Protein Alignment CG3277 and INSRR

DIOPT Version :10

• Sequence 1: NP_608762.3
• Gene: CG3277 / 33543
• FlyBaseID: FBgn0031518
• Length: 789
• Species: Drosophila melanogaster
• Sequence 2: NP_055030.1
• Gene: INSRR / 3645
• HGNCID: 6093
• Length: 1297
• Species: Homo sapiens
• Alignment Length: 749
• Identity: 183/749 - (24%)
• Similarity: 274/749 - (36%)
• Gaps: 250/749 - (33%)

  Fly    41 VRSSEKEPEQMES-HRYVTGLSEPIAMEPLTRMRLNPN-PDGEITELTTNVTLYMEKIPRLQVRW 103
            |.|..|.|::... ||...|        ||   ||..| .|.||.|         :|:|| :...
Human   730 VTSINKSPQRDSGRHRRAAG--------PL---RLGGNSSDFEIQE---------DKVPR-ERAV 773

  Fly   104 QDNLPQGTSYNVLVSAVNNSRCPDAPCSEYGIKEKNASAETHSVNLPVNPNLNVESVDCNYMFGC 168
            ...|...|.|.:.:.|.|::                    .|:|                   ||
Human   774 LSGLRHFTEYRIDIHACNHA--------------------AHTV-------------------GC 799

  Fly   169 QYQVIVETSNAMVRRSARVYIPQCLEGKCSCQ-----------LAPTPPKVLAVAKMLSNETISI 222
            .....| .:..|..|.|     ..:.||.:.:           |.|..|..|.:...:....:..
Human   800 SAATFV-FARTMPHREA-----DGIPGKVAWEASSKNSVLLRWLEPPDPNGLILKYEIKYRRLGE 858

  Fly   223 NLSILASELLRKEQDSHLHETLRTYKMQLKINEETNPSLPWGGVLKHLMTRVYKLSELNFRATPK 287
            ..::|....||..:...:|..|                ||.|                |:.|..:
Human   859 EATVLCVSRLRYAKFGGVHLAL----------------LPPG----------------NYSARVR 891

  Fly   288 GFEGVMKLGLGTQLKEKASL--SLQAVIIDPTGCEGPRSVTKVPVPANPVLLTEGDSVSNSIIVM 350
                      .|.|....|.  |:...|:.|.  |.......|.:.|.||.||
Human   892 ----------ATSLAGNGSWTDSVAFYILGPE--EEDAGGLHVLLTATPVGLT------------ 932

  Fly   351 SAMLIAIILAGLIMLLLRRRRARTTAKLRKQEQIYIQTFATSAIEMEDNVNYVDKYVEKSQVLGL 415
                :.|:||.|.....::|.....|.:..      :.|:.|           |.||
Human   933 ----LLIVLAALGFFYGKKRNRTLYASVNP------EYFSAS-----------DMYV-------- 968

  Fly   416 ADIFEVPHSAIQIGRMLGEGAFGQVHEATAINLRRMRGTTIVAVKQLKPNPKADEVAEYLAEIEM 480
            .|.:|||...|.|.|.||:|:||.|:|..|..|.....:|.||:|.:.......|..|:|.|..:
Human   969 PDEWEVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPRECIEFLKEASV 1033

  Fly   481 LKGVGTHHNVVSFLGCCTIKPPYLMIMEYVNKGNLLSYLRTVRKEASKLRNRNANYTSCRPIMTR 545
            :|....|| ||..||..:...|.|:|||.:.:|:|.|:||::|.||.
Human  1034 MKAFKCHH-VVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAE------------------ 1079

  Fly   546 TNSTSSPKSQSVNYIELKASSQTIEMPQEDSTAHMNGIRQPHPSFAETTYTIVEDEDAFEYILDN 610
                                               |....|.|:..
Human  1080 -----------------------------------NNPGLPQPALG------------------- 1090

  Fly   611 KELHNFALQIANGMRFLEEQEITHRDLAARNVLIDSNKTLKISDFGLSRHGIYTNTRTRK----- 670
             |:...|.:||:||.:|...:..||||||||.::..:.|:||.|||::| .:|.....||
Human  1091 -EMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTR-DVYETDYYRKGGKGL 1153

  Fly   671 LPLRWLSIEAIRENVYSSKSDIWAYGVVLWEIGTLGASPYPTISNDELIPFLMAGNRLERPEICT 735
            ||:||::.|::::.::::.||:|::|||||||.||...||..:||::::.|:|.|..||..|.|.
Human  1154 LPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELEGCP 1218

  Fly   736 PQVYTIMLQCWLEEPEERPTF----DALYKVLSP 765
            .|:..:|.:||...|..||:|    |::.:.|.|
Human  1219 LQLQELMSRCWQPNPRLRPSFTHILDSIQEELRP 1252

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	103/341 (30%)
INSRR	NP_055030.1	Recep_L_domain	47..158	CDD:460032
		Furin-like	173..326	CDD:395614
		Recep_L_domain	346..461	CDD:460032
		FN3	<489..>640	CDD:442628
		FN3	605..>649	CDD:238020
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	666..687
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	732..758		11/36 (31%)
		FN3	819..908	CDD:238020	20/130 (15%)
		PTKc_InsR_like	972..1248	CDD:173625	108/350 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1267..1297