DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3277 and Fgfr4

DIOPT Version :9

Sequence 1:	NP_608762.3	Gene:	CG3277 / 33543	FlyBaseID:	FBgn0031518	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	XP_006253668.1	Gene:	Fgfr4 / 25114	RGDID:	2612	Length:	801	Species:	Rattus norvegicus

Alignment Length:	676	Identity:	186/676 - (27%)
Similarity:	291/676 - (43%)	Gaps:	185/676 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 YQVIVETSNAMVRRSARVYIPQCLEGKCSCQLAPTPPKVLAVAKMLSNETISINLSILASELLRK 234
            |..:||.|...:|.|   |:...||        .:|.:.:..|.:.:|.|..:..::   |||
  Rat   218 YTCLVENSLGSIRYS---YLLDVLE--------RSPHRPILQAGLPANTTAVVGSNV---ELL-- 266

  Fly   235 EQDSHLHETLRTYKMQLKINEETNPSLPWGGVLKHLMTRVYKLSELNFRATPKGFEGVMKLGLGT 299
                            .|:..:..|.:.|   |||::     ::..:|.|....:..|:|.   |
  Rat   267 ----------------CKVYSDAQPHIQW---LKHIV-----INGSSFGADGFPYVQVLKT---T 304

  Fly   300 QL--KEKASLSLQAVIIDPTG---CEGPRSVTKVPVPANPVLLTEGDS----------------- 342
            .:  .|...|.|:.|..:..|   |....|:......|...:|.|.:.
  Rat   305 DINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEAEEEDLAWTTATSEARYTDI 369

  Fly   343 ---VSNSIIVMSAMLIAIILAGLIMLLL----RRRRARTTAK-----LRKQEQIYIQTFATSAIE 395
               ||.|:    |:::.::|||:.....    ..|:..|..|     |.:|..:..::...|::.
  Rat   370 ILYVSGSL----ALVLLLLLAGVYHRQAIHGHHSRQPVTVQKLSRFPLARQFSLESRSSGKSSLS 430

  Fly   396 MEDNVNY-------------VDKYVEKSQVLGLADIFEVPHSAIQIGRMLGEGAFGQVHEATAIN 447
            :...|..             :|        |.|..::|.|...:.:|:.||||.||||..|.|:.
  Rat   431 LVRGVRLSSSGPPLLTGLVSLD--------LPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEALG 487

  Fly   448 LRRMR--GTTIVAVKQLKPNPKADEVAEYLAEIEMLKGVGTHHNVVSFLGCCTIKPPYLMIMEYV 510
            :...|  .|:.||||.||.|....::|:.::|:||:|.:|.|.|:::.||.||.:.|..:|:||.
  Rat   488 MDSSRPDQTSTVAVKMLKDNASDKDLADLISEMEMMKLIGRHKNIINLLGVCTQEGPLYVIVEYA 552

  Fly   511 NKGNLLSYLRTVRKEASKLRNRNANYTSCRPIMTRTNSTSSPKSQSVNYIELKASSQTIEMPQED 575
            .||||..:||..|.....|                  |...|:|          |...:..|
  Rat   553 AKGNLREFLRARRPPGPDL------------------SPDGPRS----------SEGPLSFP--- 586

  Fly   576 STAHMNGIRQPHPSFAETTYTIVEDEDAFEYILDNKELHNFALQIANGMRFLEEQEITHRDLAAR 640
                                                .|.:.|.|:|.||::||.::..|||||||
  Rat   587 ------------------------------------ALVSCAYQVARGMQYLESRKCIHRDLAAR 615

  Fly   641 NVLIDSNKTLKISDFGLSR--HGI--YTNTRTRKLPLRWLSIEAIRENVYSSKSDIWAYGVVLWE 701
            |||:..:..:||:||||:|  |.|  |..|...:||::|::.||:.:.||:.:||:|::|::|||
  Rat   616 NVLVTEDDVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWE 680

  Fly   702 IGTLGASPYPTISNDELIPFLMAGNRLERPEICTPQVYTIMLQCWLEEPEERPTF----DALYKV 762
            |.|||.||||.|..:||...|..|:|:|||..|..::|.:|.:||...|.:||||    :||.||
  Rat   681 IFTLGGSPYPGIPVEELFSLLREGHRMERPPNCPSELYGLMRECWHAAPSQRPTFKQLVEALDKV 745

  Fly   763 -LSPKTTYVDINSLSDDYVFPPISEN 787
             |:....|:|:.     ..|.|.|.|
  Rat   746 LLAVSEEYLDLR-----LTFGPYSPN 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3277	NP_608762.3	STYKc	426..763	CDD:214568	123/347 (35%)
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	122/343 (36%)
Fgfr4	XP_006253668.1	IG	40..108	CDD:214652
		IGc2	47..104	CDD:197706
		Ig	153..237	CDD:299845	7/21 (33%)
		IG_like	158..237	CDD:214653	7/21 (33%)
		IG_like	252..346	CDD:214653	24/125 (19%)
		Ig3_FGFR-2	260..347	CDD:143266	22/118 (19%)
		PKc_like	453..766	CDD:304357	133/384 (35%)
		Pkinase_Tyr	466..742	CDD:285015	119/342 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810