DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3277 and Pvr

DIOPT Version :9

Sequence 1:	NP_608762.3	Gene:	CG3277 / 33543	FlyBaseID:	FBgn0031518	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster

Alignment Length:	864	Identity:	203/864 - (23%)
Similarity:	351/864 - (40%)	Gaps:	221/864 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 PTLISLVRSSEKEPEQMESHRYVTGLSEP----IAMEPLTRMRLNPNPDGEITELTTNV------ 89
            || .|::..:...|.:.|.:::.|   .|    :::|.:..:...|...|.:|.:..|:
  Fly   580 PT-CSVLNQNFSLPSEQEKYQFQT---RPRPGKLSVERIYEVSFLPTEPGILTCIAQNIIDGKER 640

  Fly    90 -TLYMEKIPRLQVRWQDNLPQGTSYNVLVSAVNNSRCPDAPCSEYGIKEKNASAETHSVNLPVNP 153
             ||                   |..:||:..::.:      .:.||..      :.|.:....|.
  Fly   641 RTL-------------------TKAHVLLGNISEN------MTIYGFD------KDHKIAKEDNV 674

  Fly   154 NLNVESVDCNYMFGCQY-----------QVIVETSNAMVRRSARVYIPQCLE---GKCSCQLAPT 204
            |...|::..::....::           .|.:|||:......:.|:|....:   |...|:....
  Fly   675 NFTCEALAYHFDGNLKWFINGEDLKESDSVHIETSHTKYSYKSTVHITTISDRDRGTYECRAYHN 739

  Fly   205 PPKVLAVAKMLSNETISINLSI---LASELLRKEQDSH------LHETL--------------RT 246
            ....:..::       .|:|.:   .|.:.....|:.|      |.:||              |.
  Fly   740 DKDAVYSSR-------EIDLYVHDPSAPQWTNGGQEGHSKIKRKLSQTLELECASTAVPVAIVRW 797

  Fly   247 YKMQLKINEETNPSLPWGGVLKHLMTRVYKLSELNFRATPKGFEGVMKLGLGTQLKEKASLSLQA 311
            :|...::.|..         |:|:   :.|.|:|.......|.|||.|..:..:| ::...|...
  Fly   798 FKDDKEVTESK---------LRHI---IEKESKLLITHLYPGDEGVYKCVVENRL-DRIERSFTV 849

  Fly   312 VIIDPTGCEGPRSVTKVPVPANPVLLTEGDSVSNSIIVMSAMLIAIILAGLIMLLLRRRRARTTA 376
            ||.|..|.                         :...|...:::.:||.||.:.|        ..
  Fly   850 VISDLPGI-------------------------SMAWVWFGVILFLILIGLCVFL--------AV 881

  Fly   377 KLRKQEQIYIQTFATSAIEMEDN-VNYVDKYV---EKSQVLGLADIFEVPHSAIQIGRMLGEGAF 437
            :.:|:.:.::...|......|:. |.:::..:   |::::|.....||.|...:::|:.||.|||
  Fly   882 RYQKEHKRHLALKAAGLANFEEGAVGHINPDLTLDEQAELLPYNREFEFPRENLKLGKQLGAGAF 946

  Fly   438 GQVHEATAINLRRMRGTTIVAVKQLKPNPKADEVAEYLAEIEMLKGVGTHHNVVSFLGCCT---I 499
            |.|.:..|..:||...||.||||.:|.....:.|...::|::::..:|.|.|||:.||..|   .
  Fly   947 GVVLKGEAKGIRREEPTTTVAVKMVKATADNEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNIA 1011

  Fly   500 KPPYLMIMEYVNKGNLLSYLRTVRKEASKLRNRNANYTSCRP--------IMTRTNSTSSPKSQS 556
            |...::|:||...||:.::|         ||||........|        |||:..|.:....:.
  Fly  1012 KRELMVIVEYCRFGNIQNFL---------LRNRKCFINQINPDTDHIDPSIMTQRMSDNYELHRD 1067

  Fly   557 VNYIELKASS------QTIEMPQEDST---AH--------MNGIRQPHPSFAETTY--------- 595
            .|...||.::      ..|..|..::|   .|        .:|.|.........||
  Fly  1068 TNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTATYSYDRQMDTC 1132

  Fly   596 -----TIVEDEDAF-----------EYILDNKE--------LHNFALQIANGMRFLEEQEITHRD 636
                 |:.||:...           .|..|:.|        |.::|.|:|.||.:|..:::.|.|
  Fly  1133 ATVMTTVPEDDQIMSNNSVQPAWRSNYKTDSTEAMTVTTVDLISWAFQVARGMDYLSSKKVLHGD 1197

  Fly   637 LAARNVLIDSNKTLKISDFGLSRH----GIYTNTRTRKLPLRWLSIEAIRENVYSSKSDIWAYGV 697
            |||||:|:..:..:||.||||:|.    ..|..:...|||::||::|::.::|:|:.||:|:||:
  Fly  1198 LAARNILLCEDNVVKICDFGLARSMYRGDNYKKSENGKLPIKWLALESLSDHVFSTYSDVWSYGI 1262

  Fly   698 VLWEIGTLGASPYPTIS-NDELIPFLMAGNRLERPEICTPQVYTIMLQCWLEEPEERPTFDALYK 761
            ||||:.:|...|||.|. |.||...|..|.|:|:|:....::|.|||:||.:.||.||.|..|.|
  Fly  1263 VLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLFAELEK 1327

  Fly   762 VLS------PKTTYVDINS 774
            ..:      ..:.|:|:|:
  Fly  1328 RFANMLGEDVASHYLDLNN 1346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3277	NP_608762.3	STYKc	426..763	CDD:214568	127/402 (32%)
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	126/398 (32%)
Pvr	NP_001162911.1	IG	346..432	CDD:214652
		Ig	<363..432	CDD:299845
		Ig	466..533	CDD:299845
		IG_like	672..754	CDD:214653	13/88 (15%)
		Ig	674..739	CDD:143165	10/64 (16%)
		IGc2	779..840	CDD:197706	15/72 (21%)
		PKc_like	927..1332	CDD:304357	130/413 (31%)
		Pkinase_Tyr	935..1329	CDD:285015	127/402 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455283
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840