DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3277 and kita

DIOPT Version :9

Sequence 1:	NP_608762.3	Gene:	CG3277 / 33543	FlyBaseID:	FBgn0031518	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	XP_009292910.1	Gene:	kita / 30256	ZFINID:	ZDB-GENE-980526-464	Length:	981	Species:	Danio rerio

Alignment Length:	855	Identity:	216/855 - (25%)
Similarity:	347/855 - (40%)	Gaps:	252/855 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 MESHRY-VTGLSEPIAMEPLT-----RMRLNPNPDGEITELTTNVTLYMEKIPRLQVRWQDNLPQ 109
            ::|.|| :|....|.|..|:|     |:.|.......::..|:||.      ..:.|:|:  .|.
Zfish   194 VKSGRYQLTVRLVPDAPPPITLGQPQRVLLTQGEKLSLSCSTSNVN------SDIAVKWK--APN 250

  Fly   110 GTSYNV-------------------LVSAVNNSRCPDAPCSEYGIKEKNASAETHSVNLPVNPNL 155
            |.:.:|                   .:|:|......:..|.  .|.||..:|:...||:.....:
Zfish   251 GVNPSVHQNSHLLTEPITHVRTAILSLSSVTMQDAGNYSCE--AINEKGTTAKPVWVNIYEKGFI 313

  Fly   156 NVESVDCN----------------------YMFGCQYQVIVETS--------------------- 177
            |:.|||.:                      :.|...|..:..|:
Zfish   314 NITSVDNSTRRVRAGESLSLRVVMNAYPKPHTFSWSYSGVKLTNTTDHVITSRTHGNSYTSELKL 378

  Fly   178 ------------------NAMVRRSARVYI---PQCL--EG------KCSCQLAPTPPKVLAVAK 213
                              :|.:|::..|::   ||.:  ||      :|..:..|||........
Zfish   379 VRLKVSESGIYTFSCLNRDATIRQTFEVHVISKPQIVSYEGPIDGQVRCVAEGYPTPQIKWYYCD 443

  Fly   214 MLSNETISINLSILASELLRKEQDSHLHETLRTYKMQLKINEETNPSLPWGGVLKHLMTRVYKLS 278
            :..:.         .|.||...|:   .|.:.|..|       |||  |:|
Zfish   444 LPHSR---------CSNLLNATQE---EEDVVTVTM-------TNP--PFG-------------- 473

  Fly   279 ELNFRATPKGFEGVMKLGLGTQLKEKASLSLQAVIIDPTGCEGPRSVTKVPVPANPVLLTEGDSV 343
                       :|.::..|.......|:|...|                   .||..::....|:
Zfish   474 -----------KGAVESRLNITKNNYATLECVA-------------------SANGEIVYTLFSI 508

  Fly   344 SNSII---VMSAMLIAIILAGLIMLLLRRRRARTTAKLRKQEQIYIQTFATSAIEMEDNVNYVDK 405
            |.:.:   :.:.:||..:.|.:|::|:   ....|.|..::.:..||   ...||.....|||
Zfish   509 SENTVPHELFTPLLIGFVAAAVILVLI---LIVLTYKYMQKPKYQIQ---WKVIEGIHGNNYV-- 565

  Fly   406 YVEKSQVLGLADIFEVPHSAIQIGRMLGEGAFGQVHEATAINLRRMRGTTIVAVKQLKPNPKADE 470
            |::.:| |.....:|.|...::.|:.||.||||:|.||||..:.:......||||.|||:..|.|
Zfish   566 YIDPTQ-LPYDHQWEFPRDKLRFGKTLGSGAFGKVVEATAYGMSKADTVMTVAVKMLKPSAHATE 629

  Fly   471 VAEYLAEIEMLKGVGTHHNVVSFLGCCTIKPPYLMIMEYVNKGNLLSYLR--------TVRKEAS 527
            ....::|:::|..:|.|.|:|:.||.||:..|.|:|.||...|:||::||        |...|.:
Zfish   630 KEALMSELKVLSYLGNHINIVNLLGACTVGGPTLVITEYCCFGDLLNFLRRRRVYFYYTTLGEDA 694

  Fly   528 KLRN----------RNANYTSCRP----IMTRTNSTSSPKSQSVNYIELKASSQTIEMPQEDSTA 578
            ..||          || .|.:.:|    |::..|..|..|..|  |.:..|.|   |:.|||...
Zfish   695 YYRNVMMQSEPNDSRN-GYMTMKPSVLGILSSENRRSLNKGDS--YSDSDAVS---EILQEDGLT 753

  Fly   579 HMNGIRQPHPSFAETTYTIVEDEDAFEYILDNKELHNFALQIANGMRFLEEQEITHRDLAARNVL 643
                                         ||.::|.:|:.|:|.||.||..:...||||||||:|
Zfish   754 -----------------------------LDTEDLLSFSYQVAKGMDFLASKNCIHRDLAARNIL 789

  Fly   644 IDSNKTLKISDFGLSRHGIYTNTR-----TRKLPLRWLSIEAIRENVYSSKSDIWAYGVVLWEIG 703
            :...:..||.||||:| .|.|::.     ..:||::|:|.|:|.|.||:.:||:|:||::||||.
Zfish   790 LTQGRVAKICDFGLAR-DITTDSNYVVKGNARLPVKWMSPESIFECVYTFESDVWSYGILLWEIF 853

  Fly   704 TLGASPYPTISND-ELIPFLMAGNRLERPEICTPQVYTIMLQCWLEEPEERPTF----DALYKVL 763
            :||:||||.:..| :....:..|.|:|.||....::|.||..||..:|.:||:|    :.:.:.:
Zfish   854 SLGSSPYPGMPVDSKFYKMIKEGYRMESPEFSPSEMYDIMHSCWDADPVKRPSFSKIVEKIEQQI 918

  Fly   764 SPKTTYVDIN 773
            |..|.::.:|
Zfish   919 SDSTKHIYLN 928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3277	NP_608762.3	STYKc	426..763	CDD:214568	128/368 (35%)
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	127/364 (35%)
kita	XP_009292910.1	IG_like	123..203	CDD:214653	3/8 (38%)
		IG_like	218..307	CDD:214653	18/98 (18%)
		ig	218..297	CDD:278476	15/88 (17%)
		Ig	311..410	CDD:299845	10/98 (10%)
		IG_like	325..408	CDD:214653	6/82 (7%)
		PTKc_Kit	549..918	CDD:270682	140/410 (34%)
		Pkinase_Tyr	585..914	CDD:285015	128/364 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810