIYIQTFATSA 393
            .:...||   ..|..:..:|.::...:|..|..|::.|..|:..|::::::..   |:      :
  Rat   741 ESSAYLTVQGTSDKSNLELITLTCTCVAATLFWLLLTLFIRKLKRSSSEVKTD---YL------S 796

  Fly   394 IEMEDNVNYVDKYVEKSQVLGLADIFEVPHSAIQIGRMLGEGAFGQVHEATAINLRRMRGTTIVA 458
            |.|:.:...:|:..|:...  .|..:|.....:::|:.||.||||:|.:|:|..:::......||
  Rat   797 IIMDPDEVPLDEQCERLPY--DASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVA 859

  Fly   459 VKQLKPNPKADEVAEYLAEIEMLKGVGTHHNVVSFLGCCTIK-PPYLMIMEYVNKGNLLSYLRTV 522
            ||.||....|.|....:.|:::|..:|.|.|||:.||.||.: .|.::|:||...|||.:||::.
  Rat   860 VKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSK 924

  Fly   523 R------KEASKLRNRNANYTSCRPIMTRTNSTSSPKSQSVNYIELKASSQTIEMPQEDSTAH-- 579
            |      |:|:                    ....||.:     :|:...:..:.|:.||.:.
  Rat   925 RDFFCLNKDAA--------------------LHMEPKKE-----KLEPDLEQDQKPRLDSVSSSE 964

  Fly   580 ---MNGIRQPHPSFAETTYTIVEDEDAFEYI----LDNKELHNFALQIANGMRFLEEQEITHRDL 637
               .:|.::      :.:.:.||..:.:..|    |..::|.:::.|:|.||.||..::..||||
  Rat   965 SFTSSGFQE------DKSVSDVEGGEDYSEISKQPLTMEDLISYSFQVARGMEFLSSRKCIHRDL 1023

  Fly   638 AARNVLIDSNKTLKISDFGLSRHGIYTN--------TRTRKLPLRWLSIEAIRENVYSSKSDIWA 694
            ||||:|:..|..:||.||||:| .||.|        ||   |||:|::.|:|.:.|||:|||:|:
  Rat  1024 AARNILLSENNVVKICDFGLAR-DIYKNPDYVRRGDTR---LPLKWMAPESIFDKVYSTKSDVWS 1084

  Fly   695 YGVVLWEIGTLGASPYPTISNDE-LIPFLMAGNRLERPEICTPQVYTIMLQCWLEEPEERPTFDA 758
            |||:||||.:||.||||.:..|| ....|..|.|:..||..||::|.|||.||.::|:|||.|..
  Rat  1085 YGVLLWEIFSLGGSPYPGVQMDEDFCSRLKEGMRMRTPEYATPEIYQIMLDCWHKDPKERPRFAE 1149

  Fly   759 LYK---------VLSPKTTYVDINSL-----SDDYVFPPISEN 787
            |.:         |......|:.:|::     ...|..|..||:
  Rat  1150 LVEKLGDLLQANVQQDGKDYIPLNAILTRNSGFTYSVPTFSED 1192

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3277	NP_608762.3	STYKc	426..763	CDD:214568	128/370 (35%)
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	127/366 (35%)
Flt1	NP_062179.2	IG_like	143..219	CDD:214653
		IG_like	237..328	CDD:214653
		Ig	245..327	CDD:299845
		Ig	353..424	CDD:299845
		IG_like	439..552	CDD:214653	6/36 (17%)
		Ig	451..549	CDD:143165	6/33 (18%)
		IG	568..640	CDD:214652	21/108 (19%)
		IGc2	569..640	CDD:197706	21/107 (20%)
		I-set	661..748	CDD:254352	18/118 (15%)
		IGc2	676..738	CDD:197706	12/83 (14%)
		PKc_like	819..1157	CDD:304357	129/372 (35%)
		Pkinase_Tyr	827..1154	CDD:285015	128/361 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810