DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG3277 and KIT

DIOPT Version :9

Sequence 1:NP_608762.3 Gene:CG3277 / 33543 FlyBaseID:FBgn0031518 Length:789 Species:Drosophila melanogaster
Sequence 2:NP_001372213.1 Gene:KIT / 3815 HGNCID:6342 Length:977 Species:Homo sapiens


Alignment Length:439 Identity:145/439 - (33%)
Similarity:232/439 - (52%) Gaps:35/439 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly   349 VMSAMLIA-IILAG---LIMLLLRRRRARTTAKLRKQEQIYIQTFATSAIEMEDNVNYVDKYVEK 409
            :.:.:||. :|:||   :|:::|       |.|..::....:|   ...:|..:..|||  |::.
Human   522 LFTPLLIGFVIVAGMMCIIVMIL-------TYKYLQKPMYEVQ---WKVVEEINGNNYV--YIDP 574

  Fly   410 SQVLGLADIFEVPHSAIQIGRMLGEGAFGQVHEATAINLRRMRGTTIVAVKQLKPNPKADEVAEY 474
            :| |.....:|.|.:.:..|:.||.||||:|.||||..|.:......||||.|||:....|....
Human   575 TQ-LPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREAL 638

  Fly   475 LAEIEMLKGVGTHHNVVSFLGCCTIKPPYLMIMEYVNKGNLLSYLRTVRKEASKLRNRNANYTSC 539
            ::|:::|..:|.|.|:|:.||.|||..|.|:|.||...|:||::||  ||..|.:.::..::...
Human   639 MSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLR--RKRDSFICSKQEDHAEA 701

  Fly   540 RPIMTRTNSTSSPKSQSVN-YIELKASSQTIEMPQEDSTAHMNGIRQPHPSFAETTYTIVEDEDA 603
            .......:|..|..|.|.| |:::|.....:...:.|.   ...:|.......:.|..|:||:  
Human   702 ALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADK---RRSVRIGSYIERDVTPAIMEDD-- 761

  Fly   604 FEYILDNKELHNFALQIANGMRFLEEQEITHRDLAARNVLIDSNKTLKISDFGLSR----HGIYT 664
             |..||.::|.:|:.|:|.||.||..:...||||||||:|:...:..||.||||:|    ...|.
Human   762 -ELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYV 825

  Fly   665 NTRTRKLPLRWLSIEAIRENVYSSKSDIWAYGVVLWEIGTLGASPYPTISND-ELIPFLMAGNRL 728
            .....:||::|::.|:|...||:.:||:|:||:.|||:.:||:||||.:..| :....:..|.|:
Human   826 VKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRM 890

  Fly   729 ERPEICTPQVYTIMLQCWLEEPEERPTF----DALYKVLSPKTTYVDIN 773
            ..||....::|.||..||..:|.:||||    ..:.|.:|..|.::..|
Human   891 LSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSN 939

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG3277NP_608762.3 STYKc 426..763 CDD:214568 123/346 (36%)
PTKc 430..763 CDD:270623 122/342 (36%)
KITNP_001372213.1 Ig strand A 212..215 CDD:409353
ig 216..306 CDD:395002
Ig strand B 229..239 CDD:409353
Ig strand C' 250..252 CDD:409353
Ig strand D 260..263 CDD:409353
Ig strand E 267..280 CDD:409353
Ig strand F 287..294 CDD:409353
Ig strand G 300..308 CDD:409353
IgI_4_SCFR 312..412 CDD:409446
Ig strand B 332..336 CDD:409446
Ig strand C 346..350 CDD:409446
Ig strand E 376..380 CDD:409446
Ig strand F 390..395 CDD:409446
Ig strand G 403..406 CDD:409446
Ig 427..503 CDD:409353
Ig strand C 438..442 CDD:409353
Ig strand E 471..479 CDD:409353
Ig strand F 489..494 CDD:409353
PTKc_Kit 554..929 CDD:270682 133/388 (34%)
Important for interaction with phosphotyrosine-binding proteins 569..571 2/3 (67%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0200
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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