DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3277 and Pdgfrb

DIOPT Version :9

Sequence 1:	NP_608762.3	Gene:	CG3277 / 33543	FlyBaseID:	FBgn0031518	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_113713.1	Gene:	Pdgfrb / 24629	RGDID:	3285	Length:	1097	Species:	Rattus norvegicus

Alignment Length:	857	Identity:	227/857 - (26%)
Similarity:	354/857 - (41%)	Gaps:	226/857 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VPSRIVLILLLVL------------VRNAVGQAPRENATNPTLISLVRSSEKEPEQMESHRYVTG 59
            |||||..||.:..            |..:|.....|.|.|.|:|              .:.||.
  Rat   267 VPSRIGSILHIPTAELSDSGTYTCNVSVSVNDHGDEKAINVTVI--------------ENGYVR- 316

  Fly    60 LSEPIAMEPLTRMRLNPNPDGEITELTTNVTLYM--EKIPRLQVRW-QDNLPQGTS--------- 112
                 .:|.|        .|.:|.||..:.||.:  |..|...|.| :||...|.|
  Rat   317 -----LLETL--------EDVQIAELHRSRTLQVVFEAYPTPSVLWFKDNRTLGDSSAGELVLST 368

  Fly   113 YNV----LVSAVNNSRCPDAPCSEYGIKEKNASAETH-----SVNLPVNPNLNVESVDCNYMFGC 168
            .||    .||.:...|...:....|.::..:|..:..     .||:||.
  Rat   369 RNVSETRYVSELTLVRVKVSEAGYYTMRAFHADDQVQLSFKLQVNVPVR---------------- 417

  Fly   169 QYQVIVETSNAMVRRSARVY------IPQ-------CLEGK-CSCQLAPTPPKVLAVAKMLSNET 219
                ::|.|.:......::.      :||       |.:.| |..:|:|||         |.|.:
  Rat   418 ----VLELSESHPANGEQILRCRGRGMPQPNVTWSTCRDLKRCPRKLSPTP---------LGNSS 469

  Fly   220 ISINLSILASELLRKEQDSHLHETLRTYKMQLKINEETNPSLPWGGVLKHLMTRVYKLSELNFRA 284
                           :::|.|               |||                     :.|..
  Rat   470 ---------------KEESQL---------------ETN---------------------VTFWE 483

  Fly   285 TPKGFEGVMKLGLGTQLKEKASLSLQAVIIDPTGCEGPRSVTKVPVPANPVLLTEGDSVSNSIIV 349
            ..:.:|.|..|.|   ......||::.::.:..|.:. :.||.||           .|:...::|
  Rat   484 EDQEYEVVSTLRL---RHVDQPLSVRCMLQNSMGRDS-QEVTVVP-----------HSLPFKVVV 533

  Fly   350 MSAMLIAIIL---AGLIMLLLRRRRARTTAKLRKQEQIYIQTFATSAIEMEDNVNYVDKYVEKSQ 411
            :||:|..::|   :.:|:::|.:|:.|...:.:..|.:           ..|...|:  ||:..|
  Rat   534 ISAILALVVLTVISLIILIMLWQRKPRYEIRWKVIESV-----------SSDGHEYI--YVDPVQ 585

  Fly   412 VLGLADIFEVPHSAIQIGRMLGEGAFGQVHEATAINLRRMRGTTIVAVKQLKPNPKADEVAEYLA 476
             |.....:|:|...:.:||.||.||||||.||||..|...:.|..||||.||...::.|....::
  Rat   586 -LPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMS 649

  Fly   477 EIEMLKGVGTHHNVVSFLGCCTIKPPYLMIMEYVNKGNLLSYLRTVRKEASKLRNRNAN------ 535
            |::::..:|.|.|||:.||.||...|..:|.||...|:|:.||.. .|.....|:.|.:
  Rat   650 ELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHR-NKHTFLQRHSNKHCPPSTE 713

  Fly   536 -YTSCRPI----MTRTNSTSS--------PKSQSVNYIELKASSQTIEMPQEDSTAHMNGIRQPH 587
             |::..|:    .:..|.|..        .|.:||:|:.:......|:....:|:::|.......
  Rat   714 LYSNALPVGLSLPSHLNLTGESDGGYMDMSKDESVDYVPMLDMKGHIKYADIESSSYMAPYDNYV 778

  Fly   588 PSFAETTY--TIVEDEDAFEYILDNKELHNFALQIANGMRFLEEQEITHRDLAARNVLIDSNKTL 650
            ||..|.||  |::.|.....|    .:|..|:.|:||||.||..:...|||||||||||...|.:
  Rat   779 PSAPERTYRATLINDSPVLSY----TDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLV 839

  Fly   651 KISDFGLS----RHGIYTNTRTRKLPLRWLSIEAIRENVYSSKSDIWAYGVVLWEIGTLGASPYP 711
            ||.||||:    |...|.:..:..|||:|::.|:|..::|::.||:|::|::||||.|||.:|||
  Rat   840 KICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYP 904

  Fly   712 TI-SNDELIPFLMAGNRLERPEICTPQVYTIMLQCWLEEPEERPTFDALYKVL--------SPKT 767
            .: .||:....:..|.|:.:|...:.::|.||.:||.|:.|.||.|..|..:|        ..|.
  Rat   905 ELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQLVLLLERLLGEGYKKKY 969

  Fly   768 TYVDINSLSDDY 779
            ..||...|..|:
  Rat   970 QQVDEEFLRSDH 981

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3277	NP_608762.3	STYKc	426..763	CDD:214568	129/362 (36%)
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	128/358 (36%)
Pdgfrb	NP_113713.1	ig	36..113	CDD:395002
		Ig strand B	49..53	CDD:409353
		Ig strand C	59..62	CDD:409353
		Ig strand E	82..86	CDD:409353
		Ig strand F	96..101	CDD:409353
		Ig	211..309	CDD:416386	12/41 (29%)
		Ig strand A	211..215	CDD:409353
		Ig strand A'	222..226	CDD:409353
		Ig strand B	228..237	CDD:409353
		Ig strand C	242..247	CDD:409353
		Ig strand C'	250..252	CDD:409353
		Ig strand D	256..264	CDD:409353
		Ig strand E	270..277	CDD:409353	4/6 (67%)
		Ig strand F	287..293	CDD:409353	0/5 (0%)
		Ig strand G	298..304	CDD:409353	1/5 (20%)
		Ig	313..414	CDD:416386	26/114 (23%)
		PKc_like	561..952	CDD:419665	137/409 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1016..1097
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010