DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3277 and ret

DIOPT Version :9

Sequence 1:	NP_608762.3	Gene:	CG3277 / 33543	FlyBaseID:	FBgn0031518	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_858048.2	Gene:	ret / 30512	ZFINID:	ZDB-GENE-980526-307	Length:	1106	Species:	Danio rerio

Alignment Length:	838	Identity:	210/838 - (25%)
Similarity:	338/838 - (40%)	Gaps:	259/838 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 HRYVTGLSEPIAMEPLTRMRLN--------PNPDGEITELTTNVTLYMEKIPRLQVRWQDNLPQ- 109
            |.|...||:.:::.......|.        |.|:|.:. |..|||:....|....|.:...:.|
Zfish   337 HEYKLKLSQNLSVTEQRSFLLGYLVNDTTFPGPEGTVL-LHFNVTVLPVPIRFSNVTYSFTVSQK 400

  Fly   110 GTSYNVLVS-AVNNSRCPDAPCSEY---------GIKEKNASAETHS----VNLPVNPNLNVESV 160
            .|:|:.:.. .|.|       |.::         .|.::|.:||..|    |:|..|||.|.
Zfish   401 ATTYSQIGKVCVEN-------CQKFKGIDVTYQLEIVDRNITAEAQSCYWAVSLAQNPNDNT--- 455

  Fly   161 DCNYMFGCQYQVIVETSNAMVRRSARVYIPQCLEGKCSCQLAPTPPKVLAVAKMLSNETISINLS 225
                      .|:......::||      |:|.|
Zfish   456 ----------GVLYVNDTKVLRR------PECQE------------------------------- 473

  Fly   226 ILASELLRKEQDSHLH-ETLRTYKMQ-----LKINEETNPS-----------------LPWG--- 264
             |...::.:||.:.|. :|..|...|     ||.:|...|:                 .|.|
Zfish   474 -LEYVVIAQEQQNKLQAKTQLTVSFQGEADSLKTDEPRFPACAEKRQRGDCEATRGLGAPTGRCQ 537

  Fly   265 -------GVLKHLMTRVYKLSELNFRATPKGFEGVMKLGLGTQLKEKASLSLQAVIIDPTGCEG- 321
                   |:.|.     |.....|....|.|:...:         |..::|     |.|..|..
Zfish   538 WRQGRDKGISKR-----YSTCSPNLGTCPDGYCDAI---------ESKNIS-----ICPQDCSSE 583

  Fly   322 ------PRSVTKVPVPANPVLLTEG----------DSVSNSI---IVMSAMLIAIILAGLIMLLL 367
                  .|.:..:..........||          |.:.|.:   ::.:.::::.|::.|:....
Zfish   584 AIIGGYERDLYGIKAGHGTCYCFEGKCFCERDEPEDDICNDMCKTVIATGIILSFIVSVLLSSYF 648

  Fly   368 RRRRARTTAK---------LRKQEQIYIQTFATSAI------EMEDNVNYVD--KYVEKSQVLGL 415
            ..|..:||.|         .|:..|.|..:::.:.:      .||:.| .:|  |..|..:
Zfish   649 IHRYHKTTPKPPIASAEMTFRRPAQSYPISYSANNVRRASLDSMENQV-AIDTFKIPEDPK---- 708

  Fly   416 ADIFEVPHSAIQIGRMLGEGAFGQVHEATAINLRRMRGTTIVAVKQLKPNPKADEVAEYLAEIEM 480
               :|.|...:.:|:.||||.||:|.:|||..|:...|.|.||||.||.|....|:.:.|:|..:
Zfish   709 ---WEFPRKNLVLGKTLGEGEFGKVVKATAFRLKGKAGYTTVAVKMLKENASHSELRDLLSEFTL 770

  Fly   481 LKGVGTHHNVVSFLGCCTIKPPYLMIMEYVNKGNLLSYLRTVRKEASKLRNRNANYTSCRPIMTR 545
            ||.| .|.:|:...|.|:...|..:|:||...|:|.::||..||........:||..|
Zfish   771 LKQV-NHPHVIKMYGACSQDGPLYLIVEYAKYGSLRNFLRESRKVGPSYMGNDANRNS------- 827

  Fly   546 TNSTSSPKSQSVNYIELKASSQTIEMPQEDSTAHMNGIRQPHPSFAETTYTIVEDEDAFEYILDN 610
                        :|:|                         :|           ||.|    |..
Zfish   828 ------------SYLE-------------------------NP-----------DERA----LTM 840

  Fly   611 KELHNFALQIANGMRFLEEQEITHRDLAARNVLIDSNKTLKISDFGLSR----HGIYTNTRTRKL 671
            .:|.:||.||:.||::|.|.::.||||||||||:...:.:|||||||||    ...|......::
Zfish   841 GDLISFAWQISRGMQYLAEMKLVHRDLAARNVLVAEGRKMKISDFGLSRDVYEEDSYVKRSKGRI 905

  Fly   672 PLRWLSIEAIRENVYSSKSDIWAYGVVLWEIGTLGASPYPTISNDELIPFLMAGNRLERPEICTP 736
            |::|::||::.:::|:::||:|::||:||||.|||.:|||.|:.:.|...|..|.|:|:||.||.
Zfish   906 PVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIAPERLFNLLKTGYRMEKPENCTD 970

  Fly   737 QVYTIMLQCWLEEPEERPTFD----ALYKVLSPKTTYVDI------------NSLSDD 778
            ::|.:||:||.:|.::||||.    .|.|::.....|:|:            :|||::
Zfish   971 EMYNLMLRCWKQESDKRPTFSDISKELEKMMVKSRDYLDLAASTPADALLYDDSLSEE 1028

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3277	NP_608762.3	STYKc	426..763	CDD:214568	122/344 (35%)
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	121/340 (36%)
ret	NP_858048.2	CA	186..256	CDD:214520
		PTKc_RET	715..1004	CDD:173631	122/348 (35%)
		Pkinase_Tyr	716..997	CDD:285015	120/340 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810