Protein Alignment CG3277 and Fer

DIOPT Version :10

• Sequence 1: NP_608762.3
• Gene: CG3277 / 33543
• FlyBaseID: FBgn0031518
• Length: 789
• Species: Drosophila melanogaster
• Sequence 2: NP_001382687.1
• Gene: Fer / 301737
• RGDID: 1306273
• Length: 823
• Species: Rattus norvegicus
• Alignment Length: 759
• Identity: 183/759 - (24%)
• Similarity: 309/759 - (40%)
• Gaps: 184/759 - (24%)

  Fly    52 ESHRYVTGLSEPIAMEPLTRMRLNP--------NPDGEITELTTNVTLYMEKIPRLQVRWQDNLP 108
            :|..|.|.|  |:.::.:.:|:...        :...|||.|.|...:.:.|..::.|   |.:.
  Rat   196 QSQYYDTTL--PLLLDSVQKMQEEMIKALKGIFDEYSEITSLVTEEIVNVHKEIQMSV---DQID 255

  Fly   109 QGTSYNVLVSAVNNSRCPDAPCSEYGIKEKNASAETHSVNLPVNPNLNVESVDCNYMFGCQYQV- 172
            ..|.||..:.....:          ..||:....:|..  |..|.||....:..|.:.....||
  Rat   256 PSTEYNDFIDVHRTT----------AAKEQEIEFDTSL--LEENENLQANEIMWNNLTADSLQVM 308

  Fly   173 -------IVETSNAMVRRSARVYIPQCLEGKCSCQLAPTPPKVLAVAKMLSNETISINLSILASE 230
                   :.:|...::.:.|.|..   ||.:.. :.:.|..|...:..:|..:.....|.....:
  Rat   309 LKTLAEELTQTQQMLLHKEAAVLE---LEKRIE-ESSETCAKKSDIVLLLGQKQALEELKQSVQQ 369

  Fly   231 LLRKEQDSHLHETLRTYKMQLKINEETNPSLPWGGVLKHL--MTRVYKLSELNFRATPKGFEGVM 293
            |...|......:.|...|:|....:|..|.:.:....:.:  |.|..:||:  |.:......|::
  Rat   370 LRCTEAKCAAQKELLEQKVQENDGKEPPPVVNYEEDARSVTSMERKERLSK--FESIRHSIAGII 432

  Fly   294 K-----LGLGTQLKEKASLSLQAVIIDPTGCEG--PRSVTKVPVPANPVLLTEGD-SVSNSIIVM 350
            |     ||..|||.:..|:. :..:.:.....|  ||      :.|..:|..:|| .|..|....
  Rat   433 KSPKSVLGSSTQLSDVISVG-EKPLAEHDWYHGAIPR------IEAQELLKQQGDFLVRESHGKP 490

  Fly   351 SAMLIAIILAGLIMLLLRRRRARTTAKLRKQEQIYIQTFATSAIEME----DNV-NYVDKYVEKS 410
            ...::::...|                   |.:.:|..|..:....|    .|: ..:|.:....
  Rat   491 GEYVLSVYSDG-------------------QRRHFIIQFVDNLYRFEGTGFSNIPQLIDHHFNTK 536

  Fly   411 QVL----GLADIFEVP--------HSAIQIGRMLGEGAFGQVHEATAINLRRMRGTTIVAVKQLK 463
            ||:    |:..:..:|        |..:.:|.:||:|.||:|::.|      ::..|.||||..|
  Rat   537 QVITKKSGVVLLNPIPKDKKWVLNHEDVSLGELLGKGNFGEVYKGT------LKDKTPVAVKTCK 595

  Fly   464 PNPKADEVAEYLAEIEMLKGVGTHHNVVSFLGCCTIKPPYLMIMEYVNKGNLLSYLRTVRKEASK 528
            .:...:...::|.|.::||.. .|.|:|..:|.||.:.|..:|||.|..|:.||:||. ||:..|
  Rat   596 EDLPQELKIKFLQEAKILKQY-DHPNIVKLIGVCTQRQPVYIIMELVPGGDFLSFLRK-RKDELK 658

  Fly   529 LRNRNANYTSCRPIMTRTNSTSSPKSQSVNYIELKASSQTIEMPQEDSTAHMNGIRQPHPSFAET 593
            |
  Rat   659 L---------------------------------------------------------------- 659

  Fly   594 TYTIVEDEDAFEYILDNKELHNFALQIANGMRFLEEQEITHRDLAARNVLIDSNKTLKISDFGLS 658
                             |:|..|:|.:|.||.:||.:...||||||||.|:..|.||||||||:|
  Rat   660 -----------------KQLVRFSLDVAAGMLYLEGKNCIHRDLAARNCLVGENNTLKISDFGMS 707

  Fly   659 RH---GIYTNTRTRKLPLRWLSIEAIRENVYSSKSDIWAYGVVLWEIGTLGASPYPTISNDELIP 720
            |.   |:|:::..:::|::|.:.||:....|||:||:|::|::|||..:||..|||.::|.:...
  Rat   708 RQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQARE 772

  Fly   721 FLMAGNRLERPEICTPQVYTIMLQCWLEEPEERPTFDALYKVLS 764
            .:..|.|:..|:.|..:::|||::||..:||.||.|..|:|.|:
  Rat   773 QVERGYRMSAPQNCPEEIFTIMMKCWDYKPENRPKFSDLHKELT 816

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	104/335 (31%)
Fer	NP_001382687.1	Important for interaction with membranes containing phosphoinositides. /evidence=ECO:0000250	1..300		25/120 (21%)
		F-BAR_Fer	5..238	CDD:153370	10/43 (23%)
		SH2_Fps_family	454..539	CDD:198224	17/109 (16%)
		Protein Kinases, catalytic domain	567..817	CDD:473864	106/339 (31%)