DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3277 and tek

DIOPT Version :9

Sequence 1:	NP_608762.3	Gene:	CG3277 / 33543	FlyBaseID:	FBgn0031518	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	XP_009299388.1	Gene:	tek / 30747	ZFINID:	ZDB-GENE-990415-56	Length:	1117	Species:	Danio rerio

Alignment Length:	799	Identity:	192/799 - (24%)
Similarity:	316/799 - (39%)	Gaps:	230/799 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 LNPNP---DGEITELTTNVTLYMEKIPRLQVRWQ-----------DNLPQGTSYNVLVSAVNNSR 124
            ||..|   ||.|   .|...||.   |.....|.           |||...|.|   ::.|..||
Zfish   463 LNTEPYSGDGPI---ATTTLLYR---PASAHTWSSFTAHGPLVRLDNLYPMTQY---LTQVQLSR 518

  Fly   125 CPDAPCSEYGIKEKNASAETHSVNLPVNPNLNVES--------------VDCNYMFGC------- 168
            .......:.|   ..|:..|..:.|||...|:..|              ..|.|...|
Zfish   519 PGPGGAGQAG---PAATFSTQVLELPVGVKLSAVSQTALLLSWDIAPAEQHCTYEVSCLQAGAPG 580

  Fly   169 ---QYQVIVETSNAM--------------VRRSARV--YIPQCLEGKCSCQLAPTPPKVLAVAKM 214
               .:| :...|:||              ||.|..|  ..|.......|....|.||..:::..:
Zfish   581 TLRTFQ-LPSNSSAMHLSDLKPRHKYQCTVRSSCGVGQNHPSASAWTLSDPELPPPPANISIWNI 644

  Fly   215 LSNETI---------SINLSILASELLRKEQDSHLHETLRTYKMQLKINEETNPSLPWGGVLKHL 270
            .....:         |::.:::..:.:.:.|          |:.|:::..:|
Zfish   645 SDTSAVLTWAVAEGESVSRAVIRFQQVEQAQ----------YRQQVELPVQT------------- 686

  Fly   271 MTRVYKLSELNFRATPKGFEGVMKLGLGTQLKEKASLSLQAVIIDPTG--CEGPRSVTKVPVP-- 331
                   .:|:.|....|            |:......||...::..|  .|.| .|:.:.:|
Zfish   687 -------QQLHMRFQLLG------------LRPNTGYQLQLWTVNNMGESAESP-PVSLMTLPQQ 731

  Fly   332 -ANPVLLTEGDSVSNSIIVMSAM-LIAIILAGLIMLLLRRR--RARTTAKLRKQEQIYIQTFATS 392
             ::.:....|..:..:|:..:.| ...::||..|:|.|:|.  :.|..:.||::..::..:....
Zfish   732 ESSALFAAHGHLLLYAILGSAGMTCCTVLLAFCIVLQLKRNTLQRRIHSILREEPAVHFSSAPPP 796

  Fly   393 AIEMEDNVNYVDKYVEKSQVLGLADIF-EVPHSAIQIGRMLGEGAFGQVHEATAINLRRMRGTTI 456
            .              .:|.|:..:.:| .:..|.||...:||||.||||.:|      |:|...:
Zfish   797 H--------------RRSAVVSRSLVFPALQWSDIQFQDVLGEGNFGQVLKA------RIRKDGL 841

  Fly   457 ---VAVKQLKPNPKADEVAEYLAEIEMLKGVGTHHNVVSFLGCCTIKPPYLMIMEYVNKGNLLSY 518
               .|||::|.....|:..::..|:|:|..:|.|.|::..||.|..:....:.:|:...||||.:
Zfish   842 RMDAAVKRMKDYASQDDHRDFAGELEVLCRLGPHKNIIHLLGACEHRGYLYLAIEFAPHGNLLDF 906

  Fly   519 LRTVRKEASKLRNRNANYTSCRPIMTRTNSTSSPKSQSVNYIELKASSQTIEMPQEDSTAHMNGI 583
            ||..|                                                           :
Zfish   907 LRKSR-----------------------------------------------------------V 912

  Fly   584 RQPHPSFA---ETTYTIVEDEDAFEYILDNKELHNFALQIANGMRFLEEQEITHRDLAARNVLID 645
            .:..|:||   .|..|           |.:::|..|:..:|.||.:|.:::..||||||||||:.
Zfish   913 LETDPAFAIAHRTAST-----------LSSQQLLAFSADVARGMSYLSQKQFIHRDLAARNVLVG 966

  Fly   646 SNKTLKISDFGLSR-HGIYTNTRTRKLPLRWLSIEAIRENVYSSKSDIWAYGVVLWEIGTLGASP 709
            .|...||:|||||| ..:|......:||:||::||::..:||::.||:|:|||:|||:.:||.:|
Zfish   967 ENFVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEVVSLGGTP 1031

  Fly   710 YPTISNDELIPFLMAGNRLERPEICTPQVYTIMLQCWLEEPEERPTFD----ALYKVLSPKTTYV 770
            |..::..||...|..|.|||:|..|..:||.:|.|||.|:|.|||:|.    :|.::|..:.|||
Zfish  1032 YCGMTCAELYEKLPLGFRLEKPLNCDDEVYELMQQCWREKPFERPSFSQILLSLGRMLEERKTYV 1096

  Fly   771 DINSLSDDYVFPPISENRE 789
            : .:|.:.:.:..|..:.|
Zfish  1097 N-TTLYEKFTYAGIDCSAE 1114

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3277	NP_608762.3	STYKc	426..763	CDD:214568	110/347 (32%)
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	108/343 (31%)
tek	XP_009299388.1	Ig_Tie2_1	25..121	CDD:287411
		EGF_2	224..255	CDD:285248
		IG_like	354..439	CDD:214653
		fn3	541..621	CDD:278470	15/80 (19%)
		FN3	633..717	CDD:214495	15/125 (12%)
		PTKc_Tie2	809..1111	CDD:133219	118/378 (31%)
		STYKc	817..1085	CDD:214568	109/343 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910