DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3277 and btl

DIOPT Version :9

Sequence 1:	NP_608762.3	Gene:	CG3277 / 33543	FlyBaseID:	FBgn0031518	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster

Alignment Length:	882	Identity:	221/882 - (25%)
Similarity:	337/882 - (38%)	Gaps:	285/882 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 NATN-PTLISLVRSSEKEPEQMESHRYVTGLSEP-------IAMEP------LTRMRLNP----- 76
            ||.| ..|:..:|...:.|  ::..|.:|.:.||       :.||.      :...::..
  Fly   280 NADNIDDLLQRLREQSQLP--VDVTRLITRMDEPQVLRLGNVLMEDGGWYICIAENQVGRTVAAS 342

  Fly    77 -----NPDGEITELTTNVTLYMEKIPRLQVRWQDNLPQGTSYNVLVSAVNNSRCPDAPCSEYGIK 136
                 :|....|..||..|.....||.... .:||     ..:|...|...|.....|.....:|
  Fly   343 YVDLYSPSDTTTVRTTTTTTVASPIPTAST-GEDN-----DDDVENPAAEASGGVGPPVFRKELK 401

  Fly   137 EKNASAETHSVNL-----------------PVNPNLNV-------------ESVD--------CN 163
            ....|...::|||                 |:|..|.|             .|.|        ||
  Fly   402 RLQHSLSGNTVNLACPVYGKANITWTKDKKPLNRELGVYVQKNWTLRFVEATSEDSGLYNCKVCN 466

  Fly   164 YMFGC-QYQVIVETSNAMVRRSARVYIPQCLEGKCSCQLAPTPPKVLAVAKMLSNETISINLSIL 227
             .:|| |:...|:. |...|.:..:.:||                         |:|:.:|.|:
  Fly   467 -AWGCIQFDFSVQI-NDRTRSAPIIVVPQ-------------------------NQTVKVNGSL- 503

  Fly   228 ASELLRKEQDSHLHETLRTYKMQLKINEETNPSLPWGGVLKHLMTRVYKLSELNFRATPKGFEGV 292
               :::....|.||.|:...::.||     |.||..   ||.:     ::..|||..|
  Fly   504 ---VMKCTVYSDLHPTVSWKRVVLK-----NASLDG---LKSV-----EIQNLNFTVT------- 545

  Fly   293 MKLGLGTQLKEKASLSLQAVIIDPTG---CEGP----RSVTKV------PVP---------ANPV 335
                     .:...|:|:.|..|..|   |...    ||.:.|      |:|         |:|:
  Fly   546 ---------NDSVVLTLRNVTFDQEGWYTCLASSGLGRSNSSVYLRVVSPLPPLEIYALLHAHPL 601

  Fly   336 LLTEGDSVSNSIIVMSAMLIAIILAG--LIMLLLRRRRARTTAKLR--------KQEQIY----- 385
            ..|          :.:..::|:.|.|  .|..:|||.|.....|||        |:..||
  Fly   602 GFT----------LAAITIVALFLLGSAFITFMLRRLRREKLLKLRIETVHQWTKKVIIYRPGGE 656

  Fly   386 -----------------------IQTFATSAIEMEDNVNYVDKYVEKSQVLGLADIFEVPHSAIQ 427
                                   :.|..|...:.....|..:..::.:        :|:|...:.
  Fly   657 EGSGCSSGDLQMPVIRIEKQRTTVSTTGTGGTDPAQGFNEYEFPLDSN--------WEIPRQQLS 713

  Fly   428 IGRMLGEGAFGQVHEATAINLRR--MRGTTIVAVKQLKPNPKADEVAEYLAEIEMLKGVGTHHNV 490
            :|.:|||||||:|..|.|..|.|  ....||||||.:|......::|..:.|:|::|.:|.|.|:
  Fly   714 LGSILGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINI 778

  Fly   491 VSFLGCCTIKPPYLMIMEYVNKGNLLSYLRTVRKEASKLRNRNANYTSCRPIMTRTNSTSSPKSQ 555
            ::.||||:...|..:|:||...|||..:|:..|..|.:.|:.:..|...:|::
  Fly   779 INLLGCCSQGGPLWVIVEYAPHGNLKDFLKQNRPGAPQRRSDSDGYLDDKPLI------------ 831

  Fly   556 SVNYIELKASSQTIEMPQEDSTAHMNGIRQPHPSFAETTYTIVEDEDAFEYILDNKELHNFALQI 620
                                ||.|                            |..|||..||.||
  Fly   832 --------------------STQH----------------------------LGEKELTKFAFQI 848

  Fly   621 ANGMRFLEEQEITHRDLAARNVLIDSNKTLKISDFGLSRH----GIYTNTRTRKLPLRWLSIEAI 681
            |.||.:|..:...||||||||||:.....:||:||||:|.    ..|......:||::|::.|::
  Fly   849 ARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDIQDTEYYRKNTNGRLPIKWMAPESL 913

  Fly   682 RENVYSSKSDIWAYGVVLWEIGTLGASPYPTI-SNDELIPFLMAGNRLERPEICTPQVYTIMLQC 745
            :|..|.|:||:|:|||:||||.|.|..|||.| |.:||..:|:.|.|:|:|..|:..:|.:|.||
  Fly   914 QEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQC 978

  Fly   746 WLEEPEERPTFDALYKVL---------SPKTTYVDIN 773
            |..|...||||..|.:..         :|...|:|::
  Fly   979 WHFESCARPTFAELVESFDGILQQASSNPNDAYLDLS 1015

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3277	NP_608762.3	STYKc	426..763	CDD:214568	120/343 (35%)
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	119/339 (35%)
btl	NP_001014583.1	IG_like	149..232	CDD:214653
		IGc2	157..215	CDD:197706
		IG	247..336	CDD:214652	12/57 (21%)
		Ig	258..340	CDD:143165	12/61 (20%)
		I-set	394..479	CDD:254352	18/85 (21%)
		IGc2	408..469	CDD:197706	11/61 (18%)
		IG_like	492..583	CDD:214653	30/148 (20%)
		Ig	507..583	CDD:299845	24/104 (23%)
		PKc_like	700..1000	CDD:304357	122/367 (33%)
		TyrKc	712..996	CDD:197581	120/343 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455230
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	1	0.900	-	-		E1_KOG0200
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.840