DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3277 and Fgfr2

DIOPT Version :9

Sequence 1:	NP_608762.3	Gene:	CG3277 / 33543	FlyBaseID:	FBgn0031518	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_036844.1	Gene:	Fgfr2 / 25022	RGDID:	2611	Length:	841	Species:	Rattus norvegicus

Alignment Length:	857	Identity:	209/857 - (24%)
Similarity:	341/857 - (39%)	Gaps:	260/857 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 ILLLVLVRNAVGQAPRENATNPT--LISLVRSSEKEP-----EQMESHRYVTGLSEPIAMEPLTR 71
            :..:|.|.:|:.....|:.|:.:  .:|..||:::.|     |:||...:..    |.|.....|
  Rat   137 LYFMVNVTDAISSGDDEDDTDSSEDFVSENRSNQRAPYWTNTEKMEKRLHAV----PAANTVKFR 197

  Fly    72 MRLNPNPDGEITELTTNVTLYME-KIPRLQVRWQDNLPQGTSYNVLVSAVNNSRCPDAPC---SE 132
            .....||...:..|........| :|...:||.|       .:::::.:|..|...:..|   :|
  Rat   198 CPAGGNPTPTMRWLKNGKEFKQEHRIGGYKVRNQ-------HWSLIMESVVPSDKGNYTCLVENE 255

  Fly   133 YGIKEKNASAETHSVNLPVNPNLNVESVDCNYMFGCQYQVIVETSNAMVRRSARVYIPQCLEGKC 197
            ||       :..|:.:|.|                             |.||
  Rat   256 YG-------SINHTYHLDV-----------------------------VERS------------- 271

  Fly   198 SCQLAPTPPKVLAVAKMLSNETISINLSILASELLRK-EQDSHLHETLRTYKMQLKINEETNP-S 260
                   |.:.:..|.:.:|.:..:...:   |.:.| ..|:..|  ::..|...|...:..| .
  Rat   272 -------PHRPILQAGLPANASTVVGGDV---EFVCKVYSDAQPH--IQWIKHVEKNGSKYGPDG 324

  Fly   261 LPWGGVLKHL--------MTRVYKLSELNFRATPKGFEGVMKLG--LGTQLKEKASLSL----QA 311
            ||:..||||.        :..::.::|::      ..|.:.|:.  :| |..:.|.|::    ||
  Rat   325 LPYLKVLKHSGINSSNAEVLALFNVTEMD------AGEYICKVSNYIG-QANQSAWLTVLPKQQA 382

  Fly   312 VIIDPTGCEGPRSVTKVPVPANPVLLTEGDSVSNSIIVMSAMLIAIILAGLIMLLLRRRRARTTA 376
                        .|.:..:.|:|      |.:..:|..:...|||.::..:|..     |.:||.
  Rat   383 ------------PVREKEITASP------DYLEIAIYCIGVFLIACMVVTVIFC-----RMKTTT 424

  Fly   377 K------------------LRKQEQIYIQTFATSAIEMEDNVNYV------DKYVEKSQVLGLAD 417
            |                  ||:|    :...|.|:..|..|...|      ....:...:.|:::
  Rat   425 KKPDFSSQPAVHKLTKRIPLRRQ----VTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSE 485

  Fly   418 I-------FEVPHSAIQIGRMLGEGAFGQV--HEATAINLRRMRGTTIVAVKQLKPNPKADEVAE 473
            .       :|.|...:.:|:.||||.||||  .||..|:..|.:....||||.||.:....::::
  Rat   486 YELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDRPKEAVTVAVKMLKDDATEKDLSD 550

  Fly   474 YLAEIEMLKGVGTHHNVVSFLGCCTIKPPYLMIMEYVNKGNLLSYLRTVRKEASKLRNRNANYTS 538
            .::|:||:|.:|.|.|:::.||.||...|..:|:||.:||||..|||..|
  Rat   551 LVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARR--------------- 600

  Fly   539 CRPIMTRTNSTSSPKSQSVNYIELKASSQTIEMPQEDSTAHMNGIRQPHPSFAETTYTIVEDEDA 603
                         |.....:|       ....:|:|..|.
  Rat   601 -------------PPGMEYSY-------DINRVPEEQMTF------------------------- 620

  Fly   604 FEYILDNKELHNFALQIANGMRFLEEQEITHRDLAARNVLIDSNKTLKISDFGLSRH----GIYT 664
                   |:|.:...|:|.||.:|..|:..||||||||||:..|..:||:||||:|.    ..|.
  Rat   621 -------KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYK 678

  Fly   665 NTRTRKLPLRWLSIEAIRENVYSSKSDIWAYGVVLWEIGTLGASPYPTISNDELIPFLMAGNRLE 729
            .|...:||::|::.||:.:.||:.:||:|::||::|||.|||.||||.|..:||...|..|:|::
  Rat   679 KTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMD 743

  Fly   730 RPEICTPQVYTIMLQCWLEEPEERPTFDALYK------VLSPKTTYVDIN--------------- 773
            :|..||.::|.:|..||...|.:||||..|.:      .|:....|:|:.
  Rat   744 KPTNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLTQPLEQYSPSYPDTRS 808

  Fly   774 --SLSDDYVFPP 783
              |..||.||.|
  Rat   809 SCSSGDDSVFSP 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3277	NP_608762.3	STYKc	426..763	CDD:214568	116/348 (33%)
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	115/344 (33%)
Fgfr2	NP_036844.1	Ig	50..143	CDD:416386	1/5 (20%)
		Ig strand A	50..53	CDD:409353
		Ig strand A'	66..72	CDD:409353
		Ig strand B	75..85	CDD:409353
		Ig strand C	88..93	CDD:409353
		Ig strand C'	96..98	CDD:409353
		Ig strand D	103..107	CDD:409353
		Ig strand E	110..115	CDD:409353
		Ig strand F	121..130	CDD:409353
		Ig strand G	133..143	CDD:409353	1/5 (20%)
		IgI_2_FGFR	173..267	CDD:409443	23/111 (21%)
		Ig strand B	194..198	CDD:409443	0/3 (0%)
		Ig strand C	207..211	CDD:409443	0/3 (0%)
		Ig strand E	233..237	CDD:409443	0/3 (0%)
		Ig strand F	247..252	CDD:409443	1/4 (25%)
		Ig strand G	260..263	CDD:409443	1/2 (50%)
		Ig	275..377	CDD:416386	22/113 (19%)
		Ig strand A	275..278	CDD:409353	0/2 (0%)
		Ig strand A'	282..286	CDD:409353	1/3 (33%)
		Ig strand B	294..301	CDD:409353	2/6 (33%)
		Ig strand C	305..312	CDD:409353	1/8 (13%)
		Ig strand D	327..332	CDD:409353	1/4 (25%)
		Ig strand E	342..347	CDD:409353	0/4 (0%)
		Ig strand F	355..363	CDD:409353	2/7 (29%)
		Ig strand G	366..374	CDD:409353	3/8 (38%)
		FGFR3_TM	391..421	CDD:407957	9/40 (23%)
		PTKc_FGFR2	476..788	CDD:270679	120/378 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810