DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3277 and drl

DIOPT Version :9

Sequence 1:	NP_608762.3	Gene:	CG3277 / 33543	FlyBaseID:	FBgn0031518	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001260566.1	Gene:	drl / 44355	FlyBaseID:	FBgn0015380	Length:	645	Species:	Drosophila melanogaster

Alignment Length:	712	Identity:	147/712 - (20%)
Similarity:	261/712 - (36%)	Gaps:	199/712 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 YGIKEKNASAETHSVNLPVNPNLNVESVDCNYM----FGCQYQVIVETSNAMVRRSARVYIPQCL 193
            |.::|  .:...:::|..|....|:..|...:.    ....|.:.:.||:..|       :|:.:
  Fly    42 YYVRE--GAINDYALNFAVPVPANISDVTFTWQSLVDHPLPYSINIATSDTEV-------LPRPI 97

  Fly   194 EGKCSCQLAPTPPKVLAVAKMLSNE-----TISINLSILASE---------------LLRKEQDS 238
            .........|..|:...:|...|..     |::||:.::...               .||:||||
  Fly    98 LNISRIGDVPVEPQTWGIALKCSGTRNAEVTVTINVEVILDRATNNNTNLIFKRKKICLREEQDS 162

  Fly   239 HLHETLRTYKMQLKINEETNPSLPWGGVL-------KHLMTRVYKLSELNFRATP--------KG 288
             .||......:.|.......    .||.:       :|::...::..|   :..|        :|
  Fly   163 -AHEEYDDDDLDLLQTARKG----HGGDIHYVDRNDEHVVANGHQAPE---KQRPVVTESPVGRG 219

  Fly   289 FEGVMKLGLGTQLKEKASLSLQAVIIDPTGCEGPRSVTKVPVPANPVLLTEGDSVSNSIIVMSAM 353
            ..|..|......|:|..                      ||..:..|.|..|..:  :::::|.:
  Fly   220 NSGGSKRDFDPMLRENL----------------------VPPASGLVTLIVGGIL--ALVLVSTL 260

  Fly   354 LIAIILA----------GLIMLLLRRRRARTTAKLRKQEQIYI------QTFATSAIEMEDNVNY 402
            ::....|          |:.::.....:...|........||:      .|:||......:..:.
  Fly   261 ILIAYCAKGPSKRHPSNGVHLIKTSSFQRLPTISSTAHNSIYVCPSTITPTYATLTRPFREYEHE 325

  Fly   403 VDKYVEKSQVLGLADIFEVPHSAIQIGRMLGEGAFGQVHEATAINLRRMRGTTIVA-VKQLKPNP 466
            .:::..:.|.|      .|....:::..::.||.||:::..|..:.:.:...|:.. ..||:.|
  Fly   326 PEEFNRRLQEL------TVQKCRVRLSCLVQEGNFGRIYRGTYNDCQEVLVKTVAQHASQLQVN- 383

  Fly   467 KADEVAEYLAEIEMLKGVGTHHNVVSFLGCCTIKPPYLMIMEYVNKGNLLSYLRTVRKEASKLRN 531
                   .|.:..|:....:|.||:|.||        :.|.:|.....|.:...:||...|.|::
  Fly   384 -------LLLQESMMLYEASHPNVLSVLG--------ISIEDYATPFVLYAATGSVRNLKSFLQD 433

  Fly   532 RNANYTSCRPIMTRTNSTSSPKSQSVNYIELKASSQTIEMPQEDSTAHMNGIRQPHPSFAETTYT 596
                                                                    ||:|.:..|
  Fly   434 --------------------------------------------------------PSYARSVTT 442

  Fly   597 IVEDEDAFEYILDNKELHNFALQIANGMRFLEEQEITHRDLAARNVLIDSNKTLKISDFGLSRH- 660
            |       :.:|       ...|:|..|..|....:.|:|:||||.:||....:|::|..|||.
  Fly   443 I-------QTVL-------MGSQLAMAMEHLHNHGVIHKDIAARNCVIDDQLRVKLTDSALSRDL 493

  Fly   661 --GIYTNTRTRKL-PLRWLSIEAIRENVYSSKSDIWAYGVVLWEIGTLGASPYPTISNDELIPFL 722
              |.|.:....:. |::|||:||::::.|:..||:|::||::||:.|||..||..|...|:..:|
  Fly   494 FPGDYNSLGDGEYRPIKWLSLEALQKSHYNEGSDVWSFGVLMWEMCTLGKLPYAEIDPYEMEHYL 558

  Fly   723 MAGNRLERPEICTPQVYTIMLQCWLEEPEERPTFDALYKVLSPKTTYVDINSLSDDYVFPPI 784
            ..|.||.:|..|..:::|||..||...|.|||:|..|...||...|.:      ..||.|.:
  Fly   559 KDGYRLAQPFNCPDELFTIMAYCWASMPAERPSFSQLQICLSEFHTQI------TRYVXPAV 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3277	NP_608762.3	STYKc	426..763	CDD:214568	87/341 (26%)
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	87/337 (26%)
drl	NP_001260566.1	WIF	21..157	CDD:128745	18/123 (15%)
		PTK_Ryk	336..606	CDD:270639	92/361 (25%)
		Pkinase_Tyr	343..599	CDD:285015	87/341 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455316
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030