DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3277 and tie1

DIOPT Version :9

Sequence 1:	NP_608762.3	Gene:	CG3277 / 33543	FlyBaseID:	FBgn0031518	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	XP_001334673.5	Gene:	tie1 / 30746	ZFINID:	ZDB-GENE-990415-55	Length:	1122	Species:	Danio rerio

Alignment Length:	784	Identity:	179/784 - (22%)
Similarity:	294/784 - (37%)	Gaps:	259/784 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 NLPQGTSYNVLVSAVNNSRCPDAPCSEYGIKEKNASAETHSVNLPVNPNLNVESVDCNYMFGCQY 170
            ||...|.|:|.|.........:.|.....|.|.:....|      ..|.::..|
Zfish   496 NLKPSTKYHVRVQLARPGEGGEGPLGPEAIMETDCPEPT------ARPEIDSSS----------- 543

  Fly   171 QVIVETSNAMVR-------RSARVYIPQCLEGKCSCQLAPTPPKVLAVAKMLSNETISINLSILA 228
               :|..|..:|       |.|..::.| |.|              ...:.|..||..:|  :|:
Zfish   544 ---LEGRNVTLRWSLIGRFREASGFLVQ-LYG--------------PYGEKLWEETTFLN--VLS 588

  Fly   229 SELLRKE---------------------QDSHLHETLRTYKMQLKINEETNPSLPWGGVLKHLMT 272
            .:|...|                     :..|:|    .||.        .||.|     :::..
Zfish   589 VKLYNLEYHKNYQAVVRLVNCGSHGPPSRPHHIH----IYKQ--------GPSSP-----RNVQA 636

  Fly   273 RVYKLSELNFR----ATPKGFEGVMKLGLGTQLKEKASL-------SLQAVIIDPTGCEGP---- 322
            ....:|.:..|    ..|.|  |::|..:..|...::||       :......|.|...|.
Zfish   637 DALSISAVRLRWQPPEDPNG--GIVKYSIEYQPVGQSSLHPWVDTDNGNKTTKDVTSLNGSTLYQ 699

  Fly   323 ---RSVTKVP------VPANPVLLTEGDSVSNSI-----------------------IVMSAMLI 355
               |:.:|||      |.|.    |.|:.:|:.|                       :.::.:.|
Zfish   700 FRVRAFSKVPGEWSSFVQAQ----TPGEGLSSFIPTTQQVGRPLAEDHQLLFAVVGSVAVTCVTI 760

  Fly   356 AIILAGLIML---LLRRRRART----------------TAKLRKQEQIYIQTFATSAIEMEDNVN 401
            .:.|..|..:   :|:|||..|                |..|.::.:...:......:|.||
Zfish   761 LLALLALFYIRKSVLKRRRTFTYQSGSGEETILQFNSGTLTLTRRPKPSPEPLTYPILEWED--- 822

  Fly   402 YVDKYVEKSQVLGLADIFEVPHSAIQIGRMLGEGAFGQVHEATAINLRRMRGTTI-VAVKQLKPN 465
                                    |:...::|||.||||.:|    :.:..|..: .|:|.||..
Zfish   823 ------------------------IKFEDVIGEGNFGQVIKA----MVKKDGIKMSAAIKMLKEF 859

  Fly   466 PKADEVAEYLAEIEMLKGVGTHHNVVSFLGCCTIKPPYLMIMEYVNKGNLLSYLRTVRKEASKLR 530
            ...::..::..|:|:|..:|.|.|:::.:|.|..:....:.:||...||||.:||..|
Zfish   860 ASENDHRDFAGELEVLCKLGQHTNIINLIGACENRGYLYIAIEYAPYGNLLDFLRKSR------- 917

  Fly   531 NRNANYTSCRPIMTRTNSTSSPKSQSVNYIELKASSQTIEMPQEDSTAHMNGIRQPHPSFAETTY 595
                                                                :.:..|:||:
Zfish   918 ----------------------------------------------------VLETDPAFAK--- 927

  Fly   596 TIVEDEDAFEYILDNKELHNFALQIANGMRFLEEQEITHRDLAARNVLIDSNKTLKISDFGLSR- 659
                 |......|.:::|..||..:|.||.:|.:::..||||||||||:..|...||:||||||
Zfish   928 -----EHGTASTLTSQQLLQFAADVATGMHYLSDKQFIHRDLAARNVLVGDNLVAKIADFGLSRG 987

  Fly   660 HGIYTNTRTRKLPLRWLSIEAIRENVYSSKSDIWAYGVVLWEIGTLGASPYPTISNDELIPFLMA 724
            ..:|......:||:||::||::..:||::|||:|::||:||||.:||.:||..::..||...|..
Zfish   988 EEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQ 1052

  Fly   725 GNRLERPEICTPQVYTIMLQCWLEEPEERPTFD----ALYKVLSPKTTYVDINSLSDDYVFPPIS 785
            |.|:|:|..|..:||.:|.|||.:.|.|||.|.    .|.::...:..||:: :|.:::.:..|.
Zfish  1053 GYRMEQPRNCDDEVYELMRQCWRDRPYERPPFSQISVQLNRMQEARKAYVNM-ALFENFTYAGID 1116

  Fly   786 ENRE 789
            ...|
Zfish  1117 ATAE 1120

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3277	NP_608762.3	STYKc	426..763	CDD:214568	105/342 (31%)
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	104/338 (31%)
tie1	XP_001334673.5	EGF_CA	<219..244	CDD:238011
		IG_like	346..431	CDD:214653
		fn3	<461..508	CDD:278470	5/11 (45%)
		fn3	538..616	CDD:278470	16/108 (15%)
		FN3	628..720	CDD:238020	21/102 (21%)
		PKc_like	820..1116	CDD:304357	110/394 (28%)
		Pkinase_Tyr	823..1091	CDD:285015	104/338 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900