DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3277 and FGFRL1

DIOPT Version :9

Sequence 1:	NP_608762.3	Gene:	CG3277 / 33543	FlyBaseID:	FBgn0031518	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	XP_024309860.1	Gene:	FGFRL1 / 53834	HGNCID:	3693	Length:	527	Species:	Homo sapiens

Alignment Length:	472	Identity:	85/472 - (18%)
Similarity:	147/472 - (31%)	Gaps:	170/472 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 IVLILLLVL-VRNAVGQAPRENATNPTLISLV----------RSSEKEPEQMESH---RYVTGLS 61
            |.:|.:||: |.:..|||  |...:|.|:.|:          .::.:.|.:|...   |.|..|.
Human     5 ITMINVLVIPVTSRSGQA--EMTPSPLLLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQVARLG 67

  Fly    62 EPIAME-PLTRMRLNPNPDGEITELTTNVTLYMEKIPRLQVRWQ--DNLPQG------------- 110
            ..:.:: |:..   :|.|          :|::.:....:...|.  ..||||
Human    68 RTVRLQCPVEG---DPPP----------LTMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGV 119

  Fly   111 -------------TSYNVLV----SAVNNSRCPDAPCSEYGIKEKNASAE-------------TH 145
                         .:|.::|    |....|..||   |..|.:|..||.:             ..
Human   120 YVCKATNGFGSLSVNYTLVVLDDISPGKESLGPD---SSSGGQEDPASQQWARPRFTQPSKMRRR 181

  Fly   146 SVNLPVNPNLNVESV-------DCNYMFGCQYQVIVETSNAMVRRSARVYIPQCLE--------- 194
            .:..||..::.::.|       |..:|         :...|:.|       |:..|
Human   182 VIARPVGSSVRLKCVASGHPRPDITWM---------KDDQALTR-------PEAAEPRKKKWTLS 230

  Fly   195 ---------GKCSCQLAPTPPKVLAVAKMLSNETISINLSILASELLRKEQDSHLHETL------ 244
                     ||.:|:              :||...:||.:.....:.|......|..|.
Human   231 LKNLRPEDSGKYTCR--------------VSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTV 281

  Fly   245 ---RTYKMQLKINEETNPSLPWGGVLKHLMTRVYKLSELNFRAT-PKGFEGVMKLGLGTQLKEKA 305
               .|...|.|:..:..|.:.|       :.||...:|....:| ..|.:..:.|..|.......
Human   282 DFGGTTSFQCKVRSDVKPVIQW-------LKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPD 339

  Fly   306 SLSLQAVII-----DPTG---CEGPRS---------VTKVPVPANPVLLTEGDSVSNSI---IVM 350
            ...|..::|     |..|   |.|..:         :|.:|.|..|.......|.:.|:   :|:
Human   340 GSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGPPVASSSSATSLPWPVVI 404

  Fly   351 SAMLIAIILAGLIMLLL 367
            .....|:.:.|.::|.|
Human   405 GIPAGAVFILGTLLLWL 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3277	NP_608762.3	STYKc	426..763	CDD:214568
CG3277	NP_608762.3	PTKc	430..763	CDD:270623
FGFRL1	XP_024309860.1	I-set	56..139	CDD:254352	13/95 (14%)
		Ig2_FGFRL1-like	180..261	CDD:143264	16/110 (15%)
		Ig	284..378	CDD:325142	18/100 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900