DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3277 and PDGFRB

DIOPT Version :9

Sequence 1:	NP_608762.3	Gene:	CG3277 / 33543	FlyBaseID:	FBgn0031518	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_002600.1	Gene:	PDGFRB / 5159	HGNCID:	8804	Length:	1106	Species:	Homo sapiens

Alignment Length:	764	Identity:	199/764 - (26%)
Similarity:	324/764 - (42%)	Gaps:	172/764 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 EITELTTNVTLYM--EKIPRLQVRW-QDNLPQGTS---------YNV----LVSAVNNSRCPDAP 129
            :..||..:.||.:  |..|...|.| :||...|.|         .||    .||.:...|...|.
Human   326 QFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAE 390

  Fly   130 CSEYGIKEKNASAETH-----SVNLPV--------NPNLNVESVDCNYMFGCQYQVIVETSNAMV 181
            ...|.::..:..||..     .:|:||        :|:...::|.|......|..:|......:.
Human   391 AGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLK 455

  Fly   182 RRSARVYIPQCLEGKCSCQLAPTPPKVLAVAKMLSNETISINLSILASELLRKEQDSHLHETLRT 246
            |              |..:|.||         :|.|.:               |::|.| ||..|
Human   456 R--------------CPRELPPT---------LLGNSS---------------EEESQL-ETNVT 481

  Fly   247 YKMQLKINEETNPSLPWGGVLKHLMTRVYKLSELNFRATPKGFEGVMKLGLGTQLKEKASLSLQA 311
            |               |....:..:....:|..::           ..|.:...|:.......|.
Human   482 Y---------------WEEEQEFEVVSTLRLQHVD-----------RPLSVRCTLRNAVGQDTQE 520

  Fly   312 VIIDPTGCEGPRSVTKVPVPANPVLLTEGDSVSNSIIVMSAMLIAIIL---AGLIMLLLRRRRAR 373
            ||:.|                        .|:...::|:||:|..::|   :.:|:::|.:::.|
Human   521 VIVVP------------------------HSLPFKVVVISAILALVVLTIISLIILIMLWQKKPR 561

  Fly   374 TTAKLRKQEQIYIQTFATSAIEMEDNVNYVDKYVEKSQVLGLADIFEVPHSAIQIGRMLGEGAFG 438
            ...:.:..|.:           ..|...|:  ||:..| |.....:|:|...:.:||.||.||||
Human   562 YEIRWKVIESV-----------SSDGHEYI--YVDPMQ-LPYDSTWELPRDQLVLGRTLGSGAFG 612

  Fly   439 QVHEATAINLRRMRGTTIVAVKQLKPNPKADEVAEYLAEIEMLKGVGTHHNVVSFLGCCTIKPPY 503
            ||.||||..|...:.|..||||.||...::.|....::|::::..:|.|.|||:.||.||...|.
Human   613 QVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPI 677

  Fly   504 LMIMEYVNKGNLLSYLRT-----VRKEASKLRNRNAN-YTSCRPI-------MTRTNSTSS---- 551
            .:|.||...|:|:.||..     ::..:.|.|..:|. |::..|:       ::.|..:..
Human   678 YIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMD 742

  Fly   552 -PKSQSVNYIELKASSQTIEMPQEDSTAHMNGIRQPHPSFAETT--YTIVEDEDAFEYILDNKEL 613
             .|.:||:|:.:......::....:|:.:|.......||..|.|  .|::.:.....|:    :|
Human   743 MSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYM----DL 803

  Fly   614 HNFALQIANGMRFLEEQEITHRDLAARNVLIDSNKTLKISDFGLS----RHGIYTNTRTRKLPLR 674
            ..|:.|:||||.||..:...|||||||||||...|.:||.||||:    |...|.:..:..|||:
Human   804 VGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLK 868

  Fly   675 WLSIEAIRENVYSSKSDIWAYGVVLWEIGTLGASPYPTI-SNDELIPFLMAGNRLERPEICTPQV 738
            |::.|:|..::|::.||:|::|::||||.|||.:|||.: .|::....:..|.|:.:|...:.::
Human   869 WMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEI 933

  Fly   739 YTIMLQCWLEEPEERPTFDALYKVL--------SPKTTYVDINSLSDDY 779
            |.||.:||.|:.|.||.|..|..:|        ..|...||...|..|:
Human   934 YEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDH 982

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3277	NP_608762.3	STYKc	426..763	CDD:214568	124/361 (34%)
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	123/357 (34%)
PDGFRB	NP_002600.1	ig	37..114	CDD:278476
		IG	40..110	CDD:214652
		IG_like	222..310	CDD:214653
		Ig1_PDGFR-alphabeta	228..312	CDD:143269
		Ig4_PDGFR-alpha	314..415	CDD:143267	21/88 (24%)
		Ig	425..523	CDD:299845	25/162 (15%)
		PTKc_PDGFR_beta	562..953	CDD:133238	132/408 (32%)
		Pkinase_Tyr	600..953	CDD:285015	123/356 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1019..1106
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910