DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3277 and Ror

DIOPT Version :9

Sequence 1:	NP_608762.3	Gene:	CG3277 / 33543	FlyBaseID:	FBgn0031518	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_476962.1	Gene:	Ror / 34367	FlyBaseID:	FBgn0010407	Length:	685	Species:	Drosophila melanogaster

Alignment Length:	731	Identity:	176/731 - (24%)
Similarity:	281/731 - (38%)	Gaps:	206/731 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 YGIKEKNASAETH----------SVNLPVNPNLNVESVDCNYMFGCQYQVIVETSNAMVRRSARV 187
            ||.::.:.....:          :.::.|:|||.:.  |........|.||.|:.:  :..:.|:
  Fly    32 YGFQQSSGICHIYNGTICRDVLSNAHVFVSPNLTMN--DLEERLKAAYGVIKESKD--MNANCRM 92

  Fly   188 Y-IPQ-CLEGKCSCQLAPTPPKVLAVAKMLSNETISINLSILASELLRKEQDSHLHETLRTYKMQ 250
            | :|. |......|: .|....:|..|.:.:|.....|:||     .||...|...:.:..:|.:
  Fly    93 YALPSLCFSSMPICR-TPERTNLLYFANVATNAKQLKNVSI-----RRKRTKSKDIKNISIFKKK 151

  Fly   251 LKINEET--------NPSLPWGGVLKHLMTRVYKLSE---------LNFRATPKGFEGV------ 292
            ..|.|:.        .|.......||.:.....:|.|         :..|....|..||
  Fly   152 STIYEDVFSTDISSKYPPTRESENLKRICREECELLENELCQKEYAIAKRHPVIGMVGVEDCQKL 216

  Fly   293 ------MKLGL--------------GTQLKEKASLSLQA-----------------VIIDPTGCE 320
                  :.||:              |:..:..|::|...                 .:|....|.
  Fly   217 PQHKDCLSLGITIEVDKTENCYWEDGSTYRGVANVSASGKPCLRWSWLMKEISDFPELIGQNYCR 281

  Fly   321 GPRSVTKVP---VPANPVLLTE-------GDSVSNSIIVMSAMLIAIILAGLIMLLLRRRR---- 371
            .|.||...|   |.::...:.|       .|.:..:|:..:|.:|.|.:....::|.:||.
  Fly   282 NPGSVENSPWCFVDSSRERIIELCDIPKCADKIWIAIVGTTAAIILIFIIIFAIILFKRRTIMHY 346

  Fly   372 -ARTTAKLR---KQEQIYIQTFATSAIE--------MEDNVNYVDKYVEKSQVLGLADIFEVPHS 424
             .|....:.   ..:.||..:...:|.:        :.|:|....|.:|::.:|      .:.|.
  Fly   347 GMRNIHNINTPSADKNIYGNSQLNNAQDAGRGNLGNLSDHVALNSKLIERNTLL------RINHF 405

  Fly   425 AIQ---IGRMLGEGAFGQVHEATAINLRRMRGTTI-VAVKQLKPNPKADEVAEYLAEIEMLKGVG 485
            .:|   ....|||||||:|::.   .|.:...||| ||:|.||.|.......::..|||::..:
  Fly   406 TLQDVEFLEELGEGAFGKVYKG---QLLQPNKTTITVAIKALKENASVKTQQDFKREIELISDL- 466

  Fly   486 THHNVVSFLGCCTIKPPYLMIMEYVNKGNLLSYLRTVRKEASKLRNRNANYTSCRPIMTRTNSTS 550
            .|.|:|..||....|.||.|:.||:..|:|..:|                         .:||.:
  Fly   467 KHQNIVCILGVVLNKEPYCMLFEYMANGDLHEFL-------------------------ISNSPT 506

  Fly   551 SPKSQSVNYIELKASSQTIEMPQEDSTAHMNGIRQPHPSFAETTYTIVEDEDAFEYILDNKELHN 615
            ..||                                                     |...|...
  Fly   507 EGKS-----------------------------------------------------LSQLEFLQ 518

  Fly   616 FALQIANGMRFLEEQEITHRDLAARNVLIDSNKTLKISDFGLSRHGIYTNTRTR-----KLPLRW 675
            .||||:.||::|......||||||||.|::....:||||||||| .||::...|     .||:||
  Fly   519 IALQISEGMQYLSAHHYVHRDLAARNCLVNEGLVVKISDFGLSR-DIYSSDYYRVQSKSLLPVRW 582

  Fly   676 LSIEAIRENVYSSKSDIWAYGVVLWEIGTLGASPYPTISNDELIPFLMAGNRLERPEICTPQVYT 740
            :..|:|....::::||:|::|||||||.:.|..||...||.|:|..:.:...|..||.|...||:
  Fly   583 MPSESILYGKFTTESDVWSFGVVLWEIYSYGMQPYYGFSNQEVINLIRSRQLLSAPENCPTAVYS 647

  Fly   741 IMLQCWLEEPEERPTF 756
            :|::||.|:..:||||
  Fly   648 LMIECWHEQSVKRPTF 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3277	NP_608762.3	STYKc	426..763	CDD:214568	107/340 (31%)
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	106/333 (32%)
Ror	NP_476962.1	CRD_TK_ROR_like	39..228	CDD:143568	38/198 (19%)
		KR	235..312	CDD:214527	11/76 (14%)
		PTKc_Ror	404..673	CDD:270642	108/343 (31%)
		Pkinase_Tyr	410..670	CDD:285015	106/337 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455314
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.940